SH3G3_DROPS
ID SH3G3_DROPS Reviewed; 369 AA.
AC Q8I1C0;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Endophilin-A;
DE AltName: Full=SH3 domain-containing GRB2-like protein;
GN Name=EndoA {ECO:0000250|UniProtKB:Q8T390}; ORFNames=GA12885;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:AAO01051.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14011-0121.4 {ECO:0000312|EMBL:AAO01051.1};
RX PubMed=12537575; DOI=10.1186/gb-2002-3-12-research0086;
RA Bergman C.M., Pfeiffer B.D., Rincon-Limas D.E., Hoskins R.A., Gnirke A.,
RA Mungall C.J., Wang A.M., Kronmiller B., Pacleb J.M., Park S., Stapleton M.,
RA Wan K.H., George R.A., de Jong P.J., Botas J., Rubin G.M., Celniker S.E.;
RT "Assessing the impact of comparative genomic sequence data on the
RT functional annotation of the Drosophila genome.";
RL Genome Biol. 3:RESEARCH0086.1-RESEARCH0086.20(2002).
RN [2] {ECO:0000312|EMBL:EAL28006.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Required presynaptically at the neuromuscular junction.
CC Implicated in synaptic vesicle endocytosis.
CC {ECO:0000250|UniProtKB:Q8T390}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8T390}.
CC Membrane {ECO:0000250|UniProtKB:Q8T390}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q8T390}. Note=Associated with internal
CC membranes. Expressed presynaptically at NMJs.
CC {ECO:0000250|UniProtKB:Q8T390}.
CC -!- SIMILARITY: Belongs to the endophilin family. {ECO:0000255}.
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DR EMBL; AY190947; AAO01051.1; -; Genomic_DNA.
DR EMBL; CM000070; EAL28006.1; -; Genomic_DNA.
DR RefSeq; XP_001358863.1; XM_001358826.3.
DR RefSeq; XP_015037404.1; XM_015181918.1.
DR AlphaFoldDB; Q8I1C0; -.
DR SMR; Q8I1C0; -.
DR STRING; 7237.FBpp0284043; -.
DR EnsemblMetazoa; FBtr0285605; FBpp0284043; FBgn0064416.
DR EnsemblMetazoa; FBtr0380938; FBpp0341278; FBgn0064416.
DR GeneID; 4801830; -.
DR KEGG; dpo:Dpse_GA12885; -.
DR eggNOG; KOG1118; Eukaryota.
DR HOGENOM; CLU_047887_0_0_1; -.
DR InParanoid; Q8I1C0; -.
DR OMA; QYLSETM; -.
DR PhylomeDB; Q8I1C0; -.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0064416; Expressed in insect adult head and 2 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061174; C:type I terminal bouton; IEA:EnsemblMetazoa.
DR GO; GO:0042171; F:lysophosphatidic acid acyltransferase activity; ISS:UniProtKB.
DR GO; GO:0005543; F:phospholipid binding; IEA:EnsemblMetazoa.
DR GO; GO:0000045; P:autophagosome assembly; IEA:EnsemblMetazoa.
DR GO; GO:0009267; P:cellular response to starvation; IEA:EnsemblMetazoa.
DR GO; GO:0150007; P:clathrin-dependent synaptic vesicle endocytosis; IEA:EnsemblMetazoa.
DR GO; GO:0097753; P:membrane bending; IEA:EnsemblMetazoa.
DR GO; GO:0097749; P:membrane tubulation; IEA:EnsemblMetazoa.
DR GO; GO:0097320; P:plasma membrane tubulation; IEA:EnsemblMetazoa.
DR GO; GO:0050803; P:regulation of synapse structure or activity; ISS:UniProtKB.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.
DR CDD; cd11803; SH3_Endophilin_A; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR028501; Endophilin-A.
DR InterPro; IPR035824; Endophilin_A_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF45; PTHR14167:SF45; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Endocytosis; Membrane; Phosphoprotein;
KW Reference proteome; SH3 domain.
FT CHAIN 1..369
FT /note="Endophilin-A"
FT /id="PRO_0000285839"
FT DOMAIN 18..248
FT /note="BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT DOMAIN 305..364
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 275..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 227..247
FT /evidence="ECO:0000255"
FT COMPBIAS 276..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 369 AA; 41387 MW; 21DCE7FFF4EED940 CRC64;
MAFAGLKKQI NKANQYMTEK MGGAEGTKLD MDFMDMERKT DVTVELVEEL QLKTKEFLQP
NPTARAKMAA VKGISKLSGQ AKSNTYPQPE GLLAECMLTY GKKLGEDNSV FAQALVEFGE
SLKQMADVKY SLDDNIKQNF LEPLHHMQMK DLKEVMHHRK KLQGRRLDFD CKRRRQAKDD
EIRGAEDKFA ESLQLAQVGM FNLLENDTEH VSQLVTFAEA LYDFHSQCAD VLRGLQETLQ
EKRSEAESRP RNEFVPKTLL DLNLDGGGGG LIDDGTPSHI SSSASPLPSP MRSPAKSMAV
TPSRQQQPCC QALYDFDPEN PGELGFKEND IITLLNRVDD NWYEGAVNGR TGYFPQSYVQ
VQVPLPNGN
