SH3Y1_MOUSE
ID SH3Y1_MOUSE Reviewed; 340 AA.
AC O08641; Q6P7V3; Q6PDR3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=SH3 domain-containing YSC84-like protein 1;
GN Name=Sh3yl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=10771491; DOI=10.1046/j.1523-1747.2000.00971.x;
RA Aoki N., Ito K., Ito M.;
RT "A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle.";
RL J. Invest. Dermatol. 114:1050-1056(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=129, and FVB/N; TISSUE=Mammary tumor, and Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH SH3D19.
RX PubMed=12615363; DOI=10.1016/s0923-1811(02)00140-8;
RA Shimomura Y., Aoki N., Ito K., Ito M.;
RT "Gene expression of Sh3d19, a novel adaptor protein with five Src homology
RT 3 domains, in anagen mouse hair follicles.";
RL J. Dermatol. Sci. 31:43-51(2003).
CC -!- SUBUNIT: Interacts with SH3D19. {ECO:0000269|PubMed:12615363}.
CC -!- INTERACTION:
CC O08641; Q91X43: Sh3d19; NbExp=3; IntAct=EBI-2024519, EBI-2024543;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=O08641-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O08641-2; Sequence=VSP_034336;
CC Name=3;
CC IsoId=O08641-3; Sequence=VSP_034337;
CC -!- TISSUE SPECIFICITY: Expressed in skin, kidney, stomach, small intestine
CC and colon. Highly expressed in the anagen hair follicle. In hair, it is
CC expressed predominantly in the hair bulb, the hair shaft, inner root
CC sheath, and outer root sheath in the lower half of the follicle.
CC {ECO:0000269|PubMed:10771491}.
CC -!- DEVELOPMENTAL STAGE: In skin, expression follows hair-growth cycle,
CC increasing significantly during mid and late anagen phases, and
CC decreases during catagen, telogen and early anagen phases.
CC {ECO:0000269|PubMed:10771491}.
CC -!- SIMILARITY: Belongs to the SH3YL1 family. {ECO:0000305}.
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DR EMBL; D85926; BAA19679.1; -; mRNA.
DR EMBL; AK141199; BAE24582.1; -; mRNA.
DR EMBL; BC010296; AAH10296.1; -; mRNA.
DR EMBL; BC058557; AAH58557.1; -; mRNA.
DR EMBL; BC061488; AAH61488.1; -; mRNA.
DR EMBL; BC110043; AAI10044.1; -; mRNA.
DR CCDS; CCDS25859.1; -. [O08641-1]
DR CCDS; CCDS79110.1; -. [O08641-2]
DR RefSeq; NP_001276409.1; NM_001289480.1. [O08641-2]
DR RefSeq; NP_038737.1; NM_013709.5. [O08641-1]
DR AlphaFoldDB; O08641; -.
DR SMR; O08641; -.
DR IntAct; O08641; 2.
DR STRING; 10090.ENSMUSP00000020997; -.
DR PhosphoSitePlus; O08641; -.
DR PaxDb; O08641; -.
DR PeptideAtlas; O08641; -.
DR PRIDE; O08641; -.
DR ProteomicsDB; 257146; -. [O08641-1]
DR ProteomicsDB; 257147; -. [O08641-2]
DR ProteomicsDB; 257148; -. [O08641-3]
DR Antibodypedia; 49866; 39 antibodies from 13 providers.
DR DNASU; 24057; -.
DR Ensembl; ENSMUST00000020997; ENSMUSP00000020997; ENSMUSG00000020669. [O08641-1]
DR Ensembl; ENSMUST00000110880; ENSMUSP00000106504; ENSMUSG00000020669. [O08641-2]
DR GeneID; 24057; -.
DR KEGG; mmu:24057; -.
DR UCSC; uc007ngz.2; mouse. [O08641-1]
DR UCSC; uc011ylg.2; mouse. [O08641-2]
DR CTD; 26751; -.
DR MGI; MGI:1346118; Sh3yl1.
DR VEuPathDB; HostDB:ENSMUSG00000020669; -.
DR eggNOG; KOG1843; Eukaryota.
DR GeneTree; ENSGT00510000048137; -.
DR HOGENOM; CLU_015320_2_1_1; -.
DR InParanoid; O08641; -.
DR OMA; NDAMYND; -.
DR OrthoDB; 1090526at2759; -.
DR PhylomeDB; O08641; -.
DR TreeFam; TF331022; -.
DR BioGRID-ORCS; 24057; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Sh3yl1; mouse.
DR PRO; PR:O08641; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; O08641; protein.
DR Bgee; ENSMUSG00000020669; Expressed in seminal vesicle and 227 other tissues.
DR Genevisible; O08641; MM.
DR GO; GO:0032587; C:ruffle membrane; ISO:MGI.
DR GO; GO:0019902; F:phosphatase binding; ISO:MGI.
DR GO; GO:0035091; F:phosphatidylinositol binding; ISO:MGI.
DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IMP:MGI.
DR GO; GO:1900027; P:regulation of ruffle assembly; IMP:MGI.
DR CDD; cd11841; SH3_SH3YL1_like; 1.
DR CDD; cd11525; SYLF_SH3YL1_like; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035511; SH3YL1_SH3.
DR InterPro; IPR033643; SYLF_SH3YL1-like.
DR InterPro; IPR007461; Ysc84_actin-binding.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF04366; Ysc84; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; SH3 domain.
FT CHAIN 1..340
FT /note="SH3 domain-containing YSC84-like protein 1"
FT /id="PRO_0000341561"
FT DOMAIN 281..340
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 226..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 38..76
FT /note="AHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGK -> E (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034336"
FT VAR_SEQ 233..340
FT /note="AKELPPKPSSRPQPAHPPVQLNAGSQGNRNEYKLYPELSSYHEKTGNLNQPI
FT EVTALYSFEGQQPGDLNFQAGDRIIVISKTDSNFDWWEGKLRGQTGIFPANYVTMN ->
FT VLWPGFTSLSVNMRGSVLAQL (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_034337"
FT CONFLICT 200
FT /note="A -> T (in Ref. 3; AAH61488)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 37028 MW; 3FE12C0A8530C74E CRC64;
MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAVL SVIKAGFLVT
ARGGSGIVLA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD LVIILNYDRA VEAFAKGGNL
TLGGNFTVAV GPLGRNLEGN VSLRSSAAVF TYCKSRGLFA GISLEGSCLI ERKETNRKFY
CQDIRAYDIL FGDVPQPAQA EDLYEILNSF TEKYETEGQR INLKKVAREQ RKAKELPPKP
SSRPQPAHPP VQLNAGSQGN RNEYKLYPEL SSYHEKTGNL NQPIEVTALY SFEGQQPGDL
NFQAGDRIIV ISKTDSNFDW WEGKLRGQTG IFPANYVTMN
