SH3L1_MOUSE
ID SH3L1_MOUSE Reviewed; 114 AA.
AC Q9JJU8; A2ALN7; Q3UB57;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=SH3 domain-binding glutamic acid-rich-like protein;
GN Name=Sh3bgrl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Scartezzini P., Egeo A., Mazzocco M.;
RT "Cloning the mouse homolog of the human SH3BGRL gene.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Hippocampus, Lung, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the SH3BGR family. {ECO:0000305}.
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DR EMBL; AJ272504; CAB76919.1; -; mRNA.
DR EMBL; AK049929; BAC33989.1; -; mRNA.
DR EMBL; AK146588; BAE27283.1; -; mRNA.
DR EMBL; AK151095; BAE30107.1; -; mRNA.
DR EMBL; AK151501; BAE30452.1; -; mRNA.
DR EMBL; AK165995; BAE38507.1; -; mRNA.
DR EMBL; AL805929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034161; AAH34161.1; -; mRNA.
DR EMBL; BC043055; AAH43055.1; -; mRNA.
DR CCDS; CCDS41102.1; -.
DR RefSeq; NP_064373.1; NM_019989.2.
DR AlphaFoldDB; Q9JJU8; -.
DR SMR; Q9JJU8; -.
DR BioGRID; 208146; 1.
DR STRING; 10090.ENSMUSP00000033598; -.
DR iPTMnet; Q9JJU8; -.
DR PhosphoSitePlus; Q9JJU8; -.
DR SwissPalm; Q9JJU8; -.
DR CPTAC; non-CPTAC-3672; -.
DR EPD; Q9JJU8; -.
DR jPOST; Q9JJU8; -.
DR MaxQB; Q9JJU8; -.
DR PaxDb; Q9JJU8; -.
DR PeptideAtlas; Q9JJU8; -.
DR PRIDE; Q9JJU8; -.
DR ProteomicsDB; 256997; -.
DR Antibodypedia; 28352; 198 antibodies from 27 providers.
DR DNASU; 56726; -.
DR Ensembl; ENSMUST00000033598; ENSMUSP00000033598; ENSMUSG00000031246.
DR GeneID; 56726; -.
DR KEGG; mmu:56726; -.
DR UCSC; uc009uct.1; mouse.
DR CTD; 6451; -.
DR MGI; MGI:1930849; Sh3bgrl.
DR VEuPathDB; HostDB:ENSMUSG00000031246; -.
DR eggNOG; KOG4023; Eukaryota.
DR GeneTree; ENSGT00940000156017; -.
DR HOGENOM; CLU_084862_3_0_1; -.
DR InParanoid; Q9JJU8; -.
DR OMA; NEKEFMQ; -.
DR OrthoDB; 1508713at2759; -.
DR PhylomeDB; Q9JJU8; -.
DR TreeFam; TF105574; -.
DR BioGRID-ORCS; 56726; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Sh3bgrl; mouse.
DR PRO; PR:Q9JJU8; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9JJU8; protein.
DR Bgee; ENSMUSG00000031246; Expressed in medial ganglionic eminence and 263 other tissues.
DR Genevisible; Q9JJU8; MM.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR CDD; cd03030; GRX_SH3BGR; 1.
DR InterPro; IPR006993; Glut_rich_SH3-bd.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF04908; SH3BGR; 1.
DR PIRSF; PIRSF008142; SH3-bind_E-rich_L; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW Reference proteome; SH3-binding.
FT CHAIN 1..114
FT /note="SH3 domain-binding glutamic acid-rich-like protein"
FT /id="PRO_0000220746"
FT MOTIF 61..67
FT /note="SH3-binding"
FT /evidence="ECO:0000255"
SQ SEQUENCE 114 AA; 12811 MW; D7298AF8F5BFA43F CRC64;
MVIRVYIASS SGSTAIKKKQ QDVLCFLEAN KIGFEEKDIA ANEENRKWMR ENVPEDSRPS
TGYPLPPQIF NECQYRGDYD AFFEARENNA VYAFLGLTAP PGSKEAEAQA NQQA
