ID   SHE3_PICST              Reviewed;         442 AA.
AC   A3LXM3;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=SWI5-dependent HO expression protein 3;
GN   Name=SHE3; ORFNames=PICST_62098;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: RNA-binding protein that binds specific mRNAs including the
CC       ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the
CC       mRNA localization machinery that restricts accumulation of certain
CC       proteins to the bud and in the daughter cell. Required for the delivery
CC       of cortical endoplasmic reticulum into the emerging bud (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE3 family. {ECO:0000305}.
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DR   EMBL; CP000500; ABN67489.2; -; Genomic_DNA.
DR   RefSeq; XP_001385518.2; XM_001385481.1.
DR   AlphaFoldDB; A3LXM3; -.
DR   SMR; A3LXM3; -.
DR   STRING; 4924.XP_001385518.2; -.
DR   EnsemblFungi; ABN67489; ABN67489; PICST_62098.
DR   GeneID; 4840054; -.
DR   KEGG; pic:PICST_62098; -.
DR   eggNOG; ENOG502QSQX; Eukaryota.
DR   HOGENOM; CLU_042310_0_0_1; -.
DR   InParanoid; A3LXM3; -.
DR   OMA; VEYKRHY; -.
DR   OrthoDB; 1313957at2759; -.
DR   Proteomes; UP000002258; Chromosome 6.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0048309; P:endoplasmic reticulum inheritance; IEA:InterPro.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   InterPro; IPR031398; She3.
DR   Pfam; PF17078; SHE3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; Membrane; mRNA transport;
KW   Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..442
FT                   /note="SWI5-dependent HO expression protein 3"
FT                   /id="PRO_0000408935"
FT   REGION          280..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          11..162
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        327..428
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   442 AA;  49999 MW;  0BF554D48F76DFEA CRC64;
     MEDNTASNKP TSRVIDSLHS QIDDLKTELE TVKISHDDYK KKYVLVSQKN DSFVDQLANA
     KHENDMINAL LKRKERRIAD LEDQYNELSS SNESLQLNNK NMKIRCENLQ QSSASSTAEY
     ERLKIAYDAL IASQVEYKRH YQKELNTLAS KLEAYKTENK QRFQDLSSKL SSNDKDIDTL
     LDSMTNKRKA LDNLYVNKNK TILELLTSLA KAAKIHGLDT KSTLEENTVA ISSLLEKYPD
     LQEKILTHEK VEVDLDELIS ESNETLSNCS FESEATLVNS PELSDSASQS KNADHLKQDV
     KASSLSRSNT LQAKKRKNKR NSVRIDSKSG PDFSSITTPT TGQFALPKKP TFTSNNDNRG
     FSSRSPSDSS RNITPPHQDY EINPKFQNQN VHLNNDTNNK GGNYNNNNNN RSKRKSLYGG
     QYNSKRNSQI IDPNALNISM TT