SHC1_YEAST
ID SHC1_YEAST Reviewed; 512 AA.
AC P39000; D3DM04;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Protein SHC1;
DE AltName: Full=Sporulation-specific homolog of CSD4;
GN Name=SHC1; OrderedLocusNames=YER096W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-454.
RX PubMed=1581961; DOI=10.1016/0092-8674(92)90447-k;
RA Shinohara A., Ogawa H., Ogawa T.;
RT "Rad51 protein involved in repair and recombination in S. cerevisiae is a
RT RecA-like protein.";
RL Cell 69:457-470(1992).
RN [4]
RP INDUCTION.
RX PubMed=10082665; DOI=10.1006/bbrc.1999.0158;
RA Hong S.K., Han S.B., Snyder M., Choi E.Y.;
RT "SHC1, a high pH inducible gene required for growth at alkaline pH in
RT Saccharomyces cerevisiae.";
RL Biochem. Biophys. Res. Commun. 255:116-122(1999).
RN [5]
RP INDUCTION, AND FUNCTION.
RX PubMed=11918806; DOI=10.1046/j.1365-2958.2002.02812.x;
RA Sanz M., Trilla J.A., Duran A., Roncero C.;
RT "Control of chitin synthesis through Shc1p, a functional homologue of Chs4p
RT specifically induced during sporulation.";
RL Mol. Microbiol. 43:1183-1195(2002).
RN [6]
RP FUNCTION.
RX PubMed=15715908; DOI=10.1186/1471-2156-6-8;
RA Lesage G., Shapiro J., Specht C.A., Sdicu A.-M., Menard P., Hussein S.,
RA Tong A.H.Y., Boone C., Bussey H.;
RT "An interactional network of genes involved in chitin synthesis in
RT Saccharomyces cerevisiae.";
RL BMC Genet. 6:8-8(2005).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=15755916; DOI=10.1128/ec.4.3.536-544.2005;
RA Iwamoto M.A., Fairclough S.R., Rudge S.A., Engebrecht J.;
RT "Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required
RT for spore wall synthesis.";
RL Eukaryot. Cell 4:536-544(2005).
CC -!- FUNCTION: Required for the activation of chitin synthase III (CHS3)
CC activity during the sporulation process. {ECO:0000269|PubMed:11918806,
CC ECO:0000269|PubMed:15715908}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15755916}.
CC Cytoplasmic granule membrane {ECO:0000269|PubMed:15755916}; Peripheral
CC membrane protein {ECO:0000269|PubMed:15755916}.
CC -!- INDUCTION: During sporulation and at high pH.
CC {ECO:0000269|PubMed:10082665, ECO:0000269|PubMed:11918806}.
CC -!- SIMILARITY: Belongs to the SKT5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA20966.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U18839; AAB64651.1; -; Genomic_DNA.
DR EMBL; D10023; BAA20966.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BK006939; DAA07758.1; -; Genomic_DNA.
DR PIR; S50599; S50599.
DR RefSeq; NP_011022.1; NM_001178987.1.
DR AlphaFoldDB; P39000; -.
DR SMR; P39000; -.
DR BioGRID; 36842; 43.
DR DIP; DIP-5778N; -.
DR STRING; 4932.YER096W; -.
DR PaxDb; P39000; -.
DR PRIDE; P39000; -.
DR EnsemblFungi; YER096W_mRNA; YER096W; YER096W.
DR GeneID; 856832; -.
DR KEGG; sce:YER096W; -.
DR SGD; S000000898; SHC1.
DR VEuPathDB; FungiDB:YER096W; -.
DR eggNOG; KOG1550; Eukaryota.
DR GeneTree; ENSGT00940000176440; -.
DR HOGENOM; CLU_532327_0_0_1; -.
DR InParanoid; P39000; -.
DR OMA; TAICYEC; -.
DR BioCyc; YEAST:G3O-30263-MON; -.
DR PRO; PR:P39000; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P39000; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005628; C:prospore membrane; IDA:SGD.
DR GO; GO:0008047; F:enzyme activator activity; IGI:SGD.
DR GO; GO:0030437; P:ascospore formation; IDA:SGD.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0006031; P:chitin biosynthetic process; IGI:SGD.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF08238; Sel1; 4.
DR SMART; SM00671; SEL1; 4.
PE 2: Evidence at transcript level;
KW Cell wall biogenesis/degradation; Cytoplasm; Membrane; Reference proteome;
KW Repeat; Sporulation.
FT CHAIN 1..512
FT /note="Protein SHC1"
FT /id="PRO_0000202642"
FT REPEAT 318..353
FT /note="Sel1-like 1"
FT REPEAT 354..389
FT /note="Sel1-like 2"
FT REPEAT 390..429
FT /note="Sel1-like 3"
FT REPEAT 433..470
FT /note="Sel1-like 4"
FT REGION 101..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 22
FT /note="V -> G (in Ref. 3; BAA20966)"
FT /evidence="ECO:0000305"
FT CONFLICT 33
FT /note="S -> P (in Ref. 3; BAA20966)"
FT /evidence="ECO:0000305"
FT CONFLICT 90
FT /note="Y -> I (in Ref. 3; BAA20966)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="L -> S (in Ref. 3; BAA20966)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="K -> E (in Ref. 3; BAA20966)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="K -> R (in Ref. 3; BAA20966)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 512 AA; 56578 MW; 654D742482616658 CRC64;
MSMTICSNTP GAYPEIGAYN EVDKQLESSG FSSDSSLILN KPEVRQYWSS VSSHISRSGD
VFTNDKEKIS SSIGEDAMDI DASPSLIEKY NSFPTRKILP EQDEFENDVE DDASSSLKEK
SQGSCEIEIA SEISSEILNG TSADGNSEFH DFAEPPPSQN ESVALSFSQS NDLDFLNNPS
GSGSSNDINR STSSISLPRH VSLDFNVYNS LCLTNEVTAS ESHNVAKFHL GKKNKKSLLP
RWKTIEMYGE VVKKTQDIYS NFQYAQYILR VGLDTEKLHE LVKELEDESN SFSVDSLKEY
LVNDAKVILK KLSAVGYPDA QYLLGDAYSS GVFGKIKNRR AFLLFSAAAK RMHIESVYRT
AICYECGLGV TRNAPKAVNF LTFAATKNHP AAMYKLGVYS YHGLMGLPDD ILTKMDGYRW
LRRATSMASS FVCGAPFELA NIYMTGYKDL IISDPDYAMA LYEKAAALGH TESARILEDA
RRSGGFVSRG HPPSAQKYHK TSHEAVAAKK LI
