ID   SH2D5_PONAB             Reviewed;         423 AA.
AC   Q5R732; A0A0A0MXM4;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2017, sequence version 3.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=SH2 domain-containing protein 5 {ECO:0000250|UniProtKB:Q6ZV89};
GN   Name=SH2D5 {ECO:0000250|UniProtKB:Q6ZV89};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wilson R.K., Mardis E.;
RT   "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-423.
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in synaptic plasticity regulation through the
CC       control of Rac-GTP levels. {ECO:0000250|UniProtKB:Q8JZW5}.
CC   -!- SUBUNIT: Interacts with BCR (By similarity).
CC       {ECO:0000250|UniProtKB:Q6ZV89}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic density
CC       {ECO:0000250|UniProtKB:Q8JZW5}.
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DR   EMBL; ABGA01080291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABGA01080292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR860288; CAH92428.1; -; mRNA.
DR   AlphaFoldDB; Q5R732; -.
DR   SMR; Q5R732; -.
DR   STRING; 9601.ENSPPYP00000002047; -.
DR   eggNOG; ENOG502RXFM; Eukaryota.
DR   HOGENOM; CLU_053535_0_0_1; -.
DR   InParanoid; Q5R732; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; SH2 domain; Synapse.
FT   CHAIN           1..423
FT                   /note="SH2 domain-containing protein 5"
FT                   /id="PRO_0000231583"
FT   DOMAIN          296..392
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          394..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  46225 MW;  6C8E4351CA042C0D CRC64;
     MQKAGAGGRR ASDCGLAPHR PRCITKFAQY VGLLPCGRPG HPGERVAGAA AAVGAEDCPR
     RRAVILKFSL QGLKIYSGEG EVLLMAHALR RILYSTWCPA DCQFAFVARN PRSPASKFFC
     HLFVGSQPGE VQILHLLLCR SFQLAYLLQH PEERAQPEPC PGPTGEVPLK PLSSSGGLVR
     EPFGRDQLSQ NVHALVSFRR LPAEGLVGSG KELPESEGRA RHARLGNPYC SPTLVRKKAI
     RSKVIRSGAY RGCTYETQLQ LSAREAFPAA WEAWPRGPGG HSCLVESEGS LTENIWAFAG
     ISRPCALALL RRDVLGAFLL WPELGASGQW CLSVRTQCGV VPHQVFRNHL GRYCLEHLPA
     EFPSLEALVE NHAVTERSLF CPLDMGRLNP TYEEQDCGPL GRPPRTLRPL SHAKSEAELQ
     GLG