SHAKB_AEDAE
ID SHAKB_AEDAE Reviewed; 372 AA.
AC Q1DH70;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Innexin shaking-B;
GN Name=shakB {ECO:0000250|UniProtKB:P33085}; ORFNames=AAEL014227;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000312|EMBL:EAT32503.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Structural component of the gap junctions at electrical
CC synapses in distal and mid-depth levels in the lamina.
CC {ECO:0000250|UniProtKB:P33085}.
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:P33085}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC junction {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00351}.
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DR EMBL; CH899795; EAT32503.1; -; Genomic_DNA.
DR RefSeq; XP_001647835.1; XM_001647785.1.
DR AlphaFoldDB; Q1DH70; -.
DR SMR; Q1DH70; -.
DR STRING; 7159.AAEL014227-PA; -.
DR GeneID; 5579528; -.
DR KEGG; aag:5579528; -.
DR VEuPathDB; VectorBase:AAEL014227; -.
DR eggNOG; ENOG502QWRS; Eukaryota.
DR HOGENOM; CLU_035763_1_1_1; -.
DR InParanoid; Q1DH70; -.
DR OMA; TSYTFWG; -.
DR OrthoDB; 738314at2759; -.
DR PhylomeDB; Q1DH70; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0005921; C:gap junction; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR GO; GO:0009881; F:photoreceptor activity; ISS:UniProtKB.
DR GO; GO:0016264; P:gap junction assembly; ISS:UniProtKB.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0009416; P:response to light stimulus; ISS:UniProtKB.
DR InterPro; IPR000990; Innexin.
DR PANTHER; PTHR11893; PTHR11893; 1.
DR Pfam; PF00876; Innexin; 1.
DR PRINTS; PR01262; INNEXIN.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 3: Inferred from homology;
KW Cell junction; Cell membrane; Gap junction; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..372
FT /note="Innexin shaking-B"
FT /id="PRO_0000307709"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 43..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 127..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 204..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 289..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 372 AA; 44510 MW; DEFBEE45D1FF9F78 CRC64;
MLDIFRGLKN LVKISHVNTD SPVFRLHYSI TVMILMAFSL IVTTKQYVGN PIDCVHTKDI
PEEVLNTYCW IHSTYALKSL FLKKVGSEVP YPGVGNSDGK NIDKKIYKYY QWVCFCLFFQ
AILFYTPRWL WKSWEGGKIH ALMMDLDIGI CSEIEKKQKK KLLLDYLWDN LRYHNWWAYR
YYICEFLSLV NVIGQMFLMN RFFDGEFMTF GLDVITHMEA DQEDRMDPMI YIFPRMTKCT
FYKYGVSGEV ERHDAICILP LNVVNEKIYI FLWFWFIILT ILTTLTIFYR IIIIFSPRMR
VYLLRLRFRL VRRDAIEIIV RRSKMGDWFL LYRLGENLDS IIFRDVMQDL ANRLHNNQHH
RVPGMKGEIQ DA
