SH3BG_DROME
ID SH3BG_DROME Reviewed; 158 AA.
AC Q9NFP5; Q0E8H4; Q9VS58;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=SH3 domain-binding glutamic acid-rich protein homolog;
DE Short=SH3BGR protein;
GN Name=Sh3beta; Synonyms=SH3BGR; ORFNames=CG8582;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RA Scartezzini P., Egeo A., Mazzocco M.;
RT "Cloning of the Drosophila Sh3bgr gene homolog of human Sh3bgr gene.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-109, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
CC -!- INTERACTION:
CC Q9NFP5; Q9VY28: mRpS25; NbExp=2; IntAct=EBI-3431675, EBI-3429710;
CC -!- SIMILARITY: Belongs to the SH3BGR family. {ECO:0000305}.
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DR EMBL; AJ272505; CAB76915.1; -; mRNA.
DR EMBL; AE014296; AAN12061.1; -; Genomic_DNA.
DR EMBL; AY061162; AAL28710.1; -; mRNA.
DR RefSeq; NP_648112.2; NM_139855.4.
DR RefSeq; NP_729248.1; NM_168210.3.
DR AlphaFoldDB; Q9NFP5; -.
DR SMR; Q9NFP5; -.
DR BioGRID; 64260; 94.
DR IntAct; Q9NFP5; 4.
DR STRING; 7227.FBpp0291704; -.
DR iPTMnet; Q9NFP5; -.
DR PaxDb; Q9NFP5; -.
DR PRIDE; Q9NFP5; -.
DR DNASU; 38820; -.
DR EnsemblMetazoa; FBtr0076872; FBpp0076582; FBgn0035772.
DR EnsemblMetazoa; FBtr0076873; FBpp0076583; FBgn0035772.
DR GeneID; 38820; -.
DR KEGG; dme:Dmel_CG8582; -.
DR UCSC; CG8582-RA; d. melanogaster.
DR CTD; 38820; -.
DR FlyBase; FBgn0035772; Sh3beta.
DR VEuPathDB; VectorBase:FBgn0035772; -.
DR eggNOG; KOG4023; Eukaryota.
DR GeneTree; ENSGT00940000173996; -.
DR HOGENOM; CLU_084862_1_1_1; -.
DR InParanoid; Q9NFP5; -.
DR PhylomeDB; Q9NFP5; -.
DR BioGRID-ORCS; 38820; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Sh3beta; fly.
DR GenomeRNAi; 38820; -.
DR PRO; PR:Q9NFP5; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035772; Expressed in wing disc and 26 other tissues.
DR ExpressionAtlas; Q9NFP5; baseline and differential.
DR Genevisible; Q9NFP5; DM.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR CDD; cd03030; GRX_SH3BGR; 1.
DR InterPro; IPR006993; Glut_rich_SH3-bd.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF04908; SH3BGR; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; SH3-binding.
FT CHAIN 1..158
FT /note="SH3 domain-binding glutamic acid-rich protein
FT homolog"
FT /id="PRO_0000220751"
FT REGION 40..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 67..73
FT /note="SH3-binding"
FT /evidence="ECO:0000255"
FT COMPBIAS 120..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 109
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT CONFLICT 13..14
FT /note="NK -> LL (in Ref. 1; CAB76915)"
FT /evidence="ECO:0000305"
FT CONFLICT 20..21
FT /note="QQ -> HE (in Ref. 1; CAB76915)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="D -> V (in Ref. 1; CAB76915)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 158 AA; 17488 MW; 9DEF79C3D48CA463 CRC64;
MVLKVYVSGM SGNKEVKKRQ QRVLMILDSK NIKYDTVDIT EPGKESEKEL MQNKSTSNGG
TVSDPEPRHP LPPQLFNDDE YCGDYDAFDM ANEIDTLEVF LKLAPADTTA VSTAQIELKQ
ENGDAKKEEA ETEAEDKKTE AGDGDVDVKE EAAEKAEV
