ID   SHCAF_PONAB             Reviewed;         221 AA.
AC   Q5RCB7;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=SIN3-HDAC complex-associated factor;
DE   AltName: Full=Protein FAM60A;
DE   AltName: Full=Tera protein homolog;
GN   Name=SINHCAF; Synonyms=FAM60A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this
CC       subunit is important for the repression of genes encoding components of
CC       the TGF-beta signaling pathway. Core component of a SIN3A complex
CC       (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and
CC       TET1) present in embryonic stem (ES) cells. Promotes the stability of
CC       SIN3A and its presence on chromatin and is crucial for maintaining the
CC       potential of ES cells to proliferate rapidly, while ensuring a short
CC       G1-phase of the cell cycle, thereby preventing premature lineage
CC       priming. {ECO:0000250|UniProtKB:Q8C8M1, ECO:0000250|UniProtKB:Q9NP50}.
CC   -!- SUBUNIT: Component of the Sin3/HDAC corepressor complex at least
CC       composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L, HDAC1. Found in a
CC       complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT
CC       and TET1. Interacts with SIN3A and OGT. {ECO:0000250|UniProtKB:Q8C8M1,
CC       ECO:0000250|UniProtKB:Q9NP50}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8C8M1}.
CC   -!- SIMILARITY: Belongs to the SINHCAF family. {ECO:0000305}.
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DR   EMBL; CR858359; CAH90590.1; -; mRNA.
DR   RefSeq; NP_001125318.1; NM_001131846.1.
DR   AlphaFoldDB; Q5RCB7; -.
DR   STRING; 9601.ENSPPYP00000005017; -.
DR   PRIDE; Q5RCB7; -.
DR   GeneID; 100172217; -.
DR   KEGG; pon:100172217; -.
DR   CTD; 58516; -.
DR   eggNOG; ENOG502QSAG; Eukaryota.
DR   InParanoid; Q5RCB7; -.
DR   OrthoDB; 1330424at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016580; C:Sin3 complex; ISS:UniProtKB.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; ISS:UniProtKB.
DR   GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   InterPro; IPR026065; FAM60A.
DR   PANTHER; PTHR13422; PTHR13422; 1.
DR   Pfam; PF15396; FAM60A; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..221
FT                   /note="SIN3-HDAC complex-associated factor"
FT                   /id="PRO_0000187088"
FT   REGION          112..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   221 AA;  24880 MW;  7D7E8D79634A5E94 CRC64;
     MFGFHKPKMY RSIEGCCICR AKSSSSRFTD SKRYEKDFQS CFGLHETRSG DICNACVLLV
     KRWKKLPAGS KKNWNHVVDA RAGPSLKTTL KPKKVKTLSG NRIKSNQISK LQKEFRRHNS
     DAHSTTSSAS PAQSPCYSNQ SDDGSDTEMA SGSNRTPVFS FLDLTYWKRQ KICCGIIYKG
     RFGEVLIDTH LFKPCCSNKK AAAEKPEEQG PEPLPISTQE W