SH2D7_MOUSE
ID SH2D7_MOUSE Reviewed; 458 AA.
AC Q8BI17;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=SH2 domain-containing protein 7;
GN Name=Sh2d7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-458 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BI17-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BI17-2; Sequence=VSP_034233;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC26825.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CT010507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116842; AAI16843.1; -; mRNA.
DR EMBL; BC116844; AAI16845.1; -; mRNA.
DR EMBL; AK030178; BAC26825.1; ALT_INIT; mRNA.
DR CCDS; CCDS23190.2; -. [Q8BI17-1]
DR RefSeq; NP_776139.1; NM_173778.3. [Q8BI17-1]
DR RefSeq; XP_006511220.1; XM_006511157.1.
DR RefSeq; XP_006511221.1; XM_006511158.1. [Q8BI17-2]
DR AlphaFoldDB; Q8BI17; -.
DR SMR; Q8BI17; -.
DR BioGRID; 232699; 1.
DR STRING; 10090.ENSMUSP00000053690; -.
DR PhosphoSitePlus; Q8BI17; -.
DR PaxDb; Q8BI17; -.
DR PRIDE; Q8BI17; -.
DR ProteomicsDB; 257218; -. [Q8BI17-1]
DR ProteomicsDB; 257219; -. [Q8BI17-2]
DR Antibodypedia; 62529; 15 antibodies from 6 providers.
DR Ensembl; ENSMUST00000060242; ENSMUSP00000053690; ENSMUSG00000046460. [Q8BI17-2]
DR Ensembl; ENSMUST00000118413; ENSMUSP00000113298; ENSMUSG00000046460. [Q8BI17-1]
DR GeneID; 244885; -.
DR KEGG; mmu:244885; -.
DR UCSC; uc009prd.1; mouse. [Q8BI17-1]
DR CTD; 646892; -.
DR MGI; MGI:2441692; Sh2d7.
DR VEuPathDB; HostDB:ENSMUSG00000046460; -.
DR eggNOG; ENOG502QUGN; Eukaryota.
DR GeneTree; ENSGT00940000160977; -.
DR HOGENOM; CLU_045989_0_0_1; -.
DR InParanoid; Q8BI17; -.
DR OMA; DASPWNL; -.
DR OrthoDB; 914065at2759; -.
DR PhylomeDB; Q8BI17; -.
DR TreeFam; TF337522; -.
DR BioGRID-ORCS; 244885; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8BI17; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BI17; protein.
DR Bgee; ENSMUSG00000046460; Expressed in quadriceps femoris and 18 other tissues.
DR CDD; cd10417; SH2_SH2D7; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035885; SH2D7_SH2.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; SH2 domain.
FT CHAIN 1..458
FT /note="SH2 domain-containing protein 7"
FT /id="PRO_0000341255"
FT DOMAIN 51..142
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 204..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..174
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034233"
SQ SEQUENCE 458 AA; 50552 MW; A116403D0B16B597 CRC64;
MEGGPEQLHL GKALEEAGGG RALAEIQELA LKWFMETQAP SILQNGVLPP WFHGFITRKQ
TEQLLRDKAL GSFLIRLSDR AVGYILSYRG SDRCRHFVIN QLRNRRYLVS GDTLSHSTLD
ELLRHYQEVQ LEPFGETLAA ACPRLEENDL YDAINTGLQH TNLSLKIPAT EFPSMLPDKA
TSPRLPAKPQ VSFLHKKALD MSSRSVSDEV SAEVPTRVPP IPRRSPSLLD ESPAGPSDVI
YTDLRKINRA QLGLGTEVWG TLRPASAGSL ACSPGREPSG KLSDEDQNKP NSLGPAPSGM
KPDQGSTMPY TSLGFSLPPS SETLGSQATT WRQGFLKLSH EAQSSSEASS TDTYHLVETP
GLQQEARDRP DQRGSPYEQI PTCWHGTAKL SYPGVSPTYS QQSGPMDYGY EKISGTSKLP
EPGNTYEQIP AAKNKDTGRV HKPDKFRRLF FTDKKHKF
