ID   SHE1_CAEBR              Reviewed;         830 AA.
AC   A8XDR5;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=F-box protein she-1 {ECO:0000303|PubMed:19836240};
DE   AltName: Full=Protein spermless hermaphrodites 1 {ECO:0000312|WormBase:CBG11663};
GN   Name=she-1 {ECO:0000312|WormBase:CBG11663};
GN   ORFNames=CBG11663 {ECO:0000312|WormBase:CBG11663};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP30785.1,
RC   ECO:0000312|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION, FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, AND
RP   MUTAGENESIS OF ARG-49 AND GLY-111.
RX   PubMed=19836240; DOI=10.1016/j.cub.2009.09.042;
RA   Guo Y., Lang S., Ellis R.E.;
RT   "Independent recruitment of F box genes to regulate hermaphrodite
RT   development during nematode evolution.";
RL   Curr. Biol. 19:1853-1860(2009).
CC   -!- FUNCTION: Sex-determining factor which regulates hermaphrodite
CC       development. {ECO:0000269|PubMed:19836240}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from early larval stages through to
CC       adulthood. {ECO:0000269|PubMed:19836240}.
CC   -!- DISRUPTION PHENOTYPE: Temperature-sensitive phenotype in which XX
CC       animals are self-sterile, do not produce spermatocytes, but ovulate and
CC       produce progeny when mated with males; XO animals develop as males, but
CC       some switch to oogenesis in later life. Animals do not produce fog-3
CC       proteins responsible for controlling germ cell fate. RNAi-mediated
CC       knock-down results in 95% female progeny.
CC       {ECO:0000269|PubMed:19836240}.
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DR   EMBL; HE600992; CAP30785.1; -; Genomic_DNA.
DR   RefSeq; XP_002632771.1; XM_002632725.1.
DR   AlphaFoldDB; A8XDR5; -.
DR   GeneID; 8574767; -.
DR   KEGG; cbr:CBG_11663; -.
DR   CTD; 8574767; -.
DR   WormBase; CBG11663; CBP17250; WBGene00032753; Cbr-she-1.
DR   eggNOG; ENOG502TJWS; Eukaryota.
DR   HOGENOM; CLU_341708_0_0_1; -.
DR   InParanoid; A8XDR5; -.
DR   OrthoDB; 1888952at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR042317; She-1-like.
DR   PANTHER; PTHR31006; PTHR31006; 2.
DR   Pfam; PF00646; F-box; 1.
DR   SMART; SM00256; FBOX; 2.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; Reference proteome; Repeat;
KW   Sexual differentiation.
FT   CHAIN           1..830
FT                   /note="F-box protein she-1"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000432996"
FT   DOMAIN          24..69
FT                   /note="F-box 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          523..563
FT                   /note="F-box 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   MUTAGEN         49
FT                   /note="R->W: In v35; transforms XX hermaphrodites to
FT                   females."
FT                   /evidence="ECO:0000269|PubMed:19836240"
FT   MUTAGEN         111
FT                   /note="G->E: In v51; transforms XX hermaphrodites to
FT                   females."
FT                   /evidence="ECO:0000269|PubMed:19836240"
SQ   SEQUENCE   830 AA;  96285 MW;  F4BDF3A50F0834F5 CRC64;
     MSSHLKNLTE NFENLAINPI FNTNWCDMPA EIKVECVGKM ELTERLSLRS TAKAERSLVD
     SQKINIRRCA IHGLPEIRRV TLASKTGKIV FRAFRSANKE FEFLKYIWKI GVFENLYIWL
     DGKDSKEKLE NFNGTIAAKS IDFHFCDEEF IVAILGKVKN GVESITMNAD RGISYSVNEI
     LKISHVQNVK YWQIDNYKRM SVLWKVAQVW IDISSKIGTT FQLSTEVYGL FHEFLQHFVD
     RIVSISQIRV RIRTNHPDRH ILLELEFDGF VEFQHSFKFF RLMDMTANTR QKKVAAALLL
     LQEQESVLLT VCRPYQLEEG LEVIRQDLFS TFLRLNQYMI STEQTKKYLG VELEHFNFLR
     NLCSDDISRI DSIPAPVRIH IFLKYAREAV CVILPGPAQF EGELEFLVSR VGGDDESMYR
     VVKKSSCICL QKENCHCHCG ACGYRHSCTC LVQETGVCCK HIHMVILRNG SMTPSFFLKL
     TCTPVSLVDV DQAEKEKMLM SSDINNSSKI TEKSTAEPIY DSNWCDMPDD IKLECIGKME
     LCERLSLRCS AKAERSLVDS QKIEFHEGVF LREYEDSSFL FSRNDKVVFW KRTKEINEAF
     ELMKYIKKVG VFEHLKIFSR GVADCERFLA DDGLFTAKKM NLVHCDIDST IAVLRKMKND
     VESIEMNGDE ITSGKLAEIL TISHIQNVPY WHIDCYEETD SLHKVAQMWI DKNSKIDSTF
     QISVNANGSF AEFLEHFKDR VVSQSDRKVR IHTNNPDRHI LLERGLDEVV KIDYEIYRLM
     VISAEMKESE YDDNCKEWIY KMNPEIHYYD SESSFEARDD DFEWSDGEEA