ID   SHA9A_DANRE             Reviewed;         382 AA.
AC   Q5BLC7;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein shisa-9A;
DE   Flags: Precursor;
GN   Name=shisa9a; ORFNames=zgc:113574;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of short-term neuronal synaptic plasticity in the
CC       dentate gyrus. Associates with AMPA receptors (ionotropic glutamate
CC       receptors) in synaptic spines and promotes AMPA receptor
CC       desensitization at excitatory synapses (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of some AMPA receptors (ionotropic glutamate
CC       receptors) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC       Synapse {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shisa family. SHISA9 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC090494; AAH90494.1; -; mRNA.
DR   RefSeq; NP_001013527.1; NM_001013509.1.
DR   AlphaFoldDB; Q5BLC7; -.
DR   SMR; Q5BLC7; -.
DR   STRING; 7955.ENSDARP00000066385; -.
DR   PaxDb; Q5BLC7; -.
DR   GeneID; 541382; -.
DR   KEGG; dre:541382; -.
DR   CTD; 541382; -.
DR   ZFIN; ZDB-GENE-050320-78; shisa9a.
DR   eggNOG; ENOG502QT2A; Eukaryota.
DR   InParanoid; Q5BLC7; -.
DR   OrthoDB; 659452at2759; -.
DR   PhylomeDB; Q5BLC7; -.
DR   PRO; PR:Q5BLC7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0032281; C:AMPA glutamate receptor complex; IBA:GO_Central.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0032591; C:dendritic spine membrane; ISS:UniProtKB.
DR   GO; GO:0008328; C:ionotropic glutamate receptor complex; ISS:UniProtKB.
DR   GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR   GO; GO:2000311; P:regulation of AMPA receptor activity; IBA:GO_Central.
DR   GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; ISS:UniProtKB.
DR   InterPro; IPR026910; Shisa.
DR   PANTHER; PTHR31774; PTHR31774; 1.
DR   Pfam; PF13908; Shisa; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Glycoprotein; Membrane;
KW   Postsynaptic cell membrane; Reference proteome; Signal; Synapse;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..382
FT                   /note="Protein shisa-9A"
FT                   /id="PRO_0000394255"
FT   TOPO_DOM        27..132
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        154..382
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   382 AA;  42971 MW;  5731666811E00D05 CRC64;
     MKWTVLLLEY FLVKVLVLLY SADGEAQQLE GFIMLSGSNG SRDEESVSEP PHTEDKCRGY
     YDVMGQWDPP FVCQTGNYLY CCGTCGFRFC CAYKNSRLDQ STCKNYDTPV WLTGQTPYKK
     TLDPRHDPTK DKTNLIVYII CGVVAIMALV GIFTKLGLEK AHRPHRESMS RAVASVMQGA
     RQGQHEEAIG MHTQHYDTVQ ARANNMQAGQ INNMMQTHPY PALSQLSHVY EQQQSAKDLN
     KYASLKAVAA KANGDFLNKQ HRHLVELAAK GNLPLHPIRM EHVEPTATYV TEVPCIKQNG
     QKPKSIKANV SHPAMAYSSN TIANPGMLRS WEAAETAGRR KTYNPRKMCM VEQVNELHTA
     RSHHYLPTQP YFVTNSKAEV TV