ID   SH2D5_MOUSE             Reviewed;         429 AA.
AC   Q8JZW5;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2017, sequence version 3.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=SH2 domain-containing protein 5 {ECO:0000250|UniProtKB:Q6ZV89};
GN   Name=Sh2d5 {ECO:0000312|MGI:MGI:2446215};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3]
RP   FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH BCR, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=25331951; DOI=10.1074/jbc.m114.615112;
RA   Gray E.J., Petsalaki E., James D.A., Bagshaw R.D., Stacey M.M., Rocks O.,
RA   Gingras A.C., Pawson T.;
RT   "src homology 2 domain containing protein 5 (sh2d5) binds the breakpoint
RT   cluster region protein, BCR, and regulates levels of Rac1-GTP.";
RL   J. Biol. Chem. 289:35397-35408(2014).
CC   -!- FUNCTION: May be involved in synaptic plasticity regulation through the
CC       control of Rac-GTP levels. {ECO:0000303|PubMed:25331951}.
CC   -!- SUBUNIT: Interacts with BCR. {ECO:0000269|PubMed:25331951}.
CC   -!- INTERACTION:
CC       Q8JZW5; P11274: BCR; Xeno; NbExp=2; IntAct=EBI-15101675, EBI-712838;
CC   -!- SUBCELLULAR LOCATION: Postsynaptic density
CC       {ECO:0000269|PubMed:25331951}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in brain, particularly in
CC       Purkinjie cells in the cerebellum and the cornu ammonis of the
CC       hippocampus. {ECO:0000269|PubMed:25331951}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH36961.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC036961; AAH36961.1; ALT_INIT; mRNA.
DR   CCDS; CCDS51335.1; -.
DR   RefSeq; NP_001093101.1; NM_001099631.1.
DR   AlphaFoldDB; Q8JZW5; -.
DR   SMR; Q8JZW5; -.
DR   IntAct; Q8JZW5; 2.
DR   STRING; 10090.ENSMUSP00000101450; -.
DR   iPTMnet; Q8JZW5; -.
DR   PhosphoSitePlus; Q8JZW5; -.
DR   EPD; Q8JZW5; -.
DR   PaxDb; Q8JZW5; -.
DR   PRIDE; Q8JZW5; -.
DR   ProteomicsDB; 255401; -.
DR   Antibodypedia; 48002; 97 antibodies from 25 providers.
DR   Ensembl; ENSMUST00000105823; ENSMUSP00000101449; ENSMUSG00000045349.
DR   Ensembl; ENSMUST00000105824; ENSMUSP00000101450; ENSMUSG00000045349.
DR   GeneID; 230863; -.
DR   KEGG; mmu:230863; -.
DR   CTD; 400745; -.
DR   MGI; MGI:2446215; Sh2d5.
DR   VEuPathDB; HostDB:ENSMUSG00000045349; -.
DR   eggNOG; ENOG502RXFM; Eukaryota.
DR   GeneTree; ENSGT00510000048936; -.
DR   InParanoid; Q8JZW5; -.
DR   OMA; TSGQWCL; -.
DR   OrthoDB; 791930at2759; -.
DR   PRO; PR:Q8JZW5; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q8JZW5; protein.
DR   Bgee; ENSMUSG00000045349; Expressed in caudate-putamen and 185 other tissues.
DR   ExpressionAtlas; Q8JZW5; baseline and differential.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0014069; C:postsynaptic density; IDA:UniProtKB.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS01179; PID; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; SH2 domain; Synapse.
FT   CHAIN           1..429
FT                   /note="SH2 domain-containing protein 5"
FT                   /id="PRO_0000231582"
FT   DOMAIN          302..398
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
SQ   SEQUENCE   429 AA;  47380 MW;  571742B89AC1E558 CRC64;
     MQRAGAGARR ASDCGPAPYR PRCIAKLAQY VGSFPVDDLD TQESVGLVQQ QLWALQDCSR
     RRAVILKFSL QGLKIYSGEG EVLLMAHALK RILYATWYPA ACQFAFIARN PRSPSSKLFC
     HLFVGSQPGE VHILYLLLCR SFQLAYLLQH PEERAQSEPC LAPVGDLSLK PLCSPGVPPA
     LVREPFSRDQ LSQNVHALVS FRRLPAEGLL GSNGKELPES EGRGGTRHIR LGNPYCSPTL
     VRKKAIRSKV IRSGAYRGCT YETQLQLSAR EAFPAAWEAW PRGPGGPSCL VENEGSLTEN
     IWAFAGLSRS CALSLLRRDV HGAFLLWPEP GTSDQWSLSV RTQCGVVPHQ VFRNHLGRFC
     LEHLPAEFPS LEALVESHAG VERSLFCPLS MGRLNPTYEE QDCGTEGRFP RTLRPLSHAK
     SEAELQGLG