ID   SHE9_ASHGO              Reviewed;         447 AA.
AC   Q753C3;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Sensitive to high expression protein 9 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=SHE9; OrderedLocusNames=AFR393W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for the maintenance of the structure of the
CC       mitochondrial inner membrane. Involved in mitochondrial morphology.
CC       Causes growth arrest when highly overexpressed (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SHE9 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53764.1; -; Genomic_DNA.
DR   RefSeq; NP_985940.1; NM_211295.1.
DR   AlphaFoldDB; Q753C3; -.
DR   STRING; 33169.AAS53764; -.
DR   EnsemblFungi; AAS53764; AAS53764; AGOS_AFR393W.
DR   GeneID; 4622212; -.
DR   KEGG; ago:AGOS_AFR393W; -.
DR   eggNOG; ENOG502QQ1E; Eukaryota.
DR   HOGENOM; CLU_025632_5_1_1; -.
DR   InParanoid; Q753C3; -.
DR   OMA; DIWERIK; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR   InterPro; IPR008839; MDM33_fungi.
DR   PANTHER; PTHR31961; PTHR31961; 1.
DR   Pfam; PF05546; She9_MDM33; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..447
FT                   /note="Sensitive to high expression protein 9 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000351046"
FT   TOPO_DOM        ?..281
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..381
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        403..423
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        445..447
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   COILED          74..196
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   447 AA;  51476 MW;  53C25C664B2FCD79 CRC64;
     MPIYQLALPR SVLPRCRAVR YSRLLHSARC YSQDSQPKPG NTILQQLRKK LEPFCNSTKD
     KLEQTCAQVR YSSMQLRYHL EKARASVQEA NKKLVQQERE GENSMLTFND DLENKSKIVD
     LPSERERKRR QWSRKLEFYI DSLQETIFTA TKALNDVTGY SSIEKLRKSI DMMETQLQET
     KRKLMQLREA HSDAVAVRNQ SQRQVNELLQ RKHMWSPGDL ESFTRLYKED ADNVRRQEEA
     NASLKAMEAK EEELSNSLHR AILTRYHEEQ IWSDKIRRTS TWGTFILMGL NILLFLVVQL
     LLEPWKRRRL TNSFEDKVKR ALEDHSLQHN LVLDRLSDRI SEKIDAEMVH GIAPVPLPER
     TEQPEQPPAA TTSGQPLGLR EALASVGAAI AAEFGFFQAW IADHVRAIGG PTLSALQGFS
     GWPVLHIDLY NTVIFTCGML LGLLVSH