SHCAF_CHICK
ID SHCAF_CHICK Reviewed; 222 AA.
AC Q5ZJV7;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=SIN3-HDAC complex-associated factor;
DE AltName: Full=Protein FAM60A;
DE AltName: Full=Tera protein homolog;
GN Name=SINHCAF; Synonyms=FAM60A; ORFNames=RCJMB04_15g2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this
CC subunit is important for the repression of genes encoding components of
CC the TGF-beta signaling pathway. Core component of a SIN3A complex
CC (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and
CC TET1) present in embryonic stem (ES) cells and is essential to maintain
CC the complex on chromatin. {ECO:0000250|UniProtKB:Q8C8M1,
CC ECO:0000250|UniProtKB:Q9NP50}.
CC -!- SUBUNIT: Component of the Sin3/HDAC corepressor complex at least
CC composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L, HDAC1. Found in a
CC complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT
CC and TET1. {ECO:0000250|UniProtKB:Q8C8M1, ECO:0000250|UniProtKB:Q9NP50}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8C8M1}.
CC -!- SIMILARITY: Belongs to the SINHCAF family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ720327; CAG31986.1; -; mRNA.
DR RefSeq; NP_001025937.1; NM_001030766.1.
DR AlphaFoldDB; Q5ZJV7; -.
DR STRING; 9031.ENSGALP00000021084; -.
DR PaxDb; Q5ZJV7; -.
DR GeneID; 418140; -.
DR KEGG; gga:418140; -.
DR CTD; 418140; -.
DR VEuPathDB; HostDB:geneid_418140; -.
DR eggNOG; ENOG502QSAG; Eukaryota.
DR InParanoid; Q5ZJV7; -.
DR OrthoDB; 1330424at2759; -.
DR PhylomeDB; Q5ZJV7; -.
DR PRO; PR:Q5ZJV7; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0016580; C:Sin3 complex; ISS:UniProtKB.
DR GO; GO:0045596; P:negative regulation of cell differentiation; ISS:UniProtKB.
DR GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR InterPro; IPR026065; FAM60A.
DR PANTHER; PTHR13422; PTHR13422; 1.
DR Pfam; PF15396; FAM60A; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..222
FT /note="SIN3-HDAC complex-associated factor"
FT /id="PRO_0000187089"
FT REGION 111..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 222 AA; 24968 MW; 13D029E2001B4534 CRC64;
MFGFRKPKMY RSIEGCCICR AKSSSSRFTD SKRYEKDFQN CFGLHEARSG DICNACVLLV
KRWKKLPAGS KKNWNHVVDA RAGPSLKTTL KPKKMKTLSG SRIKSNQISK LQKEFKRHNS
DAHSTTSSAS PAQSPCYSNQ SDEGSDTEMS AGSSRTPVFS FLDLTYWKRQ KVCCGIIYKG
RFGEVLIDTH LFKPCCSNKK SATEKPEQEG PQSPAISTQE EW
