ID   SHE2_KLULA              Reviewed;         241 AA.
AC   Q6CVF1;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=SWI5-dependent HO expression protein 2;
GN   Name=SHE2; OrderedLocusNames=KLLA0B12518g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: RNA-binding protein that binds specific mRNAs including the
CC       ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the
CC       mRNA localization machinery that restricts accumulation of certain
CC       proteins to the bud and in the daughter cell (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer and homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P36068}. Nucleus
CC       {ECO:0000250|UniProtKB:P36068}. Note=Shuttles between the nucleus and
CC       cytoplasm and is exported in an mRNA-dependent manner. The presence in
CC       the nucleus is essential for PUF6 and LOC1 to bind the ASH1 mRNA.
CC       {ECO:0000250|UniProtKB:P36068}.
CC   -!- SIMILARITY: Belongs to the SHE2 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02481.1; -; Genomic_DNA.
DR   RefSeq; XP_452088.1; XM_452088.1.
DR   AlphaFoldDB; Q6CVF1; -.
DR   SMR; Q6CVF1; -.
DR   STRING; 28985.XP_452088.1; -.
DR   EnsemblFungi; CAH02481; CAH02481; KLLA0_B12518g.
DR   GeneID; 2897466; -.
DR   KEGG; kla:KLLA0_B12518g; -.
DR   eggNOG; ENOG502RXWH; Eukaryota.
DR   HOGENOM; CLU_1129832_0_0_1; -.
DR   InParanoid; Q6CVF1; -.
DR   OMA; HFVKFTQ; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:EnsemblFungi.
DR   GO; GO:1990825; F:sequence-specific mRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0008298; P:intracellular mRNA localization; IEA:EnsemblFungi.
DR   GO; GO:0007533; P:mating type switching; IEA:EnsemblFungi.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.200.20; -; 1.
DR   InterPro; IPR024261; RNA-bd_She2.
DR   InterPro; IPR036827; She2_dom_sf.
DR   Pfam; PF11435; She2p; 1.
DR   SUPFAM; SSF116942; SSF116942; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA transport; Nucleus; Reference proteome; RNA-binding;
KW   Transport.
FT   CHAIN           1..241
FT                   /note="SWI5-dependent HO expression protein 2"
FT                   /id="PRO_0000408918"
SQ   SEQUENCE   241 AA;  28078 MW;  7A8C39C5AA3CB6EB CRC64;
     MAYCQVVISK EILDAVLQLV STYSNYISRY VDYLNNLIAV QRRVSTLRFE RMTLIKYVKK
     LRFMADVLHS WSFEGENDLI GKRLNEVIDP LGAYLIKVFE ILDLLNFYIT QPMRGETISK
     TLNEDLVVSE ETIVCINDSY RIYIKGIQWL VESISERNGN CPHLALELIE FTRKCAIEDE
     VDFTASEDIL LQDVAIVEVE EEYVDLLHDW SAILVQKQTE MKELFSEDSK RWASMTKPVK
     K