ID   SHE10_KLULA             Reviewed;         636 AA.
AC   Q6CYD8;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Outer spore wall assembly protein SHE10 {ECO:0000250|UniProtKB:P53075};
DE   AltName: Full=Sensitivity to high expression protein 10 {ECO:0000250|UniProtKB:P53075};
DE   Flags: Precursor;
GN   Name=SHE10 {ECO:0000250|UniProtKB:P53075}; OrderedLocusNames=KLLA0A01177g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in spore wall assembly. May be a component of the
CC       mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease
CC       involved in the cleaving RNA transcripts to generate primers for DNA
CC       replication in mitochondria. {ECO:0000250|UniProtKB:P53075}.
CC   -!- SUBUNIT: Component of the mitochondria-localized RNase mitochondrial
CC       RNA-processing (RNase MRP) composed of one single RNA encoded by the
CC       NME1 gene and at least 31 proteins. Absent in the nucleus-localized
CC       RNase MRP (NuMRP). {ECO:0000250|UniProtKB:P53075}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P53075}.
CC   -!- SIMILARITY: Belongs to the SHE10 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382121; CAH02639.1; -; Genomic_DNA.
DR   RefSeq; XP_451051.1; XM_451051.1.
DR   AlphaFoldDB; Q6CYD8; -.
DR   STRING; 28985.XP_451051.1; -.
DR   EnsemblFungi; CAH02639; CAH02639; KLLA0_A01177g.
DR   GeneID; 2896462; -.
DR   KEGG; kla:KLLA0_A01177g; -.
DR   eggNOG; ENOG502QT2T; Eukaryota.
DR   HOGENOM; CLU_023952_1_0_1; -.
DR   InParanoid; Q6CYD8; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Coiled coil; Mitochondrion; Reference proteome; Ribonucleoprotein; Signal;
KW   Sporulation.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..636
FT                   /note="Outer spore wall assembly protein SHE10"
FT                   /id="PRO_0000408908"
FT   REGION          565..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          433..460
FT                   /evidence="ECO:0000255"
FT   COILED          551..584
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        579..607
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   636 AA;  73597 MW;  F3283CEA1FD191AE CRC64;
     MRLVSKLLKA LLVLLLAFGS VRYSCDNYTS GELQICKYTA PQHYRAIIGG RFPQVIKYSD
     SLVAKYETVV VPRVGSAVIH VKDTVEQKVV PSVIRTSRSS LSLVYTKVYP RVVKYAFIAE
     SSLCRWYLQL CHQYTVYVKP VVINLYYKTM IKYPFLEHAI YSVQAQYKIM ETHVFKYYNI
     ISYNVQVWND KYGYGRLSRN KIFIRMKSTV VEHLIIWYRY VNNRCRKMWR ENLCPIINKS
     RERFAYHGGV RPESATTDPD DESIFYEDDD VDEYTETSTI VLTVTQTANS ALDLKATPSA
     SGLIVDECDM SMEEMLRNDF MSWKITIENK LSNTMKDFEN DINEFAQEKL DHIQPTLADL
     LKRASNTSQT NFQIITKAIM DVNCTESVDP KTNKTIWFDQ NNTQLPKYMT RELMREYFSA
     AHSQFDALSQ EIRAHLRKLA DEVNDHVEVL RQENVELFEE WADVMITEWS KNLAYVDVAV
     NEEKLADLEK EQRKNWKDFM KLKRQVIKTR DTLMEHPVKL DSLQSFVNTV QQSLKTLSHE
     NGEYLYILRS KANLEFQARE ALERQQREKE KAESASMKAS TEFELSSSSF SSSSPSTASS
     CTASSTSTAS LLAVEKTIAL EDLQSYYQNV SSTDSL