SHAKB_ANOGA
ID SHAKB_ANOGA Reviewed; 373 AA.
AC Q7PXN1;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Innexin shaking-B;
GN Name=shakB {ECO:0000250|UniProtKB:P33085}; ORFNames=AGAP001487;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1] {ECO:0000312|EMBL:EAA00824.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000312|EMBL:EAA00824.1};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Structural component of the gap junctions at electrical
CC synapses in distal and mid-depth levels in the lamina.
CC {ECO:0000250|UniProtKB:P33085}.
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:P33085}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC junction {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00351}.
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DR EMBL; AAAB01008987; EAA00824.1; -; Genomic_DNA.
DR RefSeq; XP_321635.1; XM_321635.2.
DR AlphaFoldDB; Q7PXN1; -.
DR SMR; Q7PXN1; -.
DR STRING; 7165.AGAP001487-PA; -.
DR PaxDb; Q7PXN1; -.
DR GeneID; 4577242; -.
DR KEGG; aga:AgaP_AGAP001487; -.
DR CTD; 4577242; -.
DR VEuPathDB; VectorBase:AGAP001487; -.
DR eggNOG; ENOG502QWRS; Eukaryota.
DR HOGENOM; CLU_035763_1_1_1; -.
DR InParanoid; Q7PXN1; -.
DR OMA; TSYTFWG; -.
DR OrthoDB; 738314at2759; -.
DR PhylomeDB; Q7PXN1; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0005921; C:gap junction; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR GO; GO:0009881; F:photoreceptor activity; ISS:UniProtKB.
DR GO; GO:0016264; P:gap junction assembly; ISS:UniProtKB.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0009416; P:response to light stimulus; ISS:UniProtKB.
DR InterPro; IPR000990; Innexin.
DR PANTHER; PTHR11893; PTHR11893; 1.
DR Pfam; PF00876; Innexin; 1.
DR PRINTS; PR01262; INNEXIN.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 3: Inferred from homology;
KW Cell junction; Cell membrane; Gap junction; Ion channel; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..373
FT /note="Innexin shaking-B"
FT /id="PRO_0000307710"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 43..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 128..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..199
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 200..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 290..373
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 373 AA; 44426 MW; 789FAE1001747528 CRC64;
MLDIFRGLKS LVKISHVNTD SPVFRLHYSI TVIILMSFSL IVTTRQYVGN PIDCVHTKDI
PADVLNTYCW IHSTFALKSL FLKEVGKDVP YPGVGNSAEA TAADKKIYKY YQWVCFCLFF
QAILFYTPRW LWKSWEGGKI HALMMDLDIG ICSEIEKKQK KKLLLDYLWD NLRYHNWWAY
RYYVCEFLSL CNVIGQMFLM NRFFDGEFMT FGLDVITHME ADQEDRMDPM IYIFPRMTKC
TFYKYGVSGE VERHDAICIL PLNVVNEKIY IFLWFWFIIL TILTTLTIFY RIIIIFSPRM
RVYLLRLRFR LVRRDAIEII VRRSKMGDWF LLYRLGENLD SIIFRDVMQD LANRLHNNQH
HRVPGMKGEI QDA
