ID   SHE2_CANGA              Reviewed;         244 AA.
AC   Q6FMJ2;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=SWI5-dependent HO expression protein 2;
GN   Name=SHE2; OrderedLocusNames=CAGL0K07612g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: RNA-binding protein that binds specific mRNAs including the
CC       ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the
CC       mRNA localization machinery that restricts accumulation of certain
CC       proteins to the bud and in the daughter cell (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer and homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P36068}. Nucleus
CC       {ECO:0000250|UniProtKB:P36068}. Note=Shuttles between the nucleus and
CC       cytoplasm and is exported in an mRNA-dependent manner. The presence in
CC       the nucleus is essential for PUF6 and LOC1 to bind the ASH1 mRNA.
CC       {ECO:0000250|UniProtKB:P36068}.
CC   -!- SIMILARITY: Belongs to the SHE2 family. {ECO:0000305}.
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DR   EMBL; CR380957; CAG61515.1; -; Genomic_DNA.
DR   RefSeq; XP_448552.1; XM_448552.1.
DR   AlphaFoldDB; Q6FMJ2; -.
DR   SMR; Q6FMJ2; -.
DR   STRING; 5478.XP_448552.1; -.
DR   EnsemblFungi; CAG61515; CAG61515; CAGL0K07612g.
DR   GeneID; 2890384; -.
DR   KEGG; cgr:CAGL0K07612g; -.
DR   CGD; CAL0134471; CAGL0K07612g.
DR   VEuPathDB; FungiDB:CAGL0K07612g; -.
DR   eggNOG; ENOG502RXWH; Eukaryota.
DR   HOGENOM; CLU_1129832_0_0_1; -.
DR   InParanoid; Q6FMJ2; -.
DR   OMA; HFVKFTQ; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:EnsemblFungi.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0008298; P:intracellular mRNA localization; IEA:EnsemblFungi.
DR   GO; GO:0007533; P:mating type switching; IEA:EnsemblFungi.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.200.20; -; 1.
DR   InterPro; IPR024261; RNA-bd_She2.
DR   InterPro; IPR036827; She2_dom_sf.
DR   Pfam; PF11435; She2p; 1.
DR   SUPFAM; SSF116942; SSF116942; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA transport; Nucleus; Reference proteome; RNA-binding;
KW   Transport.
FT   CHAIN           1..244
FT                   /note="SWI5-dependent HO expression protein 2"
FT                   /id="PRO_0000408917"
SQ   SEQUENCE   244 AA;  28351 MW;  B2B231691549DF74 CRC64;
     MSREEQPYIV ATDGIVDALT KISSVFSAYL SANIHILNKY INYLRRVTSL KNERSIMIKI
     VKKLRFFNDT LLSTDLAQLQ TTYEGEEPEL ALNIQTFASY LVKCLETIDL LNYFLLKPLQ
     KELIAKTLNF DLVFPEDITD TVEDTYNHFV KFTQWSIESL SIDDPLLDIE VVQFSLRCAE
     EDQSYAEETD NIFLQEVLPV KDSQEYETLT LQWLDVLNGK LAILGERFEK VADDWYKKFG
     KNRS