SH24B_MOUSE
ID SH24B_MOUSE Reviewed; 431 AA.
AC A6X942; B2RSQ7; Q8BQI0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=SH2 domain-containing protein 4B;
GN Name=Sh2d4b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6X942-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6X942-2; Sequence=VSP_029013;
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DR EMBL; AK050671; BAC34372.1; -; mRNA.
DR EMBL; AK134033; BAE21988.1; -; mRNA.
DR EMBL; CT025537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC138964; AAI38965.1; -; mRNA.
DR CCDS; CCDS26955.1; -. [A6X942-1]
DR RefSeq; NP_808484.2; NM_177816.3. [A6X942-1]
DR RefSeq; XP_017171549.1; XM_017316060.1. [A6X942-2]
DR AlphaFoldDB; A6X942; -.
DR SMR; A6X942; -.
DR BioGRID; 236593; 1.
DR STRING; 10090.ENSMUSP00000093699; -.
DR PhosphoSitePlus; A6X942; -.
DR PaxDb; A6X942; -.
DR PRIDE; A6X942; -.
DR ProteomicsDB; 257130; -. [A6X942-1]
DR ProteomicsDB; 257131; -. [A6X942-2]
DR Antibodypedia; 48780; 67 antibodies from 16 providers.
DR Ensembl; ENSMUST00000070328; ENSMUSP00000064708; ENSMUSG00000037833. [A6X942-2]
DR Ensembl; ENSMUST00000096000; ENSMUSP00000093699; ENSMUSG00000037833. [A6X942-1]
DR GeneID; 328381; -.
DR KEGG; mmu:328381; -.
DR UCSC; uc007tcd.1; mouse. [A6X942-2]
DR UCSC; uc007tce.1; mouse. [A6X942-1]
DR CTD; 387694; -.
DR MGI; MGI:1925182; Sh2d4b.
DR VEuPathDB; HostDB:ENSMUSG00000037833; -.
DR eggNOG; ENOG502QVV5; Eukaryota.
DR GeneTree; ENSGT00940000159732; -.
DR HOGENOM; CLU_1556950_0_0_1; -.
DR InParanoid; A6X942; -.
DR OMA; QSGFKHF; -.
DR OrthoDB; 782492at2759; -.
DR PhylomeDB; A6X942; -.
DR TreeFam; TF336893; -.
DR BioGRID-ORCS; 328381; 1 hit in 71 CRISPR screens.
DR PRO; PR:A6X942; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; A6X942; protein.
DR Bgee; ENSMUSG00000037833; Expressed in animal zygote and 51 other tissues.
DR Genevisible; A6X942; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR CDD; cd10351; SH2_SH2D4B; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035839; SH2D4B_SH2.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; SH2 domain.
FT CHAIN 1..431
FT /note="SH2 domain-containing protein 4B"
FT /id="PRO_0000308601"
FT DOMAIN 325..417
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 201..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..253
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029013"
SQ SEQUENCE 431 AA; 51120 MW; 091871DEC7A439EA CRC64;
MLQQILQDMY IDPELLAELS DVQKHILFYK MREEQLRRWR EREAWDALAQ AEGLRPAKVK
RASNKHLQWL LGADGEVWVW VMGEGPGDKP YEEISEELIA ERARLQAQKE AEELWRQKEA
EITKKFRDAL ANEKARILAE KWKVEMEDRK AAKILEERIH EEFKRKEEEE RRRGEEQIRL
QEEQRAKELY WTLKQAQLHS QASENEEREW EEQLRRSKAA DEERSRRAQR ARDEYRRHSL
RAIQKGTVAG LSTMFQELGQ NHEQEARLYH QLPDTSPPSP LTGPDRTWER PLRPLSREVI
VRWFKEEQLP RRAGFERNTK SIAPWFHGII SRESAEDLLE NMTEGAFLVR VSEKIWGYTL
SYRLQRGFKH FLVDASGDFY SFLGVDPNRH ATLTDLIDFH KEEIITVSGG ELLQEPCGQR
DSPPDYHLLF E
