SGT2_SCHPO
ID SGT2_SCHPO Reviewed; 317 AA.
AC O13797;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Small glutamine-rich tetratricopeptide repeat-containing protein 2;
GN Name=sgt2; ORFNames=SPAC1142.02c, SPAC17G6.19c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Co-chaperone that binds to the molecular chaperone Hsp70 and
CC regulates Hsp70 ATPase activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the SGT family. {ECO:0000305}.
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DR EMBL; CU329670; CAB77009.1; -; Genomic_DNA.
DR PIR; T37851; T37851.
DR RefSeq; XP_001713087.1; XM_001713035.2.
DR AlphaFoldDB; O13797; -.
DR SMR; O13797; -.
DR BioGRID; 278865; 18.
DR STRING; 4896.SPAC1142.02c.1; -.
DR iPTMnet; O13797; -.
DR MaxQB; O13797; -.
DR PaxDb; O13797; -.
DR PRIDE; O13797; -.
DR EnsemblFungi; SPAC1142.02c.1; SPAC1142.02c.1:pep; SPAC1142.02c.
DR PomBase; SPAC1142.02c; -.
DR VEuPathDB; FungiDB:SPAC1142.02c; -.
DR eggNOG; KOG0553; Eukaryota.
DR HOGENOM; CLU_044224_1_1_1; -.
DR InParanoid; O13797; -.
DR OMA; FLHDQLH; -.
DR PhylomeDB; O13797; -.
DR Reactome; R-SPO-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR PRO; PR:O13797; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0072380; C:TRC complex; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0006620; P:post-translational protein targeting to endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; ISO:PomBase.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR032374; SGTA_dimer.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF16546; SGTA_dimer; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nucleus; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..317
FT /note="Small glutamine-rich tetratricopeptide repeat-
FT containing protein 2"
FT /id="PRO_0000363377"
FT REPEAT 14..48
FT /note="TPR 1"
FT REPEAT 83..116
FT /note="TPR 2"
FT REPEAT 118..150
FT /note="TPR 3"
FT REPEAT 151..184
FT /note="TPR 4"
FT REGION 198..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 317 AA; 34002 MW; 7C4C147666BCD31F CRC64;
MSSNKVTAAI IDYLKQAITT GSISEEEKES LEVAAQCIQD SFKIKPEEIK PKSGDRLVAA
FEEYEKLHPV EEDSTAHVNK EEAEKLKLEG NNAIAAKDYQ KALDLYTKAI EIDPTSPVYY
SNRAAAYNQL GQFENAVEDA LTCLSLDPHH ARAFGRLGRA KLSLGDAAAA ADAYKKGLDF
DPNNEVLKRG LEAANKQLNQ PSDSSATSGA DQARTSAGAA PDLGSIFGGG MPDLGSLMNN
PAVMNMARNL MQSGALNNIM NDPNIANMAR NFQSGGGMPD LSSLANNPQL QNLARNFMNN
NNNGNTDNNN QGNPPPQ
