SHA_ARATH
ID SHA_ARATH Reviewed; 641 AA.
AC B5X561; A0A1P8AQE5; F4I632; Q9SHG3;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=SH2 domain-containing protein A {ECO:0000303|PubMed:15063865};
DE Short=AtSHA {ECO:0000303|PubMed:15063865};
DE AltName: Full=STAT-type linker-SH2 domain factor A {ECO:0000303|PubMed:15073273};
GN Name=SHA {ECO:0000303|PubMed:15063865};
GN Synonyms=STATLA {ECO:0000303|PubMed:15073273};
GN OrderedLocusNames=At1g17040 {ECO:0000312|Araport:AT1G17040};
GN ORFNames=F20D23.26 {ECO:0000312|EMBL:AAD50031.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA de los Reyes C., Quan R., Chen H., Bautista V., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, AND PHOSPHORYLATION AT TYROSINE RESIDUES.
RC STRAIN=cv. Columbia;
RX PubMed=15073273; DOI=10.1074/mcp.m300131-mcp200;
RA Gao Q., Hua J., Kimura R., Headd J.J., Fu X.-Y., Chin Y.E.;
RT "Identification of the linker-SH2 domain of STAT as the origin of the SH2
RT domain using two-dimensional structural alignment.";
RL Mol. Cell. Proteomics 3:704-714(2004).
RN [5]
RP GENE FAMILY.
RX PubMed=15063865; DOI=10.1016/j.tplants.2004.02.001;
RA Williams J.G., Zvelebil M.;
RT "SH2 domains in plants imply new signalling scenarios.";
RL Trends Plant Sci. 9:161-163(2004).
RN [6]
RP GENE FAMILY.
RX PubMed=18701541; DOI=10.1242/dev.026377;
RA Yamada Y., Wang H.Y., Fukuzawa M., Barton G.J., Williams J.G.;
RT "A new family of transcription factors.";
RL Development 135:3093-3101(2008).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=B5X561-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B5X561-2; Sequence=VSP_059035;
CC Name=3;
CC IsoId=B5X561-3; Sequence=VSP_059036, VSP_059037;
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC {ECO:0000269|PubMed:15073273}.
CC -!- PTM: Phosphorylated on tyrosine residues.
CC {ECO:0000269|PubMed:15073273}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD50031.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007651; AAD50031.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29533.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29534.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58869.1; -; Genomic_DNA.
DR EMBL; BT046180; ACI49779.1; -; mRNA.
DR PIR; B86306; B86306.
DR RefSeq; NP_001185018.1; NM_001198089.1. [B5X561-2]
DR RefSeq; NP_001321275.1; NM_001332274.1. [B5X561-3]
DR RefSeq; NP_173147.2; NM_101564.4. [B5X561-1]
DR AlphaFoldDB; B5X561; -.
DR STRING; 3702.AT1G17040.2; -.
DR PRIDE; B5X561; -.
DR ProteomicsDB; 234558; -. [B5X561-1]
DR EnsemblPlants; AT1G17040.1; AT1G17040.1; AT1G17040. [B5X561-1]
DR EnsemblPlants; AT1G17040.2; AT1G17040.2; AT1G17040. [B5X561-2]
DR EnsemblPlants; AT1G17040.3; AT1G17040.3; AT1G17040. [B5X561-3]
DR GeneID; 838274; -.
DR Gramene; AT1G17040.1; AT1G17040.1; AT1G17040. [B5X561-1]
DR Gramene; AT1G17040.2; AT1G17040.2; AT1G17040. [B5X561-2]
DR Gramene; AT1G17040.3; AT1G17040.3; AT1G17040. [B5X561-3]
DR KEGG; ath:AT1G17040; -.
DR Araport; AT1G17040; -.
DR TAIR; locus:2020377; AT1G17040.
DR eggNOG; ENOG502QRR2; Eukaryota.
DR HOGENOM; CLU_014741_0_0_1; -.
DR OMA; WVHIGCE; -.
DR OrthoDB; 401999at2759; -.
DR PhylomeDB; B5X561; -.
DR PRO; PR:B5X561; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; B5X561; baseline and differential.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR PANTHER; PTHR11801; PTHR11801; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; SH2 domain.
FT CHAIN 1..641
FT /note="SH2 domain-containing protein A"
FT /id="PRO_0000441175"
FT DOMAIN 547..641
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 355..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 53
FT /note="Q -> QINLFCELGEK (in isoform 2)"
FT /id="VSP_059035"
FT VAR_SEQ 610
FT /note="D -> E (in isoform 3)"
FT /id="VSP_059036"
FT VAR_SEQ 611..641
FT /note="Missing (in isoform 3)"
FT /id="VSP_059037"
SQ SEQUENCE 641 AA; 72636 MW; 5CBEAE9B8455D21D CRC64;
MAGDCAIDTE KYSLLEDFNV DVEVENKAFE TFSLCFWVYL LDSTTYPSAI IRQVHSDMSV
SAPFLVLDEN KKMMLLPLTL LHREAPDPVN TSSWTEVPNV STTAKFPLQK WVHVGCEVSR
NYMRLYICGE LVGEQVLTSL MTNGTNSDCA RKISLFSVGG DGYSVQGFIH SAEVLPSNLS
ASYHYTKDPP LWLSVDKPST SGIELDEDGV WSVVSGTFCS LDVVLTNAIG QPVHKDVKVV
ASLLYADSGT HVEKRSDFEA FLLVSYEGIE LSAEDKPCNL LNGCASFKFK LSQLSSKSDK
RLFCIKFEIP EVKANYPFLE TVTNQIRCIS RNRDSVSSMK RIRLGEEKVS ESKIVNGNGT
SMEWRPQNHE EDNSSTDSEN TEMRDSTAFR RYSIPDWIIF KYCLGNLTER ALLLKEITNN
SSDEEVSEFA DQVSLYSGCS HHGYQIKMAR KLIAEGTNAW NLISRNYRHV HWDNVVIEIE
EHFMRIAKCS SRSLTHQDFD LLRRICGCYE YITQENFETM WCWLFPVASA VSRGLINGMW
RSASPKWIEG FVTKEEAERS LQNQVPGTFI LRFPTSRSWP HPDAGSVVVT YVGHDLVIHH
RLLTINHICD SSERYTDAKQ LQDMLLAEPE LSRLGRIIRG I
