ID   SH24A_XENTR             Reviewed;         453 AA.
AC   Q08CX2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=SH2 domain-containing protein 4A;
GN   Name=sh2d4a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits estrogen-induced cell proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; BC124048; AAI24049.1; -; mRNA.
DR   RefSeq; NP_001072704.1; NM_001079236.2.
DR   RefSeq; XP_012821264.1; XM_012965810.2.
DR   RefSeq; XP_012821265.1; XM_012965811.2.
DR   RefSeq; XP_012821266.1; XM_012965812.2.
DR   AlphaFoldDB; Q08CX2; -.
DR   SMR; Q08CX2; -.
DR   PaxDb; Q08CX2; -.
DR   PRIDE; Q08CX2; -.
DR   DNASU; 780161; -.
DR   Ensembl; ENSXETT00000009693; ENSXETP00000009693; ENSXETG00000004464.
DR   GeneID; 780161; -.
DR   KEGG; xtr:780161; -.
DR   CTD; 63898; -.
DR   Xenbase; XB-GENE-492416; sh2d4a.
DR   eggNOG; ENOG502QVV5; Eukaryota.
DR   HOGENOM; CLU_029296_1_0_1; -.
DR   InParanoid; Q08CX2; -.
DR   OMA; YPCGQQG; -.
DR   OrthoDB; 782492at2759; -.
DR   TreeFam; TF336893; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004464; Expressed in ovary and 14 other tissues.
DR   ExpressionAtlas; Q08CX2; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0019902; F:phosphatase binding; ISS:UniProtKB.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome; SH2 domain.
FT   CHAIN           1..453
FT                   /note="SH2 domain-containing protein 4A"
FT                   /id="PRO_0000308602"
FT   DOMAIN          347..439
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          280..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          96..127
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  53004 MW;  285CF6E74F3D2347 CRC64;
     MLKQILADMY IDPELLAELS EEQKQILFFK MRQEQIRRWQ EWEAKCDQNE DKKRNSRPRK
     ACNKSVHWRF GTDQEVWVWV MGEHSSDKPY DQICDEIIAE QARREAEKEA EQLRKKQEVE
     LSQLSTLRLH PHNNADLLKK NTDTKQMVNE NVRIANQQII NDENQSIIEK PRTVEDILSA
     ATSKNKYEVK QKKENILKEK ENDRLQERTQ EIYMNWKEAQ EVKQKLEKED KEWQESLRKS
     KLADERRRSV AKQARDDYKR LSMQGINRGK VADTAKTFGA VKRPPIPPKP KLPPSANNSS
     INRMDRRQGI RRLNSAINRE NIIKWFKEEQ LPLKAGWDKS GSYVEPWFHG IISRQESEQL
     LGSHGHGSFL LRVSEKIQGY VLSYCSEEGC AHFLIDASAT SYSFLGVDQL QHTTLADLVE
     YHKTEPIPSL GRELLRFPCG QKKGVCDYSD LLE