位置:首页 > 蛋白库 > SHD_MOUSE
SHD_MOUSE
ID   SHD_MOUSE               Reviewed;         343 AA.
AC   O88834; Q3SYI7;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=SH2 domain-containing adapter protein D;
GN   Name=Shd;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AND
RP   PHOSPHORYLATION BY ABL.
RC   TISSUE=Embryo;
RX   PubMed=9315092; DOI=10.1038/sj.onc.1201299;
RA   Oda T., Kujovich J., Reis M., Newman B., Druker B.J.;
RT   "Identification and characterization of two novel SH2 domain-containing
RT   proteins from a yeast two hybrid screen with the ABL tyrosine kinase.";
RL   Oncogene 15:1255-1262(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Stomach;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Jaw, and Limb;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function as an adapter protein.
CC       {ECO:0000269|PubMed:9315092}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O88834-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O88834-2; Sequence=VSP_019860;
CC   -!- TISSUE SPECIFICITY: Specifically expressed in brain.
CC       {ECO:0000269|PubMed:9315092}.
CC   -!- PTM: Tyrosine phosphorylated by ABL. {ECO:0000269|PubMed:9315092}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB018423; BAA33805.1; -; mRNA.
DR   EMBL; AK142491; BAE25084.1; -; mRNA.
DR   EMBL; AK164639; BAE37855.1; -; mRNA.
DR   EMBL; BC103798; AAI03799.1; -; mRNA.
DR   CCDS; CCDS50149.1; -. [O88834-2]
DR   CCDS; CCDS89120.1; -. [O88834-1]
DR   RefSeq; NP_001152995.1; NM_001159523.1. [O88834-2]
DR   RefSeq; NP_033194.1; NM_009168.2. [O88834-1]
DR   RefSeq; XP_011244636.1; XM_011246334.2. [O88834-2]
DR   AlphaFoldDB; O88834; -.
DR   SMR; O88834; -.
DR   STRING; 10090.ENSMUSP00000047656; -.
DR   iPTMnet; O88834; -.
DR   PhosphoSitePlus; O88834; -.
DR   PaxDb; O88834; -.
DR   PeptideAtlas; O88834; -.
DR   PRIDE; O88834; -.
DR   ProteomicsDB; 256999; -. [O88834-1]
DR   ProteomicsDB; 257000; -. [O88834-2]
DR   Antibodypedia; 2789; 93 antibodies from 22 providers.
DR   DNASU; 20420; -.
DR   Ensembl; ENSMUST00000044216; ENSMUSP00000047656; ENSMUSG00000039154. [O88834-1]
DR   Ensembl; ENSMUST00000223629; ENSMUSP00000153605; ENSMUSG00000039154. [O88834-2]
DR   GeneID; 20420; -.
DR   KEGG; mmu:20420; -.
DR   UCSC; uc008dal.2; mouse. [O88834-1]
DR   UCSC; uc008dam.2; mouse. [O88834-2]
DR   CTD; 56961; -.
DR   MGI; MGI:1099461; Shd.
DR   VEuPathDB; HostDB:ENSMUSG00000039154; -.
DR   eggNOG; ENOG502QTRD; Eukaryota.
DR   GeneTree; ENSGT00940000159004; -.
DR   HOGENOM; CLU_029444_0_1_1; -.
DR   InParanoid; O88834; -.
DR   OMA; FDSPKHR; -.
DR   OrthoDB; 1120795at2759; -.
DR   PhylomeDB; O88834; -.
DR   TreeFam; TF325799; -.
DR   BioGRID-ORCS; 20420; 0 hits in 74 CRISPR screens.
DR   ChiTaRS; Shd; mouse.
DR   PRO; PR:O88834; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; O88834; protein.
DR   Bgee; ENSMUSG00000039154; Expressed in embryonic brain and 142 other tissues.
DR   ExpressionAtlas; O88834; baseline and differential.
DR   Genevisible; O88834; MM.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IBA:GO_Central.
DR   CDD; cd10390; SH2_SHD; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR035039; SHD.
DR   InterPro; IPR035046; SHD_SH2.
DR   PANTHER; PTHR15127:SF33; PTHR15127:SF33; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Phosphoprotein; Reference proteome; SH2 domain.
FT   CHAIN           1..343
FT                   /note="SH2 domain-containing adapter protein D"
FT                   /id="PRO_0000246774"
FT   DOMAIN          225..320
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          1..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         93
FT                   /note="E -> EQ (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_019860"
SQ   SEQUENCE   343 AA;  38481 MW;  C55412EEA5AC40EC CRC64;
     MAKWLRDYLN LGSRRPPPQP PTPDYTESDI LRAYREQKDL DFEDPYEDSN GRAEPEVTGS
     GDPKYNSPRH RLIKVEAADM ARAKALLGSP GEEPEAETEY SDPFDAQPQP PAPNSGYMEP
     YDARSVSSEQ PSRAVQLYDT PYEEQATKPE DGGSSGQSRR PLEDERPADE YDQPWEWKKD
     HISRAFAVQF DGPDWERTPC STKEPWRPQP AERVDTALAL EKQPWFHGPL SRAEAENLLS
     LCKEGSYLVR LSETRAQDCI LSLRSNQGSM HLKFARTREN QVVLGQHSGP FPSIPELVLH
     YSARPLPVQG AEHLALLYPV TSSQSSQGPC TLAAKPERGQ GDP
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024