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SHC3_RAT
ID   SHC3_RAT                Reviewed;         594 AA.
AC   O70143;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=SHC-transforming protein 3;
DE   AltName: Full=Neuronal Shc;
DE            Short=N-Shc;
DE   AltName: Full=SHC-transforming protein C;
DE   AltName: Full=Src homology 2 domain-containing-transforming protein C3;
DE            Short=SH2 domain protein C3;
GN   Name=Shc3; Synonyms=Nshc, Shcc;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P52 AND P66), AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=9507002; DOI=10.1074/jbc.273.12.6960;
RA   Nakamura T., Muraoka S., Sanokawa R., Mori N.;
RT   "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their
RT   differential regional expression in the brain and roles in neurotrophin and
RT   Src signaling.";
RL   J. Biol. Chem. 273:6960-6967(1998).
CC   -!- FUNCTION: Signaling adapter that couples activated growth factor
CC       receptors to signaling pathway in neurons. Involved in the signal
CC       transduction pathways of neurotrophin-activated Trk receptors in
CC       cortical neurons (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the Trk receptors in a phosphotyrosine-
CC       dependent manner. Once activated, binds to GRB2. Interacts with
CC       activated EGF receptors (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=p66;
CC         IsoId=O70143-1; Sequence=Displayed;
CC       Name=p52;
CC         IsoId=O70143-2; Sequence=VSP_018793;
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in the adult brain, in the
CC       hippocampus. {ECO:0000269|PubMed:9507002}.
CC   -!- PTM: Tyrosine phosphorylated. {ECO:0000250}.
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DR   EMBL; AB001453; BAA28174.1; -; mRNA.
DR   EMBL; AB001453; BAA28175.1; -; mRNA.
DR   AlphaFoldDB; O70143; -.
DR   SMR; O70143; -.
DR   IntAct; O70143; 2.
DR   MINT; O70143; -.
DR   STRING; 10116.ENSRNOP00000019442; -.
DR   iPTMnet; O70143; -.
DR   PhosphoSitePlus; O70143; -.
DR   PaxDb; O70143; -.
DR   PRIDE; O70143; -.
DR   RGD; 69348; Shc3.
DR   eggNOG; KOG3697; Eukaryota.
DR   InParanoid; O70143; -.
DR   PhylomeDB; O70143; -.
DR   Reactome; R-RNO-167044; Signalling to RAS.
DR   Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-RNO-8853659; RET signaling.
DR   PRO; PR:O70143; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; ISO:RGD.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; TAS:Reactome.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IBA:GO_Central.
DR   GO; GO:0005102; F:signaling receptor binding; TAS:RGD.
DR   GO; GO:0007417; P:central nervous system development; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; TAS:RGD.
DR   GO; GO:0007611; P:learning or memory; ISO:RGD.
DR   GO; GO:0035249; P:synaptic transmission, glutamatergic; ISO:RGD.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   CDD; cd01209; PTB_Shc; 1.
DR   CDD; cd09925; SH2_SHC; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006019; PID_Shc-like.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR029593; Shc3/ShcC/N-Shc.
DR   InterPro; IPR035676; SHC_SH2.
DR   PANTHER; PTHR10337:SF4; PTHR10337:SF4; 1.
DR   Pfam; PF00640; PID; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00629; SHCPIDOMAIN.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS01179; PID; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   Alternative initiation; Phosphoprotein; Reference proteome; SH2 domain.
FT   CHAIN           1..594
FT                   /note="SHC-transforming protein 3"
FT                   /id="PRO_0000022342"
FT   DOMAIN          149..334
FT                   /note="PID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT   DOMAIN          499..590
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          95..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          335..498
FT                   /note="CH1"
FT   REGION          428..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..446
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         402
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q61120"
FT   VAR_SEQ         1..120
FT                   /note="Missing (in isoform p52)"
FT                   /evidence="ECO:0000303|PubMed:9507002"
FT                   /id="VSP_018793"
SQ   SEQUENCE   594 AA;  64100 MW;  6AC6531CA30DA514 CRC64;
     MLPRTKYNRF RNDSVTSVDD LLHSLSVSGS GGKVSAEPAA SPYLVSGEAL RKAPDDGPGS
     LGHLLHKVSH LKLSSSGLRG LSSAARERAG ARLSGSCSAP SLAAPDGGSA TPGSRAPAAS
     MSATRKSRAS DEPLPRPPRG APHASDQVLG SGVTYVVKYL GCIEVLRSMR SLDFSTRTQV
     TREAISRVCE AVPGAKGAFK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD
     SKQIISNHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA
     FELRFKQYLQ CPSKIPALQD RMQSLDEPWT EEEGDGPDHP YYNSVPNKMP PPGGFLDARL
     KARPHAPDAA QFSGKEQTYY QGRHLGDAFG EDWQRAPTRQ GSLDIYSTPE GKAHMVPVGE
     TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPVLS KAASVECISP
     VTPRAPDAKM LEELNAEPWY QGEMSRKEAE ALLQEDGDFL VRKSTTNPGS FVLTGMHNGQ
     AKHLLLVDPE GTVRTKDRVF DSISHLITYH LESSLPIVSA GSELCLRQPV ERKP
 
 
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