ID   SHE1_KLULA              Reviewed;         331 AA.
AC   Q6CNI5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Mitotic spindle-associated protein SHE1;
GN   Name=SHE1; OrderedLocusNames=KLLA0E12331g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May have a role related to the spindle integrity, which is
CC       essential for proper chromosome segregation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE1 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99591.1; -; Genomic_DNA.
DR   RefSeq; XP_454504.1; XM_454504.1.
DR   AlphaFoldDB; Q6CNI5; -.
DR   STRING; 28985.XP_454504.1; -.
DR   EnsemblFungi; CAG99591; CAG99591; KLLA0_E12343g.
DR   GeneID; 2894570; -.
DR   KEGG; kla:KLLA0_E12343g; -.
DR   eggNOG; ENOG502S5DY; Eukaryota.
DR   HOGENOM; CLU_821841_0_0_1; -.
DR   InParanoid; Q6CNI5; -.
DR   OMA; KINSAHR; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   InterPro; IPR031401; She1.
DR   Pfam; PF17077; Msap1; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm; Cytoskeleton;
KW   Mitosis; Reference proteome.
FT   CHAIN           1..331
FT                   /note="Mitotic spindle-associated protein SHE1"
FT                   /id="PRO_0000333422"
FT   REGION          90..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..168
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..301
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   331 AA;  37694 MW;  528BD9469D203A43 CRC64;
     MDKENMPPLL DGHQMIEYIG VSKRLGNNVL QELEQRASNL LPNVSPEKTR LMHLGHDSEM
     KNSISMKFQD KHEKRFQVMD SIDTHYSLAK YSGMPQTPGK RKNGSDADET SVAVNLGSPG
     SVKKKQKSVG NVFSPVTDIT HRIRRLRVRI TTPNERERTE RDRRRNIISN TPLSRQRQLH
     ESIPTFAQPT ATSLKRKQMN NPLHKLVASD NNNVESQPKP KPAKPRHGDI FRNLNQSEKQ
     ASHPRSAPVP KQQRIPQSKS VFERLYEQST ISRSNSSKNL LKQEKTTSSD GNTSQIPRSK
     TQHDLHGGMK NARLTKSTTL QNVALDRPQW R