SGTB_MOUSE
ID SGTB_MOUSE Reviewed; 304 AA.
AC Q8VD33;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Small glutamine-rich tetratricopeptide repeat-containing protein beta;
DE AltName: Full=Beta-SGT;
GN Name=Sgtb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Co-chaperone that binds directly to HSC70 and HSP70 and
CC regulates their ATPase activity. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomerize. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SGT family. {ECO:0000305}.
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DR EMBL; AK049820; BAC33934.1; -; mRNA.
DR EMBL; AK082080; BAC38406.1; -; mRNA.
DR EMBL; BC017611; AAH17611.1; -; mRNA.
DR CCDS; CCDS26746.1; -.
DR RefSeq; NP_659087.1; NM_144838.1.
DR RefSeq; XP_006517673.1; XM_006517610.2.
DR AlphaFoldDB; Q8VD33; -.
DR SMR; Q8VD33; -.
DR BioGRID; 230046; 4.
DR STRING; 10090.ENSMUSP00000041307; -.
DR iPTMnet; Q8VD33; -.
DR PhosphoSitePlus; Q8VD33; -.
DR MaxQB; Q8VD33; -.
DR PaxDb; Q8VD33; -.
DR PeptideAtlas; Q8VD33; -.
DR PRIDE; Q8VD33; -.
DR ProteomicsDB; 261207; -.
DR Antibodypedia; 23800; 115 antibodies from 20 providers.
DR Ensembl; ENSMUST00000044385; ENSMUSP00000041307; ENSMUSG00000042743.
DR GeneID; 218544; -.
DR KEGG; mmu:218544; -.
DR UCSC; uc007rss.1; mouse.
DR CTD; 54557; -.
DR MGI; MGI:2444615; Sgtb.
DR VEuPathDB; HostDB:ENSMUSG00000042743; -.
DR eggNOG; KOG0553; Eukaryota.
DR GeneTree; ENSGT00940000158321; -.
DR HOGENOM; CLU_044224_0_0_1; -.
DR InParanoid; Q8VD33; -.
DR OMA; ASGQHEK; -.
DR OrthoDB; 687493at2759; -.
DR PhylomeDB; Q8VD33; -.
DR TreeFam; TF313092; -.
DR BioGRID-ORCS; 218544; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8VD33; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8VD33; protein.
DR Bgee; ENSMUSG00000042743; Expressed in substantia nigra and 216 other tissues.
DR ExpressionAtlas; Q8VD33; baseline and differential.
DR Genevisible; Q8VD33; MM.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0072380; C:TRC complex; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0006620; P:post-translational protein targeting to endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR032374; SGTA_dimer.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF16546; SGTA_dimer; 1.
DR Pfam; PF00515; TPR_1; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Acetylation; Chaperone; Phosphoprotein; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..304
FT /note="Small glutamine-rich tetratricopeptide repeat-
FT containing protein beta"
FT /id="PRO_0000106369"
FT REPEAT 15..49
FT /note="TPR 1"
FT REPEAT 85..118
FT /note="TPR 2"
FT REPEAT 120..152
FT /note="TPR 3"
FT REPEAT 153..186
FT /note="TPR 4"
FT MOD_RES 131
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O43765"
FT MOD_RES 293
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O43765"
FT MOD_RES 295
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96EQ0"
FT MOD_RES 297
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96EQ0"
SQ SEQUENCE 304 AA; 33429 MW; 78466943255ADB9A CRC64;
MSSVKPLVYA VIRFLREQSQ MDAYTSDEQE SLEVAIQCLE TVFKISPEDT HLAVSQPLTE
MFTNSVCKND IRPLSNSVPE DVGKADQLKD EGNNHMKEEN YAAAVDCYTQ AIELDPNNAV
YYCNRAAAQS KLSHYTDAIK DCEKAIAIDS KYSKAYGRMG LALTAMNKFE EAVTSYQKAL
DLDPENDSYK SNLKIAEQKL REVSSPTGTG LSFDMASLIN NPAFITMAAS LMQNPQVQQL
MSGMMTNAIG GPAAGVGGLT DLSSLIQAGQ QFAQQIQQQN PELIEQLRNH IRSRSFSSSA
DEHS
