SH21A_MACMU
ID SH21A_MACMU Reviewed; 128 AA.
AC Q71S10;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=SH2 domain-containing protein 1A;
GN Name=SH2D1A;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Peripheral blood lymphocyte;
RX PubMed=11477068; DOI=10.1074/jbc.m101305200;
RA Morra M., Simarro-Grande M., Martin M., Chen A.S.-I., Lanyi A.,
RA Silander O., Calpe S., Davis J., Pawson T., Eck M.J., Sumegi J., Engel P.,
RA Li S.-C., Terhorst C.;
RT "Characterization of SH2D1A missense mutations identified in X-linked
RT lymphoproliferative disease patients.";
RL J. Biol. Chem. 276:36809-36816(2001).
CC -!- FUNCTION: Cytoplasmic adapter regulating receptors of the signaling
CC lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244,
CC LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with
CC SH2D1B/EAT-2. Initially it has been proposed that association with
CC SLAMF1 prevents SLAMF1 binding to inhibitory effectors including
CC INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions,
CC recruits FYN which subsequently phosphorylates and activates SLAMF1.
CC Positively regulates CD244/2B4- and CD84-mediated natural killer (NK)
CC cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-
CC mediated NK cell activation. In the context of NK cell-mediated
CC cytotoxicity enhances conjugate formation with target cells (By
CC similarity). May also regulate the activity of the neurotrophin
CC receptors NTRK1, NTRK2 and NTRK3 (By similarity).
CC {ECO:0000250|UniProtKB:B2RZ59, ECO:0000250|UniProtKB:O60880,
CC ECO:0000250|UniProtKB:O88890}.
CC -!- SUBUNIT: Interacts with CD84, CD244, LY9, SLAMF1 and FYN. Interacts
CC with NTRK1, NTRK2 and NTRK3 (By similarity).
CC {ECO:0000250|UniProtKB:B2RZ59, ECO:0000250|UniProtKB:O60880}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O60880}.
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DR EMBL; AF322912; AAK11578.1; -; mRNA.
DR RefSeq; NP_001028009.1; NM_001032837.1.
DR AlphaFoldDB; Q71S10; -.
DR SMR; Q71S10; -.
DR STRING; 9544.ENSMMUP00000009961; -.
DR Ensembl; ENSMMUT00000103918; ENSMMUP00000071775; ENSMMUG00000007585.
DR GeneID; 574156; -.
DR KEGG; mcc:574156; -.
DR CTD; 4068; -.
DR VEuPathDB; HostDB:ENSMMUG00000007585; -.
DR VGNC; VGNC:97828; SH2D1A.
DR eggNOG; KOG0565; Eukaryota.
DR GeneTree; ENSGT00940000155920; -.
DR HOGENOM; CLU_125532_1_0_1; -.
DR InParanoid; Q71S10; -.
DR OMA; CVLCNGY; -.
DR OrthoDB; 1417830at2759; -.
DR TreeFam; TF343096; -.
DR Proteomes; UP000006718; Chromosome X.
DR Bgee; ENSMMUG00000007585; Expressed in spleen and 11 other tissues.
DR ExpressionAtlas; Q71S10; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0007267; P:cell-cell signaling; IEA:InterPro.
DR GO; GO:0006968; P:cellular defense response; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IBA:GO_Central.
DR GO; GO:0050776; P:regulation of immune response; IBA:GO_Central.
DR GO; GO:0009966; P:regulation of signal transduction; IBA:GO_Central.
DR CDD; cd10400; SH2_SAP1a; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR017289; SH2_prot_1A.
DR InterPro; IPR035876; SH2D1A_SH2.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF037828; SH2_p1A; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Adaptive immunity; Cytoplasm; Immunity; Innate immunity;
KW Reference proteome; SH2 domain.
FT CHAIN 1..128
FT /note="SH2 domain-containing protein 1A"
FT /id="PRO_0000356883"
FT DOMAIN 6..102
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 67..92
FT /note="Interaction with FYN SH3 domain"
FT /evidence="ECO:0000250|UniProtKB:O88890"
FT REGION 106..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 89
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O60880"
SQ SEQUENCE 128 AA; 14187 MW; 90234E7A6614EE3D CRC64;
MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE
TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED
PDVCLKAP
