ID   SHE3_LODEL              Reviewed;         500 AA.
AC   A5E5U9;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=SWI5-dependent HO expression protein 3;
GN   Name=SHE3; ORFNames=LELG_04988;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: RNA-binding protein that binds specific mRNAs including the
CC       ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the
CC       mRNA localization machinery that restricts accumulation of certain
CC       proteins to the bud and in the daughter cell. Required for the delivery
CC       of cortical endoplasmic reticulum into the emerging bud (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE3 family. {ECO:0000305}.
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DR   EMBL; CH981530; EDK46807.1; -; Genomic_DNA.
DR   RefSeq; XP_001524175.1; XM_001524125.1.
DR   AlphaFoldDB; A5E5U9; -.
DR   SMR; A5E5U9; -.
DR   STRING; 379508.A5E5U9; -.
DR   EnsemblFungi; EDK46807; EDK46807; LELG_04988.
DR   GeneID; 5230987; -.
DR   KEGG; lel:LELG_04988; -.
DR   VEuPathDB; FungiDB:LELG_04988; -.
DR   eggNOG; ENOG502QSQX; Eukaryota.
DR   HOGENOM; CLU_042310_0_0_1; -.
DR   InParanoid; A5E5U9; -.
DR   OrthoDB; 1158686at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0048309; P:endoplasmic reticulum inheritance; IEA:InterPro.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   InterPro; IPR031398; She3.
DR   Pfam; PF17078; SHE3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; Membrane; mRNA transport;
KW   Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..500
FT                   /note="SWI5-dependent HO expression protein 3"
FT                   /id="PRO_0000408934"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          41..185
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        324..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..433
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   500 AA;  55370 MW;  24F11A49D0814464 CRC64;
     MAGDSASLSL SPIKSDKAAV VSESPVKMKP GSSSSKVIDT LHTTIDSLSL EIATLKQTNQ
     ELSRKSQVAT AKNDSFVDQL ANLKHENDML SALLKRKERR ILDLEDQNSE LSNSVESLNM
     LTKQMKMRCE KLSDSSMQSM AEYERLKISY DALVASCNEY KQHYKTELDT LQKSLDTYKQ
     ENHKQWETLN ELISSNDKDI DTLLDSLNNK KKLMDNIYVN KNTKVLTMLS TLATLVKAHG
     TESKNVLGDN AQTIEFLLEK YPDLEEKILE KEQIEIDINS ILYASKDALE NTSFDEEDVT
     LINSPELEPS SDGNFPAQQL QKRNNVGNQQ TSNSNNSNNS NSNSSSNSNS NSNSNNGSSN
     HAQNKRKGKR TPLSGNSPSV HMPSMWSNNS SSSSTSHTPF NSQNQNNHHH NSHHQQQLHA
     RSNNTNKSYG NLSHDLQHGH LPKKHAAINN ITNTYSRSSG GGGGGHNSGN NNGPNAASNS
     NNNNNRRRSG YYKKAVSSQT