ID   SHE3_LACTC              Reviewed;         423 AA.
AC   C5DLA5;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=SWI5-dependent HO expression protein 3;
GN   Name=SHE3; OrderedLocusNames=KLTH0F11396g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: RNA-binding protein that binds specific mRNAs including the
CC       ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the
CC       mRNA localization machinery that restricts accumulation of certain
CC       proteins to the bud and in the daughter cell. Required for the delivery
CC       of cortical endoplasmic reticulum into the emerging bud (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE3 family. {ECO:0000305}.
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DR   EMBL; CU928170; CAR24256.1; -; Genomic_DNA.
DR   RefSeq; XP_002554693.1; XM_002554647.1.
DR   AlphaFoldDB; C5DLA5; -.
DR   SMR; C5DLA5; -.
DR   STRING; 559295.C5DLA5; -.
DR   PRIDE; C5DLA5; -.
DR   EnsemblFungi; CAR24256; CAR24256; KLTH0F11396g.
DR   GeneID; 8292906; -.
DR   KEGG; lth:KLTH0F11396g; -.
DR   eggNOG; ENOG502QSQX; Eukaryota.
DR   HOGENOM; CLU_038734_0_0_1; -.
DR   InParanoid; C5DLA5; -.
DR   OMA; HFMANIN; -.
DR   OrthoDB; 1540192at2759; -.
DR   Proteomes; UP000002036; Chromosome F.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0048309; P:endoplasmic reticulum inheritance; IEA:InterPro.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031398; She3.
DR   Pfam; PF17078; SHE3; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; Membrane; mRNA transport;
KW   Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..423
FT                   /note="SWI5-dependent HO expression protein 3"
FT                   /id="PRO_0000408933"
FT   REGION          284..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          101..260
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        284..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..398
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  46671 MW;  C789E649A8119EA6 CRC64;
     MSNQEVDFQA AHLESPMKMS PSKVSMNHGA FMANMQNGYS PTREGATAGS SSTRVIEALH
     AQIDSLTKTN LDLTVQSNNL LSRLESSNNT QSKHLESIST LKHENDNLGL MLSRKERRVR
     DLEQQLSQLK HSYEEAAMDN KTMRHQLQTS GQREGTLENQ LQQLQVQYDA LVDGQKRYRE
     KYDLEVEELK KSLQDFKRDN EMYLTKNIQT VVSNNTALQT KINQYSGKYK NLESLSQQHM
     QELSREVEGM ASKLDLAKWE KLYEESRNMA IEYSEKTNVP LSPSFLAQHG AKSGSRSPST
     SSSSTFVHPS QIRVPKVRHS SSSAKRSSFY GSNVSVPGGT VPGVKQPSAS PTTPSSGGLP
     GVRRSSSVRG SSSSSRNSSG DLASAESAAQ SQKGASKNSA NNKKKRMSSH SYSKSNGFSF
     GEP