ID   SHE2_VANPO              Reviewed;         240 AA.
AC   A7TDZ7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=SWI5-dependent HO expression protein 2;
GN   Name=SHE2; ORFNames=Kpol_1018p156;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: RNA-binding protein that binds specific mRNAs including the
CC       ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the
CC       mRNA localization machinery that restricts accumulation of certain
CC       proteins to the bud and in the daughter cell (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer and homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P36068}. Nucleus
CC       {ECO:0000250|UniProtKB:P36068}. Note=Shuttles between the nucleus and
CC       cytoplasm and is exported in an mRNA-dependent manner. The presence in
CC       the nucleus is essential for PUF6 and LOC1 to bind the ASH1 mRNA.
CC       {ECO:0000250|UniProtKB:P36068}.
CC   -!- SIMILARITY: Belongs to the SHE2 family. {ECO:0000305}.
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DR   EMBL; DS480378; EDO19617.1; -; Genomic_DNA.
DR   RefSeq; XP_001647475.1; XM_001647425.1.
DR   AlphaFoldDB; A7TDZ7; -.
DR   SMR; A7TDZ7; -.
DR   STRING; 436907.A7TDZ7; -.
DR   EnsemblFungi; EDO19617; EDO19617; Kpol_1018p156.
DR   GeneID; 5547981; -.
DR   KEGG; vpo:Kpol_1018p156; -.
DR   eggNOG; ENOG502RXWH; Eukaryota.
DR   HOGENOM; CLU_1129832_0_0_1; -.
DR   InParanoid; A7TDZ7; -.
DR   OMA; HFVKFTQ; -.
DR   OrthoDB; 1346654at2759; -.
DR   PhylomeDB; A7TDZ7; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.200.20; -; 1.
DR   InterPro; IPR024261; RNA-bd_She2.
DR   InterPro; IPR036827; She2_dom_sf.
DR   Pfam; PF11435; She2p; 1.
DR   SUPFAM; SSF116942; SSF116942; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA transport; Nucleus; Reference proteome; RNA-binding;
KW   Transport.
FT   CHAIN           1..240
FT                   /note="SWI5-dependent HO expression protein 2"
FT                   /id="PRO_0000408920"
SQ   SEQUENCE   240 AA;  28098 MW;  FB216372B5430E94 CRC64;
     MAETANNGEL QNVTLKDIFE QIKEVFSTYI SSYVHILNKF IGILRKVSTM RFERSTLIKY
     VKKLRFFNET LLNYEFPLLT SSDITTVRLQ VKAIGSFFIK FLEMQDILNY YLTQSVQNEV
     ISKTLNYKLN FPDAAIERIE DSYNHFVKFT QWMMQSLLID DELSQIEVIQ FSIKCAVEDN
     VDLTQTTNIF LQEVAPVESL AEYMELSEEW VAILKDLIAR MENEFSLAVV QWTEATEKKK