ID   BGLS_BUTFI              Reviewed;         830 AA.
AC   P16084;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Beta-glucosidase A;
DE            EC=3.2.1.21;
DE   AltName: Full=Beta-D-glucoside glucohydrolase;
DE   AltName: Full=Cellobiase;
DE   AltName: Full=Gentiobiase;
GN   Name=bglA;
OS   Butyrivibrio fibrisolvens.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Butyrivibrio.
OX   NCBI_TaxID=831;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=H17C;
RX   PubMed=2262790; DOI=10.1099/00221287-136-8-1567;
RA   Lin L.L., Rumbak E., Zappe H., Thompson J.A., Woods D.R.;
RT   "Cloning, sequencing and analysis of expression of a Butyrivibrio
RT   fibrisolvens gene encoding a beta-glucosidase.";
RL   J. Gen. Microbiol. 136:1567-1576(1990).
CC   -!- FUNCTION: B.fibrisolvens beta-glucosidase hydrolyzes cellobiose to a
CC       limited extent, cellotriose to cellobiose and glucose, and
CC       cellotetraose and cellopentaose to predominantly glucose.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing beta-D-glucosyl residues
CC         with release of beta-D-glucose.; EC=3.2.1.21;
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family. {ECO:0000305}.
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DR   EMBL; M31120; AAA23008.1; -; Genomic_DNA.
DR   PIR; A44768; A44768.
DR   AlphaFoldDB; P16084; -.
DR   SMR; P16084; -.
DR   CAZy; GH3; Glycoside Hydrolase Family 3.
DR   GO; GO:0008422; F:beta-glucosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102483; F:scopolin beta-glucosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.20.20.300; -; 1.
DR   Gene3D; 3.40.50.1700; -; 1.
DR   InterPro; IPR026891; Fn3-like.
DR   InterPro; IPR019800; Glyco_hydro_3_AS.
DR   InterPro; IPR002772; Glyco_hydro_3_C.
DR   InterPro; IPR036881; Glyco_hydro_3_C_sf.
DR   InterPro; IPR001764; Glyco_hydro_3_N.
DR   InterPro; IPR036962; Glyco_hydro_3_N_sf.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF14310; Fn3-like; 1.
DR   Pfam; PF00933; Glyco_hydro_3; 1.
DR   Pfam; PF01915; Glyco_hydro_3_C; 1.
DR   PRINTS; PR00133; GLHYDRLASE3.
DR   SMART; SM01217; Fn3_like; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   SUPFAM; SSF52279; SSF52279; 1.
DR   PROSITE; PS00775; GLYCOSYL_HYDROL_F3; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cellulose degradation; Glycosidase; Hydrolase;
KW   Polysaccharide degradation.
FT   CHAIN           1..830
FT                   /note="Beta-glucosidase A"
FT                   /id="PRO_0000210777"
FT   ACT_SITE        769
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   830 AA;  91852 MW;  1DBF578DCA18B6F3 CRC64;
     MEKWARIKYT PNLPLGENGE RVTASQKHIE LSCEAACEGM VLLKNDRNVL PIRKGTRVAL
     FGKGVFDYVK GGGGSGDVTV PYIRNLYEGL SQYTSDISIY DKSVRFYQEY VADQYRLGIA
     PGMIKEPALP EDILADAAAY ADTAIIAISR FSGEGWDRKV AGVDREIKCE AKDLVEQGNK
     IFDHGDFYLT NAEKKMVKMV KENFSSVIVV MNVGGVVDTT WFKKDDQISS VLMAWQGGIE
     GGLAAARILL GKVNPSGKLS DTFAARLEDY PSTEGFHEDD DYVDYTEDIY VGYRYFETIP
     GAKEKVNYPF GYGLSYTTFL LEDYKAEPFV ASAADEVGKS DSDLADAIVA SVTVTNIGKI
     PGKEVVQLYY SAPQGKLGKP AKVLGGYAKT RLLQPGESQR VTIALYMEDM ASYDDLGKVK
     KAAWLLEKGE YHFFLGTSVR DTRLLDYTYE LSKNIIVEQV SNKLVPTSLP KRMLADGTYE
     ELPQTEPVDT YATIFPRPKN WKETIEHDVL KTPVVRPQDR FQLFLPPKEG DPKKFIEVAE
     CKVTLEDFIA QLSNEQLASL LGGQPNVGMA NTFGYGNLPE VGVPNAQTCD GPAGVRIAPE
     VGVVTTAFPC STLLACTWNE DICYEVGVAG GEEAKECNFG AWLTPAVNIH RSPLCGRNFE
     YYSEDPFLAG KQAAAMVRGI QSNNIIATPK HFALNNKESN RKGSDSRASE RAIREIYLKA
     FEIIVKEQSP GASCLQYNIV NGQRSSESHD LLTGILRDEW GFEGVVVSDW WGFGEHYKEV
     LAGNDIKMGC GYTEQLLEAI DKKALKRKDL EKRQSESSRC FSNSTKLKAA