ID   SHE2_LACTC              Reviewed;         236 AA.
AC   C5DGE2;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=SWI5-dependent HO expression protein 2;
GN   Name=SHE2; OrderedLocusNames=KLTH0D04598g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: RNA-binding protein that binds specific mRNAs including the
CC       ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the
CC       mRNA localization machinery that restricts accumulation of certain
CC       proteins to the bud and in the daughter cell (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer and homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P36068}. Nucleus
CC       {ECO:0000250|UniProtKB:P36068}. Note=Shuttles between the nucleus and
CC       cytoplasm and is exported in an mRNA-dependent manner. The presence in
CC       the nucleus is essential for PUF6 and LOC1 to bind the ASH1 mRNA.
CC       {ECO:0000250|UniProtKB:P36068}.
CC   -!- SIMILARITY: Belongs to the SHE2 family. {ECO:0000305}.
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DR   EMBL; CU928168; CAR22484.1; -; Genomic_DNA.
DR   RefSeq; XP_002552922.1; XM_002552876.1.
DR   AlphaFoldDB; C5DGE2; -.
DR   SMR; C5DGE2; -.
DR   STRING; 559295.C5DGE2; -.
DR   EnsemblFungi; CAR22484; CAR22484; KLTH0D04598g.
DR   GeneID; 8295148; -.
DR   KEGG; lth:KLTH0D04598g; -.
DR   eggNOG; ENOG502RXWH; Eukaryota.
DR   HOGENOM; CLU_1129832_0_0_1; -.
DR   InParanoid; C5DGE2; -.
DR   OMA; HFVKFTQ; -.
DR   OrthoDB; 1346654at2759; -.
DR   Proteomes; UP000002036; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.200.20; -; 1.
DR   InterPro; IPR024261; RNA-bd_She2.
DR   InterPro; IPR036827; She2_dom_sf.
DR   Pfam; PF11435; She2p; 1.
DR   SUPFAM; SSF116942; SSF116942; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA transport; Nucleus; Reference proteome; RNA-binding;
KW   Transport.
FT   CHAIN           1..236
FT                   /note="SWI5-dependent HO expression protein 2"
FT                   /id="PRO_0000408919"
SQ   SEQUENCE   236 AA;  27512 MW;  AC1CAB38A536DFEC CRC64;
     MKNVTFPANE NVLKSLQLAI QSYSNYLSSY IDALNKYISH QRRVSTLRFE RATLIKYVKK
     LRFFNEELMS MDMVQQYRGG NLIKTAVCSL ASFFIRCLEV MDLLNYYLTQ SLKNETISKT
     LNRDLVVSED CVVFLESTYR HYVKFTQWML EALDIHDATL TVEVLQFARK CAKEDGLDLE
     ETDDILLQEV GVVSSASEYQ ELLDEWCLVL SEQYMGLTKA FEAETTRWSE IFEGRK