SHB_ARATH
ID SHB_ARATH Reviewed; 668 AA.
AC Q56XZ1; A0A1P8ATT7; F4IA94; Q9SYM8;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=SH2 domain-containing protein B {ECO:0000303|PubMed:15063865};
DE Short=AtSHB {ECO:0000303|PubMed:15063865};
DE AltName: Full=STAT-type linker-SH2 domain factor B {ECO:0000303|PubMed:15073273};
GN Name=SHB {ECO:0000303|PubMed:15063865};
GN Synonyms=STATLB {ECO:0000303|PubMed:15073273};
GN OrderedLocusNames=At1g78540 {ECO:0000312|Araport:AT1G78540};
GN ORFNames=T30F21.13 {ECO:0000312|EMBL:AAD30582.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, AND PHOSPHORYLATION AT TYROSINE RESIDUES.
RC STRAIN=cv. Columbia;
RX PubMed=15073273; DOI=10.1074/mcp.m300131-mcp200;
RA Gao Q., Hua J., Kimura R., Headd J.J., Fu X.-Y., Chin Y.E.;
RT "Identification of the linker-SH2 domain of STAT as the origin of the SH2
RT domain using two-dimensional structural alignment.";
RL Mol. Cell. Proteomics 3:704-714(2004).
RN [5]
RP GENE FAMILY.
RX PubMed=15063865; DOI=10.1016/j.tplants.2004.02.001;
RA Williams J.G., Zvelebil M.;
RT "SH2 domains in plants imply new signalling scenarios.";
RL Trends Plant Sci. 9:161-163(2004).
RN [6]
RP GENE FAMILY.
RX PubMed=18701541; DOI=10.1242/dev.026377;
RA Yamada Y., Wang H.Y., Fukuzawa M., Barton G.J., Williams J.G.;
RT "A new family of transcription factors.";
RL Development 135:3093-3101(2008).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q56XZ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q56XZ1-2; Sequence=VSP_059039;
CC Name=3;
CC IsoId=Q56XZ1-3; Sequence=VSP_059038;
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC {ECO:0000269|PubMed:15073273}.
CC -!- PTM: Phosphorylated on tyrosine residues.
CC {ECO:0000269|PubMed:15073273}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD30582.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007260; AAD30582.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE36118.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE36119.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60040.1; -; Genomic_DNA.
DR EMBL; AK221532; BAD94855.1; -; mRNA.
DR PIR; H96813; H96813.
DR RefSeq; NP_001185427.1; NM_001198498.1. [Q56XZ1-2]
DR RefSeq; NP_001322353.1; NM_001334830.1. [Q56XZ1-3]
DR RefSeq; NP_177975.3; NM_106501.5. [Q56XZ1-1]
DR AlphaFoldDB; Q56XZ1; -.
DR STRING; 3702.AT1G78540.2; -.
DR PRIDE; Q56XZ1; -.
DR ProteomicsDB; 234575; -. [Q56XZ1-1]
DR EnsemblPlants; AT1G78540.1; AT1G78540.1; AT1G78540. [Q56XZ1-1]
DR EnsemblPlants; AT1G78540.2; AT1G78540.2; AT1G78540. [Q56XZ1-2]
DR EnsemblPlants; AT1G78540.3; AT1G78540.3; AT1G78540. [Q56XZ1-3]
DR GeneID; 844190; -.
DR Gramene; AT1G78540.1; AT1G78540.1; AT1G78540. [Q56XZ1-1]
DR Gramene; AT1G78540.2; AT1G78540.2; AT1G78540. [Q56XZ1-2]
DR Gramene; AT1G78540.3; AT1G78540.3; AT1G78540. [Q56XZ1-3]
DR KEGG; ath:AT1G78540; -.
DR Araport; AT1G78540; -.
DR TAIR; locus:2202995; AT1G78540.
DR eggNOG; ENOG502QRR2; Eukaryota.
DR HOGENOM; CLU_014741_0_0_1; -.
DR OMA; HRINAMW; -.
DR OrthoDB; 401999at2759; -.
DR PhylomeDB; Q56XZ1; -.
DR PRO; PR:Q56XZ1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q56XZ1; baseline and differential.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR PANTHER; PTHR11801; PTHR11801; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; SH2 domain.
FT CHAIN 1..668
FT /note="SH2 domain-containing protein B"
FT /id="PRO_0000441176"
FT DOMAIN 574..642
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 373..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 638..668
FT /note="Missing (in isoform 3)"
FT /id="VSP_059038"
FT VAR_SEQ 664..668
FT /note="IKRSH -> NVVLLWIFVCAGSKEATECYAFSNIQTLNLSYS (in
FT isoform 2)"
FT /id="VSP_059039"
SQ SEQUENCE 668 AA; 75812 MW; BA29E117ABCEEB7B CRC64;
MASAATIETE KYSLLEDFNV DVEVDDEEYE SFSLCFWVYL LNSTTFPSTI IRQVHSDMSV
SAPFLVLDEN KKMMLLPLTL LHKEAPDPVD TSSWTQVPSV STKSKFPLEK WVHVGCEVSR
NFMRLFIDGN MEGEQFVTSL LTKNAYPECP RKISLFSVGG DGYSVQGFIQ CAEVLPASDH
VEHHYMKDPP LMLSVNKSSS SGIKLDDCGV WQASCKEMFS LDVLLSNAIG QPVHKDVEVV
ASLLYADTLP EAKMGEAEAP LLIRDEGVQF SSDDRPIKLL NGRSSFKLKI SQLSSNSDDR
LFWIKFGIRN AKDYPFLQAV SNPIRCISVS PEVQPVSVTP KRLTNIDHLS STESPDLLQN
TSSVKRIRLG KESVSGSEES YQQCNSHPQT SRQFENGNGM RLHEEDNSSI DSENSEMRYT
ISDSTIFKYC LGNLIDKALL LKEITNNSSD DEVLEFANQV SLYSGCSHHS YQINMARELI
AEGTNAWILI SRNNQHVHWD NVVYEIEEHF MRISKCSSRS LTHQDFELLR RISGCYEYIT
QENFEKMWCW LFPVAYSISR GLINGMWRSS SPKWIEGFIT KEEAEHSLQG QEPGTFILRF
PISRTWPHPD AGSLVVTYVG HDFALHHKQL KIDNICESSE RYMDAKPLQD MLLAEPELSR
LGRIKRSH
