ID   SH3L2_MOUSE             Reviewed;         107 AA.
AC   Q8BG73; Q3TV64;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=SH3 domain-binding glutamic acid-rich-like protein 2;
GN   Name=Sh3bgrl2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Placenta, and Retina;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N-3;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 58-86, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Hippocampus;
RA   Lubec G., Klug S.;
RL   Submitted (MAR-2007) to UniProtKB.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Kidney, Liver, Pancreas, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SH3BGR family. {ECO:0000305}.
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DR   EMBL; BC038473; AAH38473.1; -; mRNA.
DR   EMBL; AK076202; BAC36251.1; -; mRNA.
DR   EMBL; AK160357; BAE35756.1; -; mRNA.
DR   CCDS; CCDS40708.1; -.
DR   RefSeq; NP_766095.1; NM_172507.5.
DR   AlphaFoldDB; Q8BG73; -.
DR   SMR; Q8BG73; -.
DR   BioGRID; 229337; 1.
DR   IntAct; Q8BG73; 1.
DR   MINT; Q8BG73; -.
DR   STRING; 10090.ENSMUSP00000108841; -.
DR   iPTMnet; Q8BG73; -.
DR   PhosphoSitePlus; Q8BG73; -.
DR   jPOST; Q8BG73; -.
DR   MaxQB; Q8BG73; -.
DR   PaxDb; Q8BG73; -.
DR   PeptideAtlas; Q8BG73; -.
DR   PRIDE; Q8BG73; -.
DR   ProteomicsDB; 261211; -.
DR   Antibodypedia; 64235; 27 antibodies from 15 providers.
DR   DNASU; 212531; -.
DR   Ensembl; ENSMUST00000113215; ENSMUSP00000108841; ENSMUSG00000032261.
DR   GeneID; 212531; -.
DR   KEGG; mmu:212531; -.
DR   UCSC; uc009qwl.1; mouse.
DR   CTD; 83699; -.
DR   MGI; MGI:1915350; Sh3bgrl2.
DR   VEuPathDB; HostDB:ENSMUSG00000032261; -.
DR   eggNOG; KOG4023; Eukaryota.
DR   GeneTree; ENSGT00940000159157; -.
DR   HOGENOM; CLU_084862_3_0_1; -.
DR   InParanoid; Q8BG73; -.
DR   OMA; MYKNIPK; -.
DR   OrthoDB; 1508713at2759; -.
DR   PhylomeDB; Q8BG73; -.
DR   TreeFam; TF105574; -.
DR   BioGRID-ORCS; 212531; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Sh3bgrl2; mouse.
DR   PRO; PR:Q8BG73; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q8BG73; protein.
DR   Bgee; ENSMUSG00000032261; Expressed in urinary bladder urothelium and 224 other tissues.
DR   ExpressionAtlas; Q8BG73; baseline and differential.
DR   Genevisible; Q8BG73; MM.
DR   GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   CDD; cd03030; GRX_SH3BGR; 1.
DR   InterPro; IPR006993; Glut_rich_SH3-bd.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF04908; SH3BGR; 1.
DR   PIRSF; PIRSF008142; SH3-bind_E-rich_L; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Nucleus; Reference proteome; SH3-binding.
FT   CHAIN           1..107
FT                   /note="SH3 domain-binding glutamic acid-rich-like protein
FT                   2"
FT                   /id="PRO_0000220748"
FT   MOTIF           61..67
FT                   /note="SH3-binding"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   107 AA;  12255 MW;  BADE6662937029EF CRC64;
     MVVRVFVASC SGFVAIKKKQ QDVVRFLEAN KIEFEEVDIT MSEEQRQWMY KNIPPEKKPA
     QGNPLPPQIF NGDRYCGDYD SFFESKESNT VFSFLGLKPR PASTAEP