SH2D6_HUMAN
ID SH2D6_HUMAN Reviewed; 175 AA.
AC Q7Z4S9; A6ND14; Q6R306;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=SH2 domain-containing protein 6;
GN Name=SH2D6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RA Zan Q., Guo J.H., Yu L.;
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Z4S9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z4S9-2; Sequence=VSP_029014, VSP_029015;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF450483; AAP97677.1; -; mRNA.
DR EMBL; AY517502; AAR98781.1; -; mRNA.
DR EMBL; AC062037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016859347.1; XM_017003858.1. [Q7Z4S9-2]
DR AlphaFoldDB; Q7Z4S9; -.
DR SMR; Q7Z4S9; -.
DR STRING; 9606.ENSP00000341867; -.
DR BioMuta; SH2D6; -.
DR DMDM; 74723338; -.
DR PaxDb; Q7Z4S9; -.
DR PeptideAtlas; Q7Z4S9; -.
DR PRIDE; Q7Z4S9; -.
DR ProteomicsDB; 69230; -. [Q7Z4S9-1]
DR ProteomicsDB; 69231; -. [Q7Z4S9-2]
DR DNASU; 284948; -.
DR Ensembl; ENST00000389938.7; ENSP00000374588.3; ENSG00000152292.18.
DR GeneID; 284948; -.
DR UCSC; uc002spq.3; human. [Q7Z4S9-1]
DR CTD; 284948; -.
DR DisGeNET; 284948; -.
DR GeneCards; SH2D6; -.
DR HGNC; HGNC:30439; SH2D6.
DR neXtProt; NX_Q7Z4S9; -.
DR PharmGKB; PA162403243; -.
DR VEuPathDB; HostDB:ENSG00000152292; -.
DR eggNOG; ENOG502SCFD; Eukaryota.
DR HOGENOM; CLU_133893_0_0_1; -.
DR InParanoid; Q7Z4S9; -.
DR OrthoDB; 1452299at2759; -.
DR PhylomeDB; Q7Z4S9; -.
DR TreeFam; TF343096; -.
DR PathwayCommons; Q7Z4S9; -.
DR SignaLink; Q7Z4S9; -.
DR BioGRID-ORCS; 284948; 10 hits in 1060 CRISPR screens.
DR GenomeRNAi; 284948; -.
DR Pharos; Q7Z4S9; Tdark.
DR PRO; PR:Q7Z4S9; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q7Z4S9; protein.
DR Bgee; ENSG00000152292; Expressed in mucosa of transverse colon and 94 other tissues.
DR ExpressionAtlas; Q7Z4S9; baseline and differential.
DR Genevisible; Q7Z4S9; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; SH2 domain.
FT CHAIN 1..175
FT /note="SH2 domain-containing protein 6"
FT /id="PRO_0000308603"
FT DOMAIN 65..173
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..29
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..36
FT /note="MYASSYPPPPQLSPRSHLCPPPPHPTPPQLNNLLLL -> MPSGPLPRTSVV
FT PRPTTAPQETRNGTADAASK (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_029014"
FT VAR_SEQ 57..84
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_029015"
FT CONFLICT 115
FT /note="I -> T (in Ref. 1; AAR98781)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 175 AA; 19279 MW; 4978232EE5C87FCD CRC64;
MYASSYPPPP QLSPRSHLCP PPPHPTPPQL NNLLLLEGRK SSLPSVAPTG SASAAEDSDL
LTQPWYSGNC DRYAVESALL HLQKDGAYTV RPSSGPHGSQ PFTLAVLLRG RVFNIPIRRL
DGGRHYALGR EGRNREELFS SVAAMVQHFM WHPLPLVDRH SGSRELTCLL FPTKP
