ID   SHE9_AJECN              Reviewed;         369 AA.
AC   A6QU86;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=SHE9; ORFNames=HCAG_00942;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; CH476655; EDN03078.1; -; Genomic_DNA.
DR   RefSeq; XP_001543896.1; XM_001543846.1.
DR   AlphaFoldDB; A6QU86; -.
DR   SMR; A6QU86; -.
DR   STRING; 339724.A6QU86; -.
DR   EnsemblFungi; EDN03078; EDN03078; HCAG_00942.
DR   GeneID; 5450632; -.
DR   KEGG; aje:HCAG_00942; -.
DR   VEuPathDB; FungiDB:HCAG_00942; -.
DR   HOGENOM; CLU_025632_2_2_1; -.
DR   OMA; VPAYATK; -.
DR   OrthoDB; 719853at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..369
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000351045"
FT   TOPO_DOM        ?..176
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..345
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        367..369
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   COILED          128..156
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   369 AA;  40727 MW;  63CE5A7EC34C4F2B CRC64;
     MPALSIPQTV FLCAEGREGS RRGEERFHAA KERWEGQSGG AERGGNAGYF HKKGFRDIEK
     LKQDILAQEQ RVRETRTCVQ EAKEAYSTAI NRRSASQREV NELLQRKHAW SPTDLERFTS
     LYRSDHANER AETDAQEALV VAEREAEEAA ALLSKSILSR YHEEQIWSDK IRRMSTWGTW
     GLMGVNVLLF LIFQVAVEPW RRRRLVKGFE EKVMEALERE NGMKEGVGAV EGATLRDGAT
     TVPAAAAAPS LIAEPVTPTF SNISDETPAG PSDAAMFTEQ DVPDPAVVSA TAPTLTALQP
     NKQSQSSTSA LLLPPDASLS PDSWRQTIHD LFGERRITLS QRELTTVALE SAAAGAAVMG
     VLIALFRPR