ID   SGT_DICDI               Reviewed;         334 AA.
AC   Q54VG4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Small glutamine-rich tetratricopeptide repeat-containing protein;
GN   Name=sgt; Synonyms=sgtA; ORFNames=DDB_G0280345;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=AX2;
RX   PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA   Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA   Soldati T.;
RT   "Proteomics fingerprinting of phagosome maturation and evidence for the
RT   role of a Galpha during uptake.";
RL   Mol. Cell. Proteomics 5:2228-2243(2006).
CC   -!- FUNCTION: May act as a co-chaperone and regulate the ATPase activity of
CC       heat shock proteins.
CC   -!- SIMILARITY: Belongs to the SGT family. {ECO:0000305}.
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DR   EMBL; AAFI02000035; EAL67399.1; -; Genomic_DNA.
DR   RefSeq; XP_641391.1; XM_636299.1.
DR   AlphaFoldDB; Q54VG4; -.
DR   SMR; Q54VG4; -.
DR   STRING; 44689.DDB0238179; -.
DR   PaxDb; Q54VG4; -.
DR   EnsemblProtists; EAL67399; EAL67399; DDB_G0280345.
DR   GeneID; 8622525; -.
DR   KEGG; ddi:DDB_G0280345; -.
DR   dictyBase; DDB_G0280345; sgtA.
DR   eggNOG; KOG0553; Eukaryota.
DR   HOGENOM; CLU_044224_1_1_1; -.
DR   InParanoid; Q54VG4; -.
DR   OMA; ASGQHEK; -.
DR   PhylomeDB; Q54VG4; -.
DR   Reactome; R-DDI-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR   PRO; PR:Q54VG4; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR   GO; GO:0072380; C:TRC complex; IBA:GO_Central.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0006620; P:post-translational protein targeting to endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR032374; SGTA_dimer.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF16546; SGTA_dimer; 1.
DR   Pfam; PF00515; TPR_1; 2.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..334
FT                   /note="Small glutamine-rich tetratricopeptide repeat-
FT                   containing protein"
FT                   /id="PRO_0000333274"
FT   REPEAT          145..178
FT                   /note="TPR 1"
FT   REPEAT          180..212
FT                   /note="TPR 2"
FT   REPEAT          213..246
FT                   /note="TPR 3"
SQ   SEQUENCE   334 AA;  36711 MW;  DFD66FD34B59DF3E CRC64;
     MASNKQKLAV SILNFLKVSM KEDAENAESL QVAVECIRDV FGVDENDSTL QVSAPLSEIF
     DKFIGENNTN TTTTTTTTTT KLSKEELLNQ TYSEIPYELL ESFKQFITIL EQKGAFANED
     SCETVIKATK QKFMESKAGE VKAIAEKLKN EGNAKLNEGK HQEALSCYNK AILYDNTNAI
     YFANRAATYS ALQNFEKSIE DCLEAIKRNP NYGKAYTRMG SAYTSLGKFS EAMEAYNKAI
     ELEPNNETFK ASLANAERLA AAANNQAPAM PNIPGMPDLG GLDFGSLLSN PAIRGLANNL
     MSDPKMKEMM DNGDMASLLN NPDLLKMFGN LGKK