ABEC4_HUMAN
ID ABEC4_HUMAN Reviewed; 367 AA.
AC Q8WW27; Q8N7F6;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Putative C->U-editing enzyme APOBEC-4;
DE EC=3.5.4.-;
DE AltName: Full=Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4;
GN Name=APOBEC4; Synonyms=C1orf169;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-271 AND GLU-331.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=16082223; DOI=10.4161/cc.4.9.1994;
RA Rogozin I.B., Basu M.K., Jordan I.K., Pavlov Y.I., Koonin E.V.;
RT "APOBEC4, a new member of the AID/APOBEC family of polynucleotide
RT (deoxy)cytidine deaminases predicted by computational analysis.";
RL Cell Cycle 4:1281-1285(2005).
CC -!- FUNCTION: Putative C to U editing enzyme whose physiological substrate
CC is not yet known. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC -!- INTERACTION:
CC Q8WW27; P55212: CASP6; NbExp=3; IntAct=EBI-25836284, EBI-718729;
CC Q8WW27; P62826: RAN; NbExp=3; IntAct=EBI-25836284, EBI-286642;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in testis.
CC {ECO:0000269|PubMed:16082223}.
CC -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC family. {ECO:0000305}.
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DR EMBL; AK098557; BAC05332.1; -; mRNA.
DR EMBL; AL137800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021711; AAH21711.1; -; mRNA.
DR CCDS; CCDS1358.1; -.
DR RefSeq; NP_982279.1; NM_203454.2.
DR AlphaFoldDB; Q8WW27; -.
DR BioGRID; 135625; 3.
DR IntAct; Q8WW27; 2.
DR STRING; 9606.ENSP00000310622; -.
DR iPTMnet; Q8WW27; -.
DR PhosphoSitePlus; Q8WW27; -.
DR BioMuta; APOBEC4; -.
DR DMDM; 74751569; -.
DR MassIVE; Q8WW27; -.
DR PaxDb; Q8WW27; -.
DR PeptideAtlas; Q8WW27; -.
DR PRIDE; Q8WW27; -.
DR ProteomicsDB; 74852; -.
DR Antibodypedia; 2817; 267 antibodies from 28 providers.
DR DNASU; 403314; -.
DR Ensembl; ENST00000308641.6; ENSP00000310622.4; ENSG00000173627.8.
DR GeneID; 403314; -.
DR KEGG; hsa:403314; -.
DR MANE-Select; ENST00000308641.6; ENSP00000310622.4; NM_203454.3; NP_982279.1.
DR UCSC; uc001gqn.4; human.
DR CTD; 403314; -.
DR GeneCards; APOBEC4; -.
DR HGNC; HGNC:32152; APOBEC4.
DR HPA; ENSG00000173627; Group enriched (fallopian tube, testis).
DR MIM; 609908; gene.
DR neXtProt; NX_Q8WW27; -.
DR OpenTargets; ENSG00000173627; -.
DR PharmGKB; PA142672597; -.
DR VEuPathDB; HostDB:ENSG00000173627; -.
DR eggNOG; ENOG502QQXT; Eukaryota.
DR GeneTree; ENSGT00390000014243; -.
DR HOGENOM; CLU_832944_0_0_1; -.
DR OMA; VRHLNMP; -.
DR OrthoDB; 1149880at2759; -.
DR PhylomeDB; Q8WW27; -.
DR TreeFam; TF338173; -.
DR PathwayCommons; Q8WW27; -.
DR Reactome; R-HSA-72200; mRNA Editing: C to U Conversion.
DR Reactome; R-HSA-75094; Formation of the Editosome.
DR SignaLink; Q8WW27; -.
DR BioGRID-ORCS; 403314; 27 hits in 1061 CRISPR screens.
DR ChiTaRS; APOBEC4; human.
DR GeneWiki; APOBEC4; -.
DR GenomeRNAi; 403314; -.
DR Pharos; Q8WW27; Tdark.
DR PRO; PR:Q8WW27; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8WW27; protein.
DR Bgee; ENSG00000173627; Expressed in bronchial epithelial cell and 39 other tissues.
DR Genevisible; Q8WW27; HS.
DR GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR038953; APOBEC4.
DR InterPro; IPR013158; APOBEC_N.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR PANTHER; PTHR35672; PTHR35672; 1.
DR Pfam; PF08210; APOBEC_N; 1.
DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE 1: Evidence at protein level;
KW Hydrolase; Metal-binding; mRNA processing; Reference proteome; Zinc.
FT CHAIN 1..367
FT /note="Putative C->U-editing enzyme APOBEC-4"
FT /id="PRO_0000239355"
FT DOMAIN 61..177
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01083"
FT ACT_SITE 95
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 127
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 134
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT VARIANT 75
FT /note="S -> F (in dbSNP:rs16861394)"
FT /id="VAR_026639"
FT VARIANT 271
FT /note="F -> S (in dbSNP:rs1174658)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_026640"
FT VARIANT 275
FT /note="P -> S (in dbSNP:rs10911391)"
FT /id="VAR_026641"
FT VARIANT 300
FT /note="D -> G (in dbSNP:rs16861381)"
FT /id="VAR_048724"
FT VARIANT 331
FT /note="K -> E (in dbSNP:rs1174657)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_026642"
FT VARIANT 345
FT /note="V -> M (in dbSNP:rs10911390)"
FT /id="VAR_026643"
SQ SEQUENCE 367 AA; 41581 MW; B5ACD9AB875482C6 CRC64;
MEPIYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVSLTEFCQ IFGFPYGTTF
PQTKHLTFYE LKTSSGSLVQ KGHASSCTGN YIHPESMLFE MNGYLDSAIY NNDSIRHIIL
YSNNSPCNEA NHCCISKMYN FLITYPGITL SIYFSQLYHT EMDFPASAWN REALRSLASL
WPRVVLSPIS GGIWHSVLHS FISGVSGSHV FQPILTGRAL ADRHNAYEIN AITGVKPYFT
DVLLQTKRNP NTKAQEALES YPLNNAFPGQ FFQMPSGQLQ PNLPPDLRAP VVFVLVPLRD
LPPMHMGQNP NKPRNIVRHL NMPQMSFQET KDLGRLPTGR SVEIVEITEQ FASSKEADEK
KKKKGKK
