SH3BG_MOUSE
ID SH3BG_MOUSE Reviewed; 214 AA.
AC Q9WUZ7;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=SH3 domain-binding glutamic acid-rich protein;
DE Short=SH3BGR protein;
GN Name=Sh3bgr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal heart;
RA Scartezzini P.;
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the SH3BGR family. {ECO:0000305}.
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DR EMBL; AJ239082; CAB44710.1; -; mRNA.
DR CCDS; CCDS28355.1; -.
DR RefSeq; NP_056640.1; NM_015825.2.
DR AlphaFoldDB; Q9WUZ7; -.
DR SMR; Q9WUZ7; -.
DR STRING; 10090.ENSMUSP00000038110; -.
DR iPTMnet; Q9WUZ7; -.
DR PhosphoSitePlus; Q9WUZ7; -.
DR MaxQB; Q9WUZ7; -.
DR PaxDb; Q9WUZ7; -.
DR PRIDE; Q9WUZ7; -.
DR ProteomicsDB; 261022; -.
DR DNASU; 50795; -.
DR Ensembl; ENSMUST00000048770; ENSMUSP00000038110; ENSMUSG00000040666.
DR Ensembl; ENSMUST00000171181; ENSMUSP00000126581; ENSMUSG00000040666.
DR GeneID; 50795; -.
DR KEGG; mmu:50795; -.
DR UCSC; uc008acu.1; mouse.
DR CTD; 6450; -.
DR MGI; MGI:1354740; Sh3bgr.
DR VEuPathDB; HostDB:ENSMUSG00000040666; -.
DR eggNOG; KOG4023; Eukaryota.
DR GeneTree; ENSGT00940000159847; -.
DR HOGENOM; CLU_084862_0_1_1; -.
DR InParanoid; Q9WUZ7; -.
DR OMA; VKMVIKV; -.
DR OrthoDB; 1508713at2759; -.
DR PhylomeDB; Q9WUZ7; -.
DR TreeFam; TF105574; -.
DR BioGRID-ORCS; 50795; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Sh3bgr; mouse.
DR PRO; PR:Q9WUZ7; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9WUZ7; protein.
DR Bgee; ENSMUSG00000040666; Expressed in triceps brachii and 187 other tissues.
DR ExpressionAtlas; Q9WUZ7; baseline and differential.
DR Genevisible; Q9WUZ7; MM.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR CDD; cd03030; GRX_SH3BGR; 1.
DR InterPro; IPR006993; Glut_rich_SH3-bd.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF04908; SH3BGR; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW Reference proteome; SH3-binding.
FT CHAIN 1..214
FT /note="SH3 domain-binding glutamic acid-rich protein"
FT /id="PRO_0000220744"
FT REGION 101..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 61..67
FT /note="SH3-binding"
FT /evidence="ECO:0000255"
FT COMPBIAS 125..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..214
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 214 AA; 23102 MW; 1F5D2AEF005ED48D CRC64;
MVIKVFVATS SGSIAIRKKQ QEVVGFLEAN KIDFKELDIA GDEDNRKWMR ENVPGEKKPQ
NGIPLPPQIF NEEQYCGDFD SFFSAKEENI IYSFLGLAPP PGSKVTKSEE ASSLPNGDVA
GEAEGAAEGT EKAEKSGENE AQKEDSEDTG ELSESQEKKE EEGEDGEEGE EGEEREEGGE
GETTGETEEA PEEGAGGEAE EEEPEEEAGE GEDS
