SHD_HUMAN
ID SHD_HUMAN Reviewed; 340 AA.
AC Q96IW2; Q96NC2;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=SH2 domain-containing adapter protein D;
GN Name=SHD;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-270.
RC TISSUE=Neuroblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neuroblastoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as an adapter protein. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96IW2; P08581: MET; NbExp=2; IntAct=EBI-4402781, EBI-1039152;
CC Q96IW2; O43639: NCK2; NbExp=3; IntAct=EBI-4402781, EBI-713635;
CC -!- PTM: Tyrosine phosphorylated by ABL. {ECO:0000250}.
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DR EMBL; AK055673; BAB70981.1; -; mRNA.
DR EMBL; BC007206; AAH07206.1; -; mRNA.
DR CCDS; CCDS12125.1; -.
DR RefSeq; NP_064594.3; NM_020209.3.
DR AlphaFoldDB; Q96IW2; -.
DR SMR; Q96IW2; -.
DR BioGRID; 121283; 17.
DR IntAct; Q96IW2; 9.
DR STRING; 9606.ENSP00000446058; -.
DR iPTMnet; Q96IW2; -.
DR PhosphoSitePlus; Q96IW2; -.
DR BioMuta; SHD; -.
DR DMDM; 74751948; -.
DR MassIVE; Q96IW2; -.
DR PaxDb; Q96IW2; -.
DR PeptideAtlas; Q96IW2; -.
DR PRIDE; Q96IW2; -.
DR ProteomicsDB; 76863; -.
DR Antibodypedia; 2789; 93 antibodies from 22 providers.
DR DNASU; 56961; -.
DR Ensembl; ENST00000543264.7; ENSP00000446058.1; ENSG00000105251.11.
DR GeneID; 56961; -.
DR KEGG; hsa:56961; -.
DR MANE-Select; ENST00000543264.7; ENSP00000446058.1; NM_020209.4; NP_064594.3.
DR UCSC; uc002lzw.3; human.
DR CTD; 56961; -.
DR GeneCards; SHD; -.
DR HGNC; HGNC:30633; SHD.
DR HPA; ENSG00000105251; Group enriched (brain, heart muscle).
DR MIM; 610481; gene.
DR neXtProt; NX_Q96IW2; -.
DR OpenTargets; ENSG00000105251; -.
DR PharmGKB; PA142670918; -.
DR VEuPathDB; HostDB:ENSG00000105251; -.
DR eggNOG; ENOG502QUXW; Eukaryota.
DR GeneTree; ENSGT00940000159004; -.
DR HOGENOM; CLU_029444_0_1_1; -.
DR InParanoid; Q96IW2; -.
DR OMA; FDSPKHR; -.
DR OrthoDB; 1120795at2759; -.
DR PhylomeDB; Q96IW2; -.
DR TreeFam; TF325799; -.
DR PathwayCommons; Q96IW2; -.
DR SignaLink; Q96IW2; -.
DR BioGRID-ORCS; 56961; 12 hits in 1066 CRISPR screens.
DR ChiTaRS; SHD; human.
DR GenomeRNAi; 56961; -.
DR Pharos; Q96IW2; Tbio.
DR PRO; PR:Q96IW2; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96IW2; protein.
DR Bgee; ENSG00000105251; Expressed in mucosa of transverse colon and 120 other tissues.
DR ExpressionAtlas; Q96IW2; baseline and differential.
DR Genevisible; Q96IW2; HS.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IBA:GO_Central.
DR CDD; cd10390; SH2_SHD; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035039; SHD.
DR InterPro; IPR035046; SHD_SH2.
DR PANTHER; PTHR15127:SF33; PTHR15127:SF33; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; SH2 domain.
FT CHAIN 1..340
FT /note="SH2 domain-containing adapter protein D"
FT /id="PRO_0000246773"
FT DOMAIN 240..335
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 138
FT /note="G -> S (in dbSNP:rs2287714)"
FT /id="VAR_027043"
FT VARIANT 270
FT /note="N -> S (in dbSNP:rs888930)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_027044"
FT CONFLICT 170
FT /note="M -> V (in Ref. 1; BAB70981)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 38264 MW; 115EB4062BCA7105 CRC64;
MAKWLRDYLS FGGRRPPPQP PTPDYTESDI LRAYRAQKNL DFEDPYEDAE SRLEPDPAGP
GDSKNPGDAK YGSPKHRLIK VEAADMARAK ALLGGPGEEL EADTEYLDPF DAQPHPAPPD
DGYMEPYDAQ WVMSELPGRG VQLYDTPYEE QDPETADGPP SGQKPRQSRM PQEDERPADE
YDQPWEWKKD HISRAFAVQF DSPEWERTPG SAKELRRPPP RSPQPAERVD PALPLEKQPW
FHGPLNRADA ESLLSLCKEG SYLVRLSETN PQDCSLSLRS SQGFLHLKFA RTRENQVVLG
QHSGPFPSVP ELVLHYSSRP LPVQGAEHLA LLYPVVTQTP
