SH321_MOUSE
ID SH321_MOUSE Reviewed; 549 AA.
AC Q7TSG5; B1AW04; Q3U2S3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=SH3 domain-containing protein 21;
GN Name=Sh3d21;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7TSG5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TSG5-2; Sequence=VSP_033936;
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DR EMBL; AK155132; BAE33067.1; -; mRNA.
DR EMBL; AL731780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC053421; AAH53421.1; -; mRNA.
DR CCDS; CCDS18644.1; -. [Q7TSG5-1]
DR CCDS; CCDS51301.1; -. [Q7TSG5-2]
DR RefSeq; NP_080132.1; NM_025856.3. [Q7TSG5-1]
DR RefSeq; XP_006503358.1; XM_006503295.2.
DR AlphaFoldDB; Q7TSG5; -.
DR SMR; Q7TSG5; -.
DR BioGRID; 211823; 2.
DR IntAct; Q7TSG5; 1.
DR MINT; Q7TSG5; -.
DR STRING; 10090.ENSMUSP00000095501; -.
DR iPTMnet; Q7TSG5; -.
DR PhosphoSitePlus; Q7TSG5; -.
DR MaxQB; Q7TSG5; -.
DR PaxDb; Q7TSG5; -.
DR PRIDE; Q7TSG5; -.
DR ProteomicsDB; 261342; -. [Q7TSG5-1]
DR ProteomicsDB; 261343; -. [Q7TSG5-2]
DR Antibodypedia; 51050; 60 antibodies from 10 providers.
DR DNASU; 66938; -.
DR Ensembl; ENSMUST00000094760; ENSMUSP00000092352; ENSMUSG00000073758. [Q7TSG5-1]
DR GeneID; 66938; -.
DR KEGG; mmu:66938; -.
DR UCSC; uc008usq.2; mouse. [Q7TSG5-1]
DR CTD; 79729; -.
DR MGI; MGI:1914188; Sh3d21.
DR VEuPathDB; HostDB:ENSMUSG00000073758; -.
DR eggNOG; KOG4348; Eukaryota.
DR GeneTree; ENSGT00940000160627; -.
DR InParanoid; Q7TSG5; -.
DR PhylomeDB; Q7TSG5; -.
DR TreeFam; TF338545; -.
DR BioGRID-ORCS; 66938; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Sh3d21; mouse.
DR PRO; PR:Q7TSG5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q7TSG5; protein.
DR Bgee; ENSMUSG00000073758; Expressed in seminiferous tubule of testis and 208 other tissues.
DR ExpressionAtlas; Q7TSG5; baseline and differential.
DR Genevisible; Q7TSG5; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR CDD; cd12142; SH3_D21-like; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035468; SH3D21_SH3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome; SH3 domain.
FT CHAIN 1..549
FT /note="SH3 domain-containing protein 21"
FT /id="PRO_0000337131"
FT DOMAIN 65..126
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 482..510
FT /evidence="ECO:0000255"
FT COMPBIAS 171..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..30
FT /note="MVQSELQLQPRAGRRADASNWGDFGSDKGG -> MEVLVLARYRAQTEDELS
FT LAPGDVIRQVCAGPARGWLLGELRGRRGRFPKRLVREIPEALRGVTESRPRFPRRSRRH
FT PINSRDPQRWCRVNFNYSPEQADELTLQTGEILEVIKEIEDGWWLGEKNGQLGAFPSNF
FT VELLDSGPPS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033936"
SQ SEQUENCE 549 AA; 60324 MW; 0B4EE496ACB6CBB2 CRC64;
MVQSELQLQP RAGRRADASN WGDFGSDKGG LGNTDIPPIT PNSQRPPKLS NLTYDSPPDY
LRTVSCPETC RVLFDYQPEA PDELALQKGD LVKVLRKTTE DKGWWEGECQ GRRGVFPDNF
VIPPPPIRKL IPRKIISRES APIKETKKLM PKSSLPTVKK LAAAASAPGR AKTLSTPSGD
SQKRPSRNSG FNGSCLNGGP RQPGRKGSRT QASQQHSASS QEDEQKSPGK GPSRSKTPTP
EKTRLPDKVL APETIPAPDK VSIPKDPVPK KAPDSDKIPA TEDTTLDKAG TPESTLSGNK
PAKDEALDLK MALHEDTAPA LVKILTPEHM IFKKEPSRDN DQCQHLPQGG STQRPESPAP
SNNIQVPGEY SPPPDSSERS CCRVRQVNGS FPAQSKAEDV SAMEEANFLE EPLAKDERTL
NKALPKKLPS ERAGPQKQVL PQESAPTPQV PHTIQQMPVP EEAPTLHPLT PLTSPKSKND
RMDVLESLKE EVGLLRSRLE LLELKLEQKM GDVWEELKTE TLLSPEVQMM QRNRKSFKHA
ETQTETQTE
