ID   SH2D7_HUMAN             Reviewed;         451 AA.
AC   A6NKC9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=SH2 domain-containing protein 7;
GN   Name=SH2D7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
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DR   EMBL; AC090260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS45315.1; -.
DR   RefSeq; NP_001094874.1; NM_001101404.1.
DR   AlphaFoldDB; A6NKC9; -.
DR   STRING; 9606.ENSP00000327846; -.
DR   iPTMnet; A6NKC9; -.
DR   PhosphoSitePlus; A6NKC9; -.
DR   BioMuta; SH2D7; -.
DR   MassIVE; A6NKC9; -.
DR   PaxDb; A6NKC9; -.
DR   PeptideAtlas; A6NKC9; -.
DR   PRIDE; A6NKC9; -.
DR   Antibodypedia; 62529; 15 antibodies from 6 providers.
DR   DNASU; 646892; -.
DR   Ensembl; ENST00000328828.6; ENSP00000327846.5; ENSG00000183476.13.
DR   GeneID; 646892; -.
DR   KEGG; hsa:646892; -.
DR   MANE-Select; ENST00000328828.6; ENSP00000327846.5; NM_001101404.2; NP_001094874.1.
DR   UCSC; uc010blb.2; human.
DR   CTD; 646892; -.
DR   DisGeNET; 646892; -.
DR   GeneCards; SH2D7; -.
DR   HGNC; HGNC:34549; SH2D7.
DR   HPA; ENSG00000183476; Group enriched (intestine, testis).
DR   neXtProt; NX_A6NKC9; -.
DR   OpenTargets; ENSG00000183476; -.
DR   PharmGKB; PA164725681; -.
DR   VEuPathDB; HostDB:ENSG00000183476; -.
DR   eggNOG; ENOG502QUGN; Eukaryota.
DR   GeneTree; ENSGT00940000160977; -.
DR   HOGENOM; CLU_045989_0_0_1; -.
DR   InParanoid; A6NKC9; -.
DR   OMA; DASPWNL; -.
DR   OrthoDB; 914065at2759; -.
DR   PhylomeDB; A6NKC9; -.
DR   TreeFam; TF337522; -.
DR   PathwayCommons; A6NKC9; -.
DR   SignaLink; A6NKC9; -.
DR   BioGRID-ORCS; 646892; 9 hits in 1068 CRISPR screens.
DR   ChiTaRS; SH2D7; human.
DR   GenomeRNAi; 646892; -.
DR   Pharos; A6NKC9; Tdark.
DR   PRO; PR:A6NKC9; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; A6NKC9; protein.
DR   Bgee; ENSG00000183476; Expressed in mucosa of transverse colon and 67 other tissues.
DR   ExpressionAtlas; A6NKC9; baseline and differential.
DR   CDD; cd10417; SH2_SH2D7; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR035885; SH2D7_SH2.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Reference proteome; SH2 domain.
FT   CHAIN           1..451
FT                   /note="SH2 domain-containing protein 7"
FT                   /id="PRO_0000341254"
FT   DOMAIN          51..142
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          180..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..211
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         137
FT                   /note="M -> T (in dbSNP:rs2289524)"
FT                   /id="VAR_060127"
FT   VARIANT         206
FT                   /note="R -> W (in dbSNP:rs12593575)"
FT                   /id="VAR_060128"
SQ   SEQUENCE   451 AA;  49807 MW;  A931C0905B132AEA CRC64;
     MEDSLKQLSL GRDPEGAGDS QALAELQELA LKWFMETQAP FILQNGALPP WFHGFITRKQ
     TEQLLRDKAL GSFLIRLSDR ATGYILSYRG SDRCRHFVIN QLRNRRYIIS GDTQSHSTLA
     ELVHHYQEAQ LEPFKEMLTA ACPRPEDNDL YDAITRGLHQ TIVDPENPPA TAFLTVVPDK
     AASPRSSPKP QVSFLHAQKS LDVSPRNLSQ EESMEAPIRV SPLPEKSSSL LEESFGGPSD
     IIYADLRRMN QARLGLGTEG SGRHGPVPAG SQAYSPGREA QRRLSDGEQN RPDGLGPVLS
     GVSPDQGPTE SPTSWGCSDA MGSLGATWRQ EFPKLSQEAQ PCSQGSSADI YEFIGTEGLL
     QEARDTPDQE GSTYEQIPAC WGGPARAPHP GASPTYSPWV HGYKRISGTP ELSEPGNTYE
     QIPATKSKET GRTHKPDKLR RLFFTYRKHK F