ID   SHE3_VANPO              Reviewed;         498 AA.
AC   A7TJJ7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=SWI5-dependent HO expression protein 3;
GN   Name=SHE3; ORFNames=Kpol_534p19;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: RNA-binding protein that binds specific mRNAs including the
CC       ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the
CC       mRNA localization machinery that restricts accumulation of certain
CC       proteins to the bud and in the daughter cell. Required for the delivery
CC       of cortical endoplasmic reticulum into the emerging bud (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE3 family. {ECO:0000305}.
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DR   EMBL; DS480402; EDO17540.1; -; Genomic_DNA.
DR   RefSeq; XP_001645398.1; XM_001645348.1.
DR   AlphaFoldDB; A7TJJ7; -.
DR   SMR; A7TJJ7; -.
DR   STRING; 436907.A7TJJ7; -.
DR   EnsemblFungi; EDO17540; EDO17540; Kpol_534p19.
DR   GeneID; 5545762; -.
DR   KEGG; vpo:Kpol_534p19; -.
DR   eggNOG; ENOG502QSQX; Eukaryota.
DR   HOGENOM; CLU_038734_0_0_1; -.
DR   InParanoid; A7TJJ7; -.
DR   OMA; HFMANIN; -.
DR   OrthoDB; 1540192at2759; -.
DR   PhylomeDB; A7TJJ7; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0048309; P:endoplasmic reticulum inheritance; IEA:InterPro.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   InterPro; IPR031398; She3.
DR   Pfam; PF17078; SHE3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; Membrane; mRNA transport;
KW   Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..498
FT                   /note="SWI5-dependent HO expression protein 3"
FT                   /id="PRO_0000408936"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          394..498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          86..272
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        27..82
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..409
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..481
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..498
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   498 AA;  55690 MW;  6820A568619D6C4A CRC64;
     MSLEDSRISN EDDSELLPPN KVVSSHGVFM ASMNGSPQKI MRPSSVSGGS VNGSVSGSSQ
     IGSGPNSNNN NNSSNNNNNS GSISSTKVIE ALHEQIDALT NTNLKLTVQS QGLLEKLENS
     QQREGKFMEN IASLRHENDN LSTMLNRKTR KLKDTELELE ELKEKFDKIT TEKKVLDDDL
     NKTSASETKL KEEMSMIENQ YNSLIDSHEY YKDKYLQEIN QLKRSLEDLT TEQENYLKRT
     NENNKLVEEK IDNYNNSFNQ LKEINESLNN IIITKCESAI QELDLPNWVN LYKESKILVI
     DYAQQMNLEI PNNFKELVRD RTLEILESRS TSMSSQSSSE NRQQFNNNNN NSHNQSSGNE
     EPLRMVKLRT VSPNSFNNSG SSLPSHIKRS SFYGGTKSLS SSNSGIPGTL PGVKRSGSLR
     KPSSRLPSTN TEPFSSPSSP SLNGTNKFGQ NQNQASNSNS NPSQHNNSNI QLPGSRVSSV
     SHNPMHRKKR NSMMFHGN