SHCAF_HUMAN
ID SHCAF_HUMAN Reviewed; 221 AA.
AC Q9NP50; D3DUV8; Q9BSZ8;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=SIN3-HDAC complex-associated factor {ECO:0000312|HGNC:HGNC:30702};
DE AltName: Full=Protein FAM60A;
DE AltName: Full=Tera protein homolog;
GN Name=SINHCAF {ECO:0000312|HGNC:HGNC:30702}; Synonyms=C12orf14, FAM60A;
GN ORFNames=L4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INDUCTION.
RX PubMed=15334068; DOI=10.1038/sj.onc.1207921;
RA Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C.,
RA Cerveny C., Law C.-L., Wahl A., Carter P.;
RT "Suppression subtractive hybridization and expression profiling identifies
RT a unique set of genes overexpressed in non-small-cell lung cancer.";
RL Oncogene 23:7734-7745(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Zhou Y., Yu L., Dai F.Y., Li N.G., Zheng L.H., Zhap S.Y.;
RT "Cloning and expression of a new human cDNA homology to murine Tera mRNA.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Bone marrow;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hepatoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Lung, Lymph, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [10]
RP IDENTIFICATION IN THE SIN3/HDAC COMPLEX, INDUCTION, AND FUNCTION.
RX PubMed=22865885; DOI=10.1074/jbc.m112.382499;
RA Munoz I.M., Macartney T., Sanchez-Pulido L., Ponting C.P., Rocha S.,
RA Rouse J.;
RT "Family with sequence similarity 60A (FAM60A) protein is a cell cycle-
RT fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.";
RL J. Biol. Chem. 287:32346-32353(2012).
RN [11]
RP IDENTIFICATION IN THE SIN3/HDAC COMPLEX, IDENTIFICATION BY MASS
RP SPECTROMETRY, AND FUNCTION.
RX PubMed=22984288; DOI=10.1074/mcp.m112.020255;
RA Smith K.T., Sardiu M.E., Martin-Brown S.A., Seidel C., Mushegian A.,
RA Egidy R., Florens L., Washburn M.P., Workman J.L.;
RT "Human family with sequence similarity 60 member A (FAM60A) protein: a new
RT subunit of the Sin3 deacetylase complex.";
RL Mol. Cell. Proteomics 11:1815-1828(2012).
CC -!- FUNCTION: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this
CC subunit is important for the repression of genes encoding components of
CC the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core
CC component of a SIN3A complex (composed of at least SINHCAF, SIN3A,
CC HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES)
CC cells. Promotes the stability of SIN3A and its presence on chromatin
CC and is essential for maintaining the potential of ES cells to
CC proliferate rapidly, while ensuring a short G1-phase of the cell cycle,
CC thereby preventing premature lineage priming (By similarity).
CC {ECO:0000250|UniProtKB:Q8C8M1, ECO:0000269|PubMed:22865885,
CC ECO:0000269|PubMed:22984288}.
CC -!- SUBUNIT: Interacts with the Sin3/HDAC corepressor complex at least
CC composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L and HDAC1
CC (PubMed:22865885, PubMed:22984288). Found in a complex composed of at
CC least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with
CC SIN3A and OGT (By similarity). {ECO:0000250|UniProtKB:Q8C8M1,
CC ECO:0000269|PubMed:22865885, ECO:0000269|PubMed:22984288}.
CC -!- INTERACTION:
CC Q9NP50; Q13547: HDAC1; NbExp=6; IntAct=EBI-741906, EBI-301834;
CC Q9NP50; Q8N8Y5: ZFP41; NbExp=3; IntAct=EBI-741906, EBI-12224489;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8C8M1}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NP50-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NP50-2; Sequence=VSP_014705;
CC -!- INDUCTION: Peaks during G1 and S phases of the cell cycle in U2OS
CC cells. Up-regulated in squamous cell carcinoma (SCC), adenocarcinoma
CC (AC), colon, ovary, rectum and stomach tumors.
CC {ECO:0000269|PubMed:15334068, ECO:0000269|PubMed:22865885}.
CC -!- SIMILARITY: Belongs to the SINHCAF family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY598323; AAT06734.1; -; mRNA.
DR EMBL; AF087885; AAP97184.1; -; mRNA.
DR EMBL; AF212220; AAF87322.1; -; mRNA.
DR EMBL; AK026932; BAB15592.1; -; mRNA.
DR EMBL; AL157432; CAB75656.1; -; mRNA.
DR EMBL; AC024940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471116; EAW88561.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88562.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88564.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88566.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88567.1; -; Genomic_DNA.
DR EMBL; BC000024; AAH00024.1; -; mRNA.
DR EMBL; BC004462; AAH04462.1; -; mRNA.
DR EMBL; BC071966; AAH71966.1; -; mRNA.
DR CCDS; CCDS8723.1; -. [Q9NP50-1]
DR PIR; T46918; T46918.
DR RefSeq; NP_001129283.1; NM_001135811.1. [Q9NP50-1]
DR RefSeq; NP_001129284.1; NM_001135812.1. [Q9NP50-1]
DR RefSeq; NP_067061.1; NM_021238.2. [Q9NP50-1]
DR RefSeq; XP_016875247.1; XM_017019758.1. [Q9NP50-1]
DR RefSeq; XP_016875248.1; XM_017019759.1. [Q9NP50-1]
DR RefSeq; XP_016875249.1; XM_017019760.1. [Q9NP50-1]
DR RefSeq; XP_016875250.1; XM_017019761.1. [Q9NP50-1]
DR RefSeq; XP_016875251.1; XM_017019762.1. [Q9NP50-1]
DR AlphaFoldDB; Q9NP50; -.
DR BioGRID; 121842; 90.
DR ComplexPortal; CPX-3323; SIN3A histone deacetylase complex, ES cell-specific variant.
DR IntAct; Q9NP50; 73.
DR MINT; Q9NP50; -.
DR STRING; 9606.ENSP00000337477; -.
DR iPTMnet; Q9NP50; -.
DR PhosphoSitePlus; Q9NP50; -.
DR SwissPalm; Q9NP50; -.
DR BioMuta; SINHCAF; -.
DR DMDM; 71151891; -.
DR EPD; Q9NP50; -.
DR jPOST; Q9NP50; -.
DR MassIVE; Q9NP50; -.
DR MaxQB; Q9NP50; -.
DR PaxDb; Q9NP50; -.
DR PeptideAtlas; Q9NP50; -.
DR PRIDE; Q9NP50; -.
DR ProteomicsDB; 81884; -. [Q9NP50-1]
DR ProteomicsDB; 81885; -. [Q9NP50-2]
DR Antibodypedia; 24652; 48 antibodies from 12 providers.
DR DNASU; 58516; -.
DR Ensembl; ENST00000337682.9; ENSP00000337477.4; ENSG00000139146.14. [Q9NP50-1]
DR Ensembl; ENST00000454658.6; ENSP00000393279.2; ENSG00000139146.14. [Q9NP50-1]
DR Ensembl; ENST00000539409.5; ENSP00000443697.1; ENSG00000139146.14. [Q9NP50-2]
DR Ensembl; ENST00000542983.1; ENSP00000439952.1; ENSG00000139146.14. [Q9NP50-2]
DR Ensembl; ENST00000617411.2; ENSP00000479093.1; ENSG00000276371.2. [Q9NP50-1]
DR Ensembl; ENST00000631598.1; ENSP00000488852.1; ENSG00000276371.2. [Q9NP50-2]
DR Ensembl; ENST00000633702.1; ENSP00000488570.1; ENSG00000276371.2. [Q9NP50-1]
DR Ensembl; ENST00000633815.1; ENSP00000488406.1; ENSG00000276371.2. [Q9NP50-2]
DR GeneID; 58516; -.
DR KEGG; hsa:58516; -.
DR MANE-Select; ENST00000337682.9; ENSP00000337477.4; NM_001135812.2; NP_001129284.1.
DR UCSC; uc001rke.4; human. [Q9NP50-1]
DR CTD; 58516; -.
DR DisGeNET; 58516; -.
DR GeneCards; SINHCAF; -.
DR HGNC; HGNC:30702; SINHCAF.
DR HPA; ENSG00000139146; Low tissue specificity.
DR MIM; 615027; gene.
DR neXtProt; NX_Q9NP50; -.
DR OpenTargets; ENSG00000139146; -.
DR PharmGKB; PA134921007; -.
DR VEuPathDB; HostDB:ENSG00000139146; -.
DR eggNOG; ENOG502QSAG; Eukaryota.
DR GeneTree; ENSGT00390000006485; -.
DR HOGENOM; CLU_2704143_0_0_1; -.
DR InParanoid; Q9NP50; -.
DR OMA; TPTCEEN; -.
DR OrthoDB; 1330424at2759; -.
DR PhylomeDB; Q9NP50; -.
DR TreeFam; TF323911; -.
DR PathwayCommons; Q9NP50; -.
DR SignaLink; Q9NP50; -.
DR BioGRID-ORCS; 58516; 291 hits in 1046 CRISPR screens.
DR ChiTaRS; FAM60A; human.
DR GeneWiki; FAM60A; -.
DR GenomeRNAi; 58516; -.
DR Pharos; Q9NP50; Tdark.
DR PRO; PR:Q9NP50; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NP50; protein.
DR Bgee; ENSG00000139146; Expressed in ventricular zone and 101 other tissues.
DR ExpressionAtlas; Q9NP50; baseline and differential.
DR Genevisible; Q9NP50; HS.
DR GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR GO; GO:0016580; C:Sin3 complex; IDA:UniProtKB.
DR GO; GO:0045596; P:negative regulation of cell differentiation; ISS:UniProtKB.
DR GO; GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB.
DR GO; GO:1902455; P:negative regulation of stem cell population maintenance; IC:ComplexPortal.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IC:ComplexPortal.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IC:ComplexPortal.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:1902459; P:positive regulation of stem cell population maintenance; IC:ComplexPortal.
DR InterPro; IPR026065; FAM60A.
DR PANTHER; PTHR13422; PTHR13422; 1.
DR Pfam; PF15396; FAM60A; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..221
FT /note="SIN3-HDAC complex-associated factor"
FT /id="PRO_0000187086"
FT REGION 112..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..148
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014705"
FT VARIANT 117
FT /note="R -> H (in dbSNP:rs2304459)"
FT /id="VAR_049027"
SQ SEQUENCE 221 AA; 24852 MW; F5905C8AAC76AD45 CRC64;
MFGFHKPKMY RSIEGCCICR AKSSSSRFTD SKRYEKDFQS CFGLHETRSG DICNACVLLV
KRWKKLPAGS KKNWNHVVDA RAGPSLKTTL KPKKVKTLSG NRIKSNQISK LQKEFKRHNS
DAHSTTSSAS PAQSPCYSNQ SDDGSDTEMA SGSNRTPVFS FLDLTYWKRQ KICCGIIYKG
RFGEVLIDTH LFKPCCSNKK AAAEKPEEQG PEPLPISTQE W
