ID   SHE10_LACTC             Reviewed;         673 AA.
AC   C5DLJ3;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Outer spore wall assembly protein SHE10 {ECO:0000250|UniProtKB:P53075};
DE   AltName: Full=Sensitivity to high expression protein 10 {ECO:0000250|UniProtKB:P53075};
DE   Flags: Precursor;
GN   Name=SHE10 {ECO:0000250|UniProtKB:P53075}; OrderedLocusNames=KLTH0G01166g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Involved in spore wall assembly. May be a component of the
CC       mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease
CC       involved in the cleaving RNA transcripts to generate primers for DNA
CC       replication in mitochondria. {ECO:0000250|UniProtKB:P53075}.
CC   -!- SUBUNIT: Component of the mitochondria-localized RNase mitochondrial
CC       RNA-processing (RNase MRP) composed of one single RNA encoded by the
CC       NME1 gene and at least 31 proteins. Absent in the nucleus-localized
CC       RNase MRP (NuMRP). {ECO:0000250|UniProtKB:P53075}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P53075}.
CC   -!- SIMILARITY: Belongs to the SHE10 family. {ECO:0000305}.
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DR   EMBL; CU928171; CAR24654.1; -; Genomic_DNA.
DR   RefSeq; XP_002555091.1; XM_002555045.1.
DR   AlphaFoldDB; C5DLJ3; -.
DR   SMR; C5DLJ3; -.
DR   STRING; 559295.C5DLJ3; -.
DR   PRIDE; C5DLJ3; -.
DR   EnsemblFungi; CAR24654; CAR24654; KLTH0G01166g.
DR   GeneID; 8293349; -.
DR   KEGG; lth:KLTH0G01166g; -.
DR   eggNOG; ENOG502QT2T; Eukaryota.
DR   HOGENOM; CLU_023952_1_0_1; -.
DR   InParanoid; C5DLJ3; -.
DR   OMA; DEFQAWS; -.
DR   OrthoDB; 1383951at2759; -.
DR   Proteomes; UP000002036; Chromosome G.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Coiled coil; Mitochondrion; Reference proteome; Ribonucleoprotein; Signal;
KW   Sporulation.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..673
FT                   /note="Outer spore wall assembly protein SHE10"
FT                   /id="PRO_0000408909"
FT   REGION          530..551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          587..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          503..568
FT                   /evidence="ECO:0000255"
FT   COILED          617..647
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        601..615
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..673
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  78644 MW;  490F6314EE816AE8 CRC64;
     MRRVRGVGNL LVTILVVLIG FKQARKYCES NEAEFCRLTS LSRASPWWNE HIDPYWDSYV
     SPCVTKIHDY EHKLDEWAAP RIDRAYYQVQ DIVETKVVPV TYKWYKTVQF KTQVYYNGHF
     VPFLGHARIL AKQWLASEGF FQRLYLHVQQ GLFCLRNWSL WVWNGSLEAF NEIHSWSGHA
     LQEISNKFSV TENQSGEPVT DEDPSDTDES KYYDAEYFEG EQGDYNEDDE TVYLTSTIIE
     TVTLSDEKQL DKSTSAANGD DGSSLDVPLR DLVQDEFQAW SNTVEQKASN TLTQFDSEVE
     ELVEAKLSKA QPNITGLLQG ISESFQSHYR IINRAILDVD CTMELDPETG EQLYFNKDGT
     QLRKYVTRPL MREFFSSAHA HVDERLEMVR ARLEKFVAAV NKEVEQVRQE HLEVYEEWGD
     VMVSEWSKRM AYVDVVAAMG AEDMNQQQHD NWKRFLKLKK QVVNTRDLLM QHPAKLERLQ
     KFLNDIQFTL MALQRDAGEY LFILRSQANI AFQTREKLER EREEEERRKL EQERQIQEQK
     EREQQELAEN EARAARERLA LEQGQGQEQL EQNSDEAFFS MEDITATPLG ADDNTDYENA
     LDDADSQLSE SGDSEDNFYD SYEGDEEDAS RELERLERES AERETLDRLE LGQRQKLQEE
     QHRDELHHSS QAN