SH2D5_HUMAN
ID SH2D5_HUMAN Reviewed; 423 AA.
AC Q6ZV89; B7Z3W3; Q5SSJ2;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=SH2 domain-containing protein 5 {ECO:0000312|HGNC:HGNC:28819};
GN Name=SH2D5 {ECO:0000312|HGNC:HGNC:28819};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hippocampus, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [5]
RP INTERACTION WITH BCR.
RX PubMed=25331951; DOI=10.1074/jbc.m114.615112;
RA Gray E.J., Petsalaki E., James D.A., Bagshaw R.D., Stacey M.M., Rocks O.,
RA Gingras A.C., Pawson T.;
RT "src homology 2 domain containing protein 5 (sh2d5) binds the breakpoint
RT cluster region protein, BCR, and regulates levels of Rac1-GTP.";
RL J. Biol. Chem. 289:35397-35408(2014).
CC -!- FUNCTION: May be involved in synaptic plasticity regulation through the
CC control of Rac-GTP levels. {ECO:0000250|UniProtKB:Q8JZW5}.
CC -!- SUBUNIT: Interacts with BCR. {ECO:0000269|PubMed:25331951}.
CC -!- INTERACTION:
CC Q6ZV89-1; P11274: BCR; NbExp=2; IntAct=EBI-15101685, EBI-712838;
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000250|UniProtKB:Q8JZW5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZV89-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZV89-2; Sequence=VSP_045938;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC85974.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK124869; BAC85974.1; ALT_INIT; mRNA.
DR EMBL; AK296431; BAH12349.1; -; mRNA.
DR EMBL; AL663074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471134; EAW94947.1; -; Genomic_DNA.
DR CCDS; CCDS41280.1; -. [Q6ZV89-2]
DR CCDS; CCDS44080.1; -. [Q6ZV89-1]
DR RefSeq; NP_001096630.1; NM_001103160.1. [Q6ZV89-2]
DR RefSeq; NP_001096631.1; NM_001103161.1. [Q6ZV89-1]
DR RefSeq; XP_011539761.1; XM_011541459.1. [Q6ZV89-1]
DR RefSeq; XP_011539762.1; XM_011541460.1. [Q6ZV89-1]
DR RefSeq; XP_011539763.1; XM_011541461.2. [Q6ZV89-1]
DR AlphaFoldDB; Q6ZV89; -.
DR SMR; Q6ZV89; -.
DR BioGRID; 134738; 8.
DR IntAct; Q6ZV89; 5.
DR MINT; Q6ZV89; -.
DR STRING; 9606.ENSP00000406026; -.
DR iPTMnet; Q6ZV89; -.
DR PhosphoSitePlus; Q6ZV89; -.
DR BioMuta; SH2D5; -.
DR DMDM; 363548475; -.
DR EPD; Q6ZV89; -.
DR jPOST; Q6ZV89; -.
DR MassIVE; Q6ZV89; -.
DR PaxDb; Q6ZV89; -.
DR PeptideAtlas; Q6ZV89; -.
DR PRIDE; Q6ZV89; -.
DR ProteomicsDB; 68401; -. [Q6ZV89-1]
DR Antibodypedia; 48002; 97 antibodies from 25 providers.
DR DNASU; 400745; -.
DR Ensembl; ENST00000375031.5; ENSP00000364171.1; ENSG00000189410.12. [Q6ZV89-2]
DR Ensembl; ENST00000444387.7; ENSP00000406026.2; ENSG00000189410.12. [Q6ZV89-1]
DR GeneID; 400745; -.
DR KEGG; hsa:400745; -.
DR MANE-Select; ENST00000444387.7; ENSP00000406026.2; NM_001103161.2; NP_001096631.1.
DR UCSC; uc001bdt.1; human. [Q6ZV89-1]
DR CTD; 400745; -.
DR DisGeNET; 400745; -.
DR GeneCards; SH2D5; -.
DR HGNC; HGNC:28819; SH2D5.
DR HPA; ENSG00000189410; Group enriched (brain, testis).
DR neXtProt; NX_Q6ZV89; -.
DR OpenTargets; ENSG00000189410; -.
DR PharmGKB; PA142670927; -.
DR VEuPathDB; HostDB:ENSG00000189410; -.
DR eggNOG; ENOG502RXFM; Eukaryota.
DR GeneTree; ENSGT00510000048936; -.
DR HOGENOM; CLU_053535_0_0_1; -.
DR InParanoid; Q6ZV89; -.
DR OMA; TSGQWCL; -.
DR OrthoDB; 791930at2759; -.
DR PhylomeDB; Q6ZV89; -.
DR TreeFam; TF334487; -.
DR PathwayCommons; Q6ZV89; -.
DR SignaLink; Q6ZV89; -.
DR BioGRID-ORCS; 400745; 12 hits in 1068 CRISPR screens.
DR GenomeRNAi; 400745; -.
DR Pharos; Q6ZV89; Tdark.
DR PRO; PR:Q6ZV89; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6ZV89; protein.
DR Bgee; ENSG00000189410; Expressed in nucleus accumbens and 106 other tissues.
DR ExpressionAtlas; Q6ZV89; baseline and differential.
DR Genevisible; Q6ZV89; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; SH2 domain; Synapse.
FT CHAIN 1..423
FT /note="SH2 domain-containing protein 5"
FT /id="PRO_0000231581"
FT DOMAIN 296..392
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 392..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..84
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_045938"
SQ SEQUENCE 423 AA; 46797 MW; BD0C7D55C7FF8FDB CRC64;
MQKAGAGGRR ASDCGLAPHR PRCITKFAQY VGSFPVDDLD TQESVWLVQQ QLWALKDCPR
RRAVILKFSL QGLKIYSGEG EVLLMAHALR RILYSTWCPA DCQFAFMARN PRSPASKLFC
HLFVGSQPGE VQILHLLLCR SFQLAYLLQH PEERAQPEPC PGPTGEVPLK PLSSSGGLVR
EPFGRDQLSQ NVHALVSFRR LPAEGLVGSG KELPESEGRA RHARLGNPYC SPTLVRKKAI
RSKVIRSGAY RGCTYETQLQ LSAREAFPAA WEAWPRGPGG HSCLVESEGS LTENIWAFAG
ISRPCALALL RRDVLGAFLL WPELGASGQW CLSVRTQCGV VPHQVFRNHL GRYCLEHLPA
EFPSLEALVE NHAVTERSLF CPLDMGRLNP TYEEQDCGPP GRPPRTLRPL SHAKSEAELQ
GLG
