ID   SHCBA_XENLA             Reviewed;         699 AA.
AC   Q6GPE9;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=SHC SH2 domain-binding protein 1 homolog A;
GN   Name=shcbp1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in signaling pathways governing cellular
CC       proliferation. {ECO:0000250|UniProtKB:Q9Z179}.
CC   -!- SUBCELLULAR LOCATION: Midbody {ECO:0000250|UniProtKB:Q8NEM2}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8NEM2}.
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DR   EMBL; BC073190; AAH73190.1; -; mRNA.
DR   RefSeq; NP_001085681.1; NM_001092212.1.
DR   AlphaFoldDB; Q6GPE9; -.
DR   SMR; Q6GPE9; -.
DR   PRIDE; Q6GPE9; -.
DR   DNASU; 444107; -.
DR   GeneID; 444107; -.
DR   KEGG; xla:444107; -.
DR   CTD; 444107; -.
DR   Xenbase; XB-GENE-6255971; shcbp1.S.
DR   OrthoDB; 1276823at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 444107; Expressed in testis and 17 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:2000177; P:regulation of neural precursor cell proliferation; ISS:UniProtKB.
DR   Gene3D; 2.160.20.10; -; 1.
DR   InterPro; IPR039448; Beta_helix.
DR   InterPro; IPR006626; PbH1.
DR   InterPro; IPR012334; Pectin_lyas_fold.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   InterPro; IPR045140; SHCBP1-like.
DR   PANTHER; PTHR14695; PTHR14695; 1.
DR   Pfam; PF13229; Beta_helix; 1.
DR   SMART; SM00710; PbH1; 3.
DR   SUPFAM; SSF51126; SSF51126; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome; Repeat.
FT   CHAIN           1..699
FT                   /note="SHC SH2 domain-binding protein 1 homolog A"
FT                   /id="PRO_0000076317"
FT   REPEAT          480..502
FT                   /note="PbH1 1"
FT   REPEAT          503..524
FT                   /note="PbH1 2"
FT   REPEAT          532..554
FT                   /note="PbH1 3"
FT   COILED          603..627
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   699 AA;  79122 MW;  9266CC8D58632BF3 CRC64;
     MAEAEAQFPP LQDGDDFFHV GSDRCSEELR DVKQVLFQEE DDSASDYGSY KRLGKVTSRT
     VPAGNMLFPD LFQTNNLLFY ERFETYKDYM LGDCKPSEVK EFIAEYLEKA LKPSGWNAIW
     HTDVFDVLVE VTDVEFSSLN AIVRLSEPFL CESHVSSIAL ESIKDLLDVK DQRVPLQEIR
     VVFDESGLYN QTALAIEHLR FFYQQIWRPW DEEEEDYFDY FVRCVEPRLR LHYDILEDRI
     PSGLVAEYSS LLLQCEEVYM QFTNLRNNLS NKDSDSESEL DNVSMVEGMK MDNEMENLKR
     KLKLIENPLL RYLFCYQRNS GCHNVQAKGP RPNGGKVIHV VSTSMSILTL QCLTRERLQP
     ESGNKDLEIQ FHRDPLEAVN ACYEGDLVII CPGLYAVYGL INIMDSIEIE GYGLPDDVVI
     EKMGKGDTFV ACSGAHIKIS NVKFVQHEAV EGIITIHSGK TELDNCVLQC ETTGVTVKKS
     AELLMKYSDL YGAKGAGMEI YPGSKCTLIG NGIHHCRDGI LIKDFIDVVC EIPKITMENN
     VIHNNEGYAV VLVKPSLDIE KNSHNEELEG GHLDDDDKMI EEQTSSNILQ PNLNKAMGVE
     DKAVEHTNNL EKDQGNLAIA KEEVECEYAI DCEEAEGNQV IATELVANTR RKTKLHKKRL
     STLGIVTADD KLTSQEIFVS IVGNQFKRNG KGTFGTFLF