SH3Y1_HUMAN
ID SH3Y1_HUMAN Reviewed; 342 AA.
AC Q96HL8; A8K8E7; B7WNJ4; B7WPL6; Q8NEL2; Q9H5X4; Q9Y3V5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=SH3 domain-containing YSC84-like protein 1;
GN Name=SH3YL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Carcinoma, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5).
RC TISSUE=Testis, and Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP STRUCTURE BY NMR OF 273-342.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the SH3 domain of hypothetical protein SH3YL1.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- SUBUNIT: Interacts with SH3D19. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96HL8; P14136: GFAP; NbExp=4; IntAct=EBI-722667, EBI-744302;
CC Q96HL8; Q5HYK7: SH3D19; NbExp=3; IntAct=EBI-722667, EBI-2563437;
CC Q96HL8; Q5HYK7-2: SH3D19; NbExp=7; IntAct=EBI-722667, EBI-14699032;
CC Q96HL8; Q9H9H4: VPS37B; NbExp=7; IntAct=EBI-722667, EBI-4400866;
CC Q96HL8; O15156: ZBTB7B; NbExp=3; IntAct=EBI-722667, EBI-740434;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q96HL8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96HL8-2; Sequence=VSP_034335;
CC Name=3;
CC IsoId=Q96HL8-3; Sequence=VSP_034332, VSP_034333;
CC Name=4;
CC IsoId=Q96HL8-4; Sequence=VSP_034332, VSP_034333, VSP_034335;
CC Name=5;
CC IsoId=Q96HL8-5; Sequence=VSP_034334;
CC -!- SIMILARITY: Belongs to the SH3YL1 family. {ECO:0000305}.
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DR EMBL; AK026507; BAB15493.1; -; mRNA.
DR EMBL; AK292312; BAF85001.1; -; mRNA.
DR EMBL; CR457361; CAG33642.1; -; mRNA.
DR EMBL; AL050373; CAB43679.2; -; mRNA.
DR EMBL; AC079779; AAY14957.1; -; Genomic_DNA.
DR EMBL; BC008374; AAH08374.1; -; mRNA.
DR EMBL; BC008375; AAH08375.1; -; mRNA.
DR EMBL; BC030778; AAH30778.1; -; mRNA.
DR EMBL; BC034974; AAH34974.1; -; mRNA.
DR CCDS; CCDS42646.2; -. [Q96HL8-1]
DR CCDS; CCDS54332.1; -. [Q96HL8-2]
DR CCDS; CCDS62841.1; -. [Q96HL8-4]
DR CCDS; CCDS62842.1; -. [Q96HL8-3]
DR RefSeq; NP_001153069.1; NM_001159597.2. [Q96HL8-2]
DR RefSeq; NP_001269611.1; NM_001282682.1. [Q96HL8-4]
DR RefSeq; NP_001269616.1; NM_001282687.1. [Q96HL8-3]
DR RefSeq; NP_056492.2; NM_015677.3. [Q96HL8-1]
DR PDB; 2D8H; NMR; -; A=276-342.
DR PDBsum; 2D8H; -.
DR AlphaFoldDB; Q96HL8; -.
DR BMRB; Q96HL8; -.
DR SMR; Q96HL8; -.
DR BioGRID; 117811; 14.
DR IntAct; Q96HL8; 8.
DR MINT; Q96HL8; -.
DR STRING; 9606.ENSP00000348471; -.
DR iPTMnet; Q96HL8; -.
DR PhosphoSitePlus; Q96HL8; -.
DR BioMuta; SH3YL1; -.
DR DMDM; 74751912; -.
DR EPD; Q96HL8; -.
DR jPOST; Q96HL8; -.
DR MassIVE; Q96HL8; -.
DR PaxDb; Q96HL8; -.
DR PeptideAtlas; Q96HL8; -.
DR PRIDE; Q96HL8; -.
DR ProteomicsDB; 76760; -. [Q96HL8-1]
DR ProteomicsDB; 76761; -. [Q96HL8-2]
DR ProteomicsDB; 76762; -. [Q96HL8-3]
DR ProteomicsDB; 76763; -. [Q96HL8-4]
DR ProteomicsDB; 76764; -. [Q96HL8-5]
DR Antibodypedia; 49866; 39 antibodies from 13 providers.
DR DNASU; 26751; -.
DR Ensembl; ENST00000356150.10; ENSP00000348471.5; ENSG00000035115.22. [Q96HL8-1]
DR Ensembl; ENST00000402632.5; ENSP00000384910.1; ENSG00000035115.22. [Q96HL8-5]
DR Ensembl; ENST00000403657.5; ENSP00000385668.1; ENSG00000035115.22. [Q96HL8-4]
DR Ensembl; ENST00000403658.5; ENSP00000383928.1; ENSG00000035115.22. [Q96HL8-4]
DR Ensembl; ENST00000403712.6; ENSP00000384276.1; ENSG00000035115.22. [Q96HL8-2]
DR Ensembl; ENST00000405430.5; ENSP00000384269.1; ENSG00000035115.22. [Q96HL8-1]
DR Ensembl; ENST00000626873.2; ENSP00000485824.1; ENSG00000035115.22. [Q96HL8-3]
DR GeneID; 26751; -.
DR KEGG; hsa:26751; -.
DR MANE-Select; ENST00000356150.10; ENSP00000348471.5; NM_015677.4; NP_056492.2.
DR UCSC; uc002qvx.5; human. [Q96HL8-1]
DR CTD; 26751; -.
DR DisGeNET; 26751; -.
DR GeneCards; SH3YL1; -.
DR HGNC; HGNC:29546; SH3YL1.
DR HPA; ENSG00000035115; Low tissue specificity.
DR neXtProt; NX_Q96HL8; -.
DR OpenTargets; ENSG00000035115; -.
DR PharmGKB; PA128394643; -.
DR VEuPathDB; HostDB:ENSG00000035115; -.
DR eggNOG; KOG1843; Eukaryota.
DR GeneTree; ENSGT00510000048137; -.
DR HOGENOM; CLU_015320_2_1_1; -.
DR InParanoid; Q96HL8; -.
DR OMA; NDAMYND; -.
DR OrthoDB; 1090526at2759; -.
DR PhylomeDB; Q96HL8; -.
DR TreeFam; TF331022; -.
DR PathwayCommons; Q96HL8; -.
DR SignaLink; Q96HL8; -.
DR BioGRID-ORCS; 26751; 9 hits in 1075 CRISPR screens.
DR ChiTaRS; SH3YL1; human.
DR EvolutionaryTrace; Q96HL8; -.
DR GenomeRNAi; 26751; -.
DR Pharos; Q96HL8; Tdark.
DR PRO; PR:Q96HL8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96HL8; protein.
DR Bgee; ENSG00000035115; Expressed in nephron tubule and 208 other tissues.
DR ExpressionAtlas; Q96HL8; baseline and differential.
DR Genevisible; Q96HL8; HS.
DR GO; GO:0032587; C:ruffle membrane; IDA:MGI.
DR GO; GO:0019902; F:phosphatase binding; IDA:MGI.
DR GO; GO:0035091; F:phosphatidylinositol binding; IDA:MGI.
DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:Ensembl.
DR GO; GO:1900027; P:regulation of ruffle assembly; IEA:Ensembl.
DR CDD; cd11841; SH3_SH3YL1_like; 1.
DR CDD; cd11525; SYLF_SH3YL1_like; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035511; SH3YL1_SH3.
DR InterPro; IPR033643; SYLF_SH3YL1-like.
DR InterPro; IPR007461; Ysc84_actin-binding.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF04366; Ysc84; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Reference proteome; SH3 domain.
FT CHAIN 1..342
FT /note="SH3 domain-containing YSC84-like protein 1"
FT /id="PRO_0000341560"
FT DOMAIN 283..342
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 218..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..96
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_034332"
FT VAR_SEQ 97
FT /note="E -> M (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_034333"
FT VAR_SEQ 98..342
FT /note="VSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVALRSSAAV
FT FTYCKSRGLFAGVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILD
FT SFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNRNEYK
FT LYPGLSSYHERVGNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGK
FT LRGQTGIFPANYVTMN -> THLQLHIPSEHCPGCLP (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034334"
FT VAR_SEQ 262..280
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT /id="VSP_034335"
FT CONFLICT 4
FT /note="P -> H (in Ref. 5; AAH34974/AAH30778)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="I -> V (in Ref. 1; BAF85001)"
FT /evidence="ECO:0000305"
FT CONFLICT 141
FT /note="V -> M (in Ref. 1; BAF85001)"
FT /evidence="ECO:0000305"
FT STRAND 286..289
FT /evidence="ECO:0007829|PDB:2D8H"
FT STRAND 309..314
FT /evidence="ECO:0007829|PDB:2D8H"
FT STRAND 319..327
FT /evidence="ECO:0007829|PDB:2D8H"
FT STRAND 330..335
FT /evidence="ECO:0007829|PDB:2D8H"
FT HELIX 336..338
FT /evidence="ECO:0007829|PDB:2D8H"
SQ SEQUENCE 342 AA; 37148 MW; A12F0276A870B863 CRC64;
MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAIL SVIKAGFLVT
ARGGSGIVVA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD LVIILNYDRA VEAFAKGGNL
TLGGNLTVAV GPLGRNLEGN VALRSSAAVF TYCKSRGLFA GVSLEGSCLI ERKETNRKFY
CQDIRAYDIL FGDTPRPAQA EDLYEILDSF TEKYENEGQR INARKAAREQ RKSSAKELPP
KPLSRPQQSS APVQLNSGSQ SNRNEYKLYP GLSSYHERVG NLNQPIEVTA LYSFEGQQPG
DLNFQAGDRI TVISKTDSHF DWWEGKLRGQ TGIFPANYVT MN
