ID   SH321_MACFA             Reviewed;         692 AA.
AC   Q4R729; Q4R357;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=SH3 domain-containing protein 21;
GN   Name=SH3D21; ORFNames=QtsA-16465, QtsA-19407;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q4R729-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q4R729-2; Sequence=VSP_033933, VSP_033934, VSP_033935;
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DR   EMBL; AB169000; BAE01095.1; -; mRNA.
DR   EMBL; AB179411; BAE02462.1; -; mRNA.
DR   AlphaFoldDB; Q4R729; -.
DR   STRING; 9541.XP_005544016.1; -.
DR   eggNOG; KOG4348; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   CDD; cd12142; SH3_D21-like; 1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035468; SH3D21_SH3.
DR   Pfam; PF07653; SH3_2; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Reference proteome; SH3 domain.
FT   CHAIN           1..692
FT                   /note="SH3 domain-containing protein 21"
FT                   /id="PRO_0000337130"
FT   DOMAIN          65..126
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          536..605
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          672..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          628..678
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        167..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..394
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..499
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        548..581
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..266
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_033933"
FT   VAR_SEQ         267..269
FT                   /note="VPS -> MAA (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_033934"
FT   VAR_SEQ         524..558
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_033935"
FT   CONFLICT        334
FT                   /note="S -> F (in Ref. 1; BAE02462)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        494
FT                   /note="L -> P (in Ref. 1; BAE02462)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        497
FT                   /note="G -> E (in Ref. 1; BAE02462)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        563
FT                   /note="G -> E (in Ref. 1; BAE02462)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   692 AA;  75170 MW;  5071D53A828FE765 CRC64;
     MVQSELQLQP RAGGRAEAAS WGDRGNDKGG FGNPDMPSVS PGPQRPPKLS SLAYDSPPDY
     LQTVSHPEAY RVLFDYQPEA PDELTLRRGD VVKVLSKTTE DKGWWEGECQ GRRGVFPDNF
     VLPPPPIKKL VPRKVVSRQS APIKEPKKLM PKTSLPTVKK LATAATGPSK AKTSRTPSRD
     SQKLTSRDSG PNGGFQSGGS CPPGRKRSKT QTPQQRSVSS QEEEHSSPAK APSVKRTPML
     DKTTTPERPP APENAPGSKK IPVPDKVPSP EKTLTLGDKA SIPGNSTSGK IPGPDIVPTP
     ERMVTPEDKA SIPENSIPEE ALTVDKPSTP ERLSSVEEAS GPEVPPMDKV PDPKMAPLGD
     EAPTREKVLT PELSEEEVST RDDTQFHHFS SEEALQKVKS FVAKEAPSSQ EKAHTPEAPP
     LQPPSSEKCL GEMKCPLVRG DSSPHQAELK SGPASRPALE KPHPQAEATT LLEEAPSKEE
     RTPEEEASPN EERLLRGEVL PKEGVASKGE VLPKEGVASK GEVLPKEGVA SKEVLPKGGV
     ASKEEVLPKE GVASKEEMLP KEGVASKEEV TLKEEVAPKE EVPPIDTAFA QKTHPIKPSP
     DSQETLTLPS LLPQNYTENK NEGVDVTSLR GEVESLRRAL ELMGVQLERK LTDIWEELKS
     EKEQRQRLEV QVMQGTQKSQ TPRIIHAQTQ TY